Corona Virus Disease 2019, a growing threat to children?

Yang, Pu; Pin, Liu; Li, Dan; Zhao, Dongchi

doi:10.1016/j.jinf.2020.02.024

Cited by 101 publications

(103 citation statements)

References 6 publications

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“…2 Alternatively, these data may reflect altered viral shedding (either in titre or duration) in children or an alternate, less efficient route of virus transmission from infected children to adults. 24,66 It is also possible that children simply have fewer interactions outside of the home than adults and are therefore less likely to be index cases. This may be magnified in countries which have implemented school closures in an attempt to control the outbreak.…”

Section: Discussionmentioning

confidence: 99%

“…There is a growing body of evidence suggesting that asymptomatic individuals play an important role in the transmission of SARS-CoV-2 in the community 68-70 ; However, such studies do not negate the results of the present study, as both children AND adults can present with an asymptomatic infection. This is perhaps best demonstrated by the outbreak of SARS-CoV-2 on board the Diamond Princess cruise ship 66 . Here, 634 individuals were infected.…”

Section: Discussionmentioning

confidence: 99%

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A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters

Zhu

Bloxham

Hulme

et al. 2020

Preprint

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BACKGROUND: Since its identification on the 7 th of January 2020, SARS-CoV-2 has spread to more than 180 countries worldwide, causing >11,000 deaths. At present, viral disease and transmission amongst children is incompletely understood. Specifically, there is concern that children could be an important source of SARS-CoV-2 in household transmission clusters. METHODS:We performed an observational study analysing literature published between December 2019 and March 2020 of the clinical features of SARS-CoV-2 in children and descriptions of household transmission clusters of SARS-CoV-2. In these studies the index case of each cluster defined as the individual in the household cluster who first developed symptoms.FINDINGS: Drawing on studies from China, Singapore, South Korea, Japan, and Iran a broad range of clinical symptoms were observed in children. These ranged from asymptomatic to severe disease. Of the 31 household transmission clusters that were identified, 9.7% (3/31) were identified as having a paediatric index case. This is in contrast other zoonotic infections (namely H5N1 influenza virus) where 54% (30/56) of transmission clusters identified children as the index case.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters

Zhu

Bloxham

Hulme

et al. 2020

Preprint

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“…Yang et al have noted that the child with hydronephrosis in question had bilateral hydronephrosis with renal calculus. 45 The percentage of 123 US children with COVID-19 in need of hospital admission was 1.6%-2.5% with no child needing intensive care. 51…”

Section: According To the Disease Severity Classification Used By Sevmentioning

confidence: 99%

“…52 In a smaller case series of 10 Chinese children diagnosed outside Wuhan, eight had fever and six had a cough. 7 In a study that has only been published in Chinese so far, but was referenced by Yang et al, 45 76.1% of 134 children with COVID-19 had fever.…”

Section: Symptomsmentioning

confidence: 99%

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

2020

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Aim:The coronavirus disease 2019 pandemic has affected hundreds of thousands of people. Data on symptoms and prognosis in children are rare. Methods:A systematic literature review was carried out to identify papers on COVID-19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using the MEDLINE and Embase databases between January 1 and March 18, 2020. Results:The search identified 45 relevant scientific papers and letters. The review showed that children have so far accounted for 1%-5% of diagnosed COVID-19 cases, they often have milder disease than adults and deaths have been extremely rare.Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia.Elevated inflammatory markers were less common in children, and lymphocytopenia seemed rare. Newborn infants have developed symptomatic COVID-19, but evidence of vertical intrauterine transmission was scarce. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances. Conclusions:The coronavirus disease 2019 has occurred in children, but they seemed to have a milder disease course and better prognosis than adults. Deaths were extremely rare.

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“…It is comforting that in six cases tested, breastmilk was negative for COVID-19 [8]; however, given the small number of cases, this evidence should be inferred with caution. The main risk for infants of breastfeeding is the close contact with the mother, who is likely to share infective airborne droplets and it is essential to protect and separate the infants immediately after birth for at least 14 days [34,35]. The risks and benefits of breastfeeding and any potential risks of transmission of the virus through breastmilk [17] should be discussed with her [17].…”

Section: Breastfeedingmentioning

confidence: 99%

Improving the quality of care in pregnancy and childbirth with coronavirus (COVID-19): a systematic review

Abdollahpour

Khadivzadeh

2020

The Journal of Maternal-Fetal & Neonatal Medicine

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In the context of serious coronavirus epidemic, it is critical that pregnant women not be ignored potentially life-saving interventions. So, this study was designed to improve the quality of care by health providers through what they need to know about coronavirus during pregnancy and childbirth. We conducted a systematic review of electronic databases was performed for published in English, before 25 March 2020. Finally, 29 papers which had covered the topic more appropriately were included in the study. The results of the systematic review of the existing literature are presented in the following nine sections: Symptoms of the COVID-19 in pregnancy, Pregnancy management, Delivery Management, Mode of delivery, Recommendations for health care provider in delivery, Neonatal outcomes, Neonatal care, Vertical Transmission, Breastfeeding. In conclusion, improving quality of care in maternal health, as well as educating, training, and supporting healthcare providers in infection management to be prioritized. Sharing data can help to countries that to prevent maternal and neonatal morbidity associated with the COVID-19.

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Corona Virus Disease 2019, a growing threat to children?

Cited by 101 publications

References 6 publications

A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters

A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

Improving the quality of care in pregnancy and childbirth with coronavirus (COVID-19): a systematic review

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