Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry

Dinda, Biswanath; Kyriakopoulos, Anthony M.; Dinda, Subhajit; Zoumpourlis, Vassilis; Thomaidis, Nikolaos S.; Velegraki, Aristea; Markopoulos, Charlambos; Dinda, Manikarna

doi:10.1016/j.jep.2016.09.042

Cited by 132 publications

(121 citation statements)

References 146 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…a Modified according to Dinda et al (2016) and Hosseinpour-Jaghdani et al (2017) .b Modified according to Huang et al (2018) .…”

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

“…The reported anti-amnestic and neuroprotective activities of both species seem to be based on similar constituents such as flavonoids and terpenoids which express antioxidant or more precisely radical scavenging effects (Dinda et al, 2016; Cooper and Ma, 2017; Huang et al, 2018). Animal experiments as well as biochemical investigations showed that the dried fruit powder and fruit extracts were able to increase level of physiological antioxidants such as glutathione and antioxidative enzymes, including superoxide dismutase or catalase, as well as to prevent cells and tissues against free radicals in this manner (Lee et al, 2006; Kim et al, 2011; Celep et al, 2012; Lee N. H. et al, 2012; Sozanski et al, 2014).…”

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

“…Discussing these effects with respect to the ethnopharmacological reports regarding the traditional use of both species in the past some evidence for beneficial effects on heart and circulation system may exist. This concerns especially the traditional use of C. mas to treat disorders or complaints related to aging processes like diabetes, ischemia or cardiovascular diseases (Dinda et al, 2016; Hosseinpour-Jaghdani et al, 2017). Due to the use of C. officinalis in TCM as a component of complex drug mixtures (Chen et al, 2008; Liu et al, 2013; Dai et al, 2016), a clear assignment to effects on heart and circulation system is rather difficult.…”

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

“…Only a clear selectivity in cytotoxicity between tumor and non-tumor cells corresponding with appropriate animal in vivo experiments opens up the possibility for the statement of antitumor activity. The reported antioxidant activity for both species (Dinda et al, 2016; Hosseinpour-Jaghdani et al, 2017; Huang et al, 2018) might be a hint for protective effects against tumor-inducing free radicals but for both species only in vitro models have been used to demonstrate such effects (Chang et al, 2004; Chu et al, 2009; Turker et al, 2012; Yousefi et al, 2015). In particular, the flavonoids are regarded as safe and easily obtainable.…”

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

See 3 more Smart Citations

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

View full text Add to dashboard Cite

Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times. Cornus mas (cornelian cherry) is native to southern Europe and southwest Asia, whereas C. officinalis (Asiatic dogwood, cornel dogwood) is a deciduous tree distributed in eastern Asia, mainly in China, as well as Korea and Japan. Based on the different geographic distribution of the closely related species but clearly distinct taxa, the ethnopharmacological use of C. mas and C. officinalis seems to be independently originated. Many reports on the quality of C. mas fruits were performed due to their value as edible fruits, and few reports compared their physicochemical properties with other edible fruits. However, the detailed phytochemical profiles of C. mas and C. officinalis, in particular fruits, have never been compared. The aim of this review was highlighting the similarities and differences of phytochemicals found in fruits of C. mas and C. officinalis in relation to their biological effects as well as compare the therapeutic use of fruits from both traditional species. The fruits of C. mas and C. officinalis are characterized by the presence of secondary metabolites, in particular iridoids, anthocyanins, phenolic acids and flavonoids. However, much more not widely known iridoids, such as morroniside, as well as tannins were detected particularly in fruits of C. officinalis. The referred studies of biological activity of both species indicate their antidiabetic and hepatoprotective properties. Based on the available reports antihyperlipidemic and anticoagulant activity seems to be unique for extracts of C. mas fruits, whereas antiosteoporotic and immunomodulatory activities were assigned to preparations of C. officinalis fruits. In conclusion, the comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood. Thus, these phytochemicals are considered the important factor determining the biological activity and justifying the use of C. mas and C. officinalis in the traditional European and Asiatic medicine.

show abstract

“…a Modified according to Dinda et al (2016) and Hosseinpour-Jaghdani et al (2017) .b Modified according to Huang et al (2018) .…”

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

See 2 more Smart Citations

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Recent studies showed that it has different health beneficial effects such as antioxidant activity, anti‐inflammatory effect, cardioprotective, and lipid‐lowering properties. These health effects were recently reviewed in different articles (Dinda et al, ; Hosseinpour‐Jaghdani, Shomali, Gholipour‐Shahraki, Rahimi‐Madiseh, & Rafieian‐Kopaei, ).…”

Section: Introductionmentioning

confidence: 99%

Convective and refractance window drying of cornelian cherry pulp: Effect on physicochemical properties

Tontul

Eroğlu

Topuz

2018

J Food Process Engineering

View full text Add to dashboard Cite

Cornelian cherry is a wild fruit contains considerable amounts of bioactive compounds such as ascorbic acid, anthocyanins, and phenolics. It has many different health beneficial effects due to these bioactive compounds. In the present study, convective drying and refractance window drying was employed in cornelian cherry pulp drying under different drying conditions. Moisture content (8.03–8.27 g/100 g), water activity (0.350–0.354), color properties, total monomeric anthocyanin content (247.47–347.3 mg C3G/kg dm), ascorbic acid content (0.81–0.90 g/kg dm), radical scavenging activity (0.87–1.47 g TEAA/kg dm), and 5‐hydroxymethylfurfural (18.80–24.10 mg/l) content of the powders were determined. According to the results, physicochemical properties of the samples produced by refractance window drying were better than those of convective drying. Higher drying temperatures and air velocities provided higher content of total monomeric anthocyanin content and radical scavenging activity in hot air drying. However, drying temperature was found to be ineffective on all tested parameters in refractance window dried samples. Overall, refractance window drying of cornelian cherry pulp at 90 °C is recommended to achieve good physicochemical properties. Practical applications Refractance window drying is an innovative drying system usually used in the drying of liquid and semi‐liquid foods. The results have shown that refractance window drying provided better physicochemical properties than convective drying in very short drying time.

show abstract

The effect of lyophilized dried cornelian cherry (Cornus mas L.) intake on anthropometric and biochemical parameters in women with insulin resistance: A randomized controlled trial

Celık,

Sargin,

Tamer

et al. 2023

Food Science & Nutrition

View full text Add to dashboard Cite

The aim of this study was to determine the effect on the anthropometric and biochemical parameters for women with insulin resistance when lyophilized dried cornelian cherry (Cornus mas L., CM) was added to medical nutrition therapy (MNT). The study was conducted with 84 women aged 18–45, who had been diagnosed with insulin resistance. Participants were randomized into four groups: MNT + 20 g lyophilized dried CM group (DCm, n = 22), MNT group (D, n = 21), only 20 g lyophilized dried CM group (Cm, n = 21), and the control group (C, n = 20). All participants were followed for 12 weeks. While pre‐ and post‐intervention biochemical parameters were recorded from patient files, anthropometric measurements and food consumption records were taken every 15 days. Pre‐intervention groups were homogeneously distributed. Post‐intervention, among the groups, all anthropometric measurements were similar between the DCm and D, while the percentage of decrease in insulin resistance‐related parameters was approximately two times greater in DCm than in D (p < .05). When the Cm and C were compared, it was found that all post‐intervention anthropometric measurements were similar, but the percentage of decrease in fasting blood glucose, fasting insulin, and HOMA‐IR (Homeostasis Model Assessment‐Insulin Resistance) values were greater in C (p < .05). In this study, it was concluded that CM consumption resulted with a decrease in insulin resistance‐related biochemical parameters independent of body weight change. Nevertheless, MNT has positive effects on women with insulin resistance, and adding lyophilized dried CM to MNT improves insulin resistance‐related parameters and may be beneficial for preventing the development of diabetes.

show abstract

Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry

Cited by 132 publications

References 146 publications

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Convective and refractance window drying of cornelian cherry pulp: Effect on physicochemical properties

The effect of lyophilized dried cornelian cherry (Cornus mas L.) intake on anthropometric and biochemical parameters in women with insulin resistance: A randomized controlled trial

Contact Info

Product

Resources

About