Corona discharge ion mobility spectrometry combined by homogenizer assisted dispersive liquid-phase microextraction; A rapid and sensitive method for quantification of nortriptyline

Zamani, Fatemeh; Farajmand, Bahman; Yaftian, Mohammad Reza

doi:10.1016/j.microc.2020.105540

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…Ion mobility spectrometry (IMS) as a powerful separation technique has gained wide acceptance for the detection of organic pollutants, such as drugs [23], explosives [24], and pesticides [25], based on their size and shape in a weak electric field. Furthermore, IMS can be employed for identifying isomeric compounds.…”

Section: Introductionmentioning

confidence: 99%

Preparation of magnetic molecularly imprinted polymer based on multiwalled carbon nanotubes for selective dispersive micro‐solid phase extraction of fenitrothion followed by ion mobility spectrometry analysis

Khojasteh

Bazmandegan‐Shamili

2022

J of Separation Science

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A novel molecularly imprinted polymer based on magnetic multiwalled carbon nanotubes was fabricated and applied for selective dispersive micro‐solid phase extraction of fenitrothion prior its determination by ion mobility spectrometry. The composite was synthesized using magnetic multiwalled carbon nanotubes as the support. Methacrylic acid was used as the functional monomer, fenitrothion as the template, ethylene glycol dimethacrylate as the cross‐linker, and 2,2‐azoisobutyronitrile as the initiator. The resultant polymer was characterized by FTIR spectroscopy, X‐ray diffraction, field emission scanning electron microscopy, Brunauer–Emmet–Teller analysis, thermogravimetric analysis, and vibrating sample magnetometer techniques. Experimental factors affecting the extraction efficiency such as pH and amount of sorbent were evaluated. Under optimum experimental conditions, the developed method displayed the linear range of 5–220 μg/L with a detection limit of 1.3 μg/L. The intra‐ and interday relative standard deviations for determination of fenitrothion were 3.6 and 4.7% (n = 6), respectively. Ultimately, the proposed method was used to monitor trace amounts of fenitrothion in fruits, vegetables, and water samples.

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Section: Introductionmentioning

confidence: 99%

Preparation of magnetic molecularly imprinted polymer based on multiwalled carbon nanotubes for selective dispersive micro‐solid phase extraction of fenitrothion followed by ion mobility spectrometry analysis

Khojasteh

Bazmandegan‐Shamili

2022

J of Separation Science

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“…Desorption electrospray ionization (DESI) was coupled to an ambient pressure drift time ion mobility time-of-flight mass spectrometer (DTIMS-TOFMS) for the direct analysis of active ingredients of pharmaceutical samples, including antidepressant drugs in tablets [ 10 ]. Corona discharge ionization (CD) was coupled to ion mobility for the determination of antidepressant drugs in urine [ 11 ], plasma [ 12 ], breast milk, and river water samples [ 13 ]. Piendl et al [ 14 ] reported an online hyphenation of chip-based high-performance liquid chromatography (chip-HPLC) with ion mobility spectrometry (MS) to separate isobaric antidepressants.…”

Section: Introductionmentioning

confidence: 99%

Effects of the LC mobile phase in vacuum differential mobility spectrometry-mass spectrometry for the selective analysis of antidepressant drugs in human plasma

et al. 2022

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The effect of LC mobile phase composition and flow rate (2–50 µL/min) on mobility behavior in vacuum differential mobility spectrometry (vDMS) was investigated for electrosprayed isobaric antidepressant drugs (AD); amitriptyline, maprotiline, venlafaxine; and structurally related antidepressants nortriptyline, imipramine, and desipramine. While at 2 µL/min, no difference in compensation voltage was observed with methanol and acetonitrile, at 50 µL/min, acetonitrile used for LC elution of analytes enabled the selectivity of the mobility separation to be improved. An accurate and sensitive method could be developed for the quantification of six AD drugs in human plasma using trap/elute micro-LC setup hyphenated to vDMS with mass spectrometric detection in the selected ion monitoring mode. The assay was found to be linear over three orders of magnitude, and the limit of quantification was of 25 ng/mL for all analytes. The LC-vDMS-SIM/MS method was compared to a LC-MRM/MS method, and in both cases, inter-assay precisions were lower than 12.5 and accuracies were in the range 91.5–110%, but with a four times reduced analysis time (2 min) for the LC-vDMS-SIM/MS method. This work illustrates that with vDMS, the LC mobile phase composition can be used to tune the ion mobility separation and to improve assay selectivity without additional hardware. Graphical abstract

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Electrochemically controlled solid-phase microextraction based on conductive molecularly imprinted polymer combined with ion mobility spectrometry for separation and determination of thiopental

2022

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Corona discharge ion mobility spectrometry combined by homogenizer assisted dispersive liquid-phase microextraction; A rapid and sensitive method for quantification of nortriptyline

Cited by 8 publications

References 29 publications

Preparation of magnetic molecularly imprinted polymer based on multiwalled carbon nanotubes for selective dispersive micro‐solid phase extraction of fenitrothion followed by ion mobility spectrometry analysis

Preparation of magnetic molecularly imprinted polymer based on multiwalled carbon nanotubes for selective dispersive micro‐solid phase extraction of fenitrothion followed by ion mobility spectrometry analysis

Effects of the LC mobile phase in vacuum differential mobility spectrometry-mass spectrometry for the selective analysis of antidepressant drugs in human plasma

Electrochemically controlled solid-phase microextraction based on conductive molecularly imprinted polymer combined with ion mobility spectrometry for separation and determination of thiopental

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