Abstract:The outermost layer of the skin is formed by the cornified envelope (CE), which is the end product of the process of keratinisation. This forms a barrier that is essential to protect the internal homeostasis of the organism from the external environment. The process of keratinisation proceeds according to a complex and elaborately controlled differentiation programme with the coordinated expression of genes encoding specialised components, enzymes and regulatory molecules. The CE is a specialised structure tha… Show more
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