Cornelian cherry fruit improves glycaemia and manifestations of diabetes in obese Zucker diabetic fatty rats

Capcarová, Marcela; Kalafová, Anna; Schwarzová, Marianna; Schneidgenová, Monika; Švík, Karol; Prnová, Marta Šoltésová; Slovák, Lukáš; Kováčik, Anton; Lóry, Viktória; Zórad, Štefan; Brindza, Ján

doi:10.1016/j.rvsc.2019.08.024

Cited by 19 publications

(14 citation statements)

References 27 publications

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“…A previous study [ 27 ] demonstrated that administration of Cornus mas at the same doses which were used in our research caused significant reduction of water intake in ZDF rats versus the diabetic control ones. However, feed intake in diabetic control group did not differ significantly when compared to both treated groups.…”

Section: Discussionsupporting

confidence: 50%

“…We determined insignificantly lower blood glucose level in both treated groups versus the C group. Capcarova et al [ 27 ] also observed that the rats from the E1 and E2 groups exhibit similar values of insulin than those from the diabetic control group. Therefore, other biochemical parameters that would reflect lipid-lowering properties of Cornelian cherry in diabetes were evaluated in our study.…”

Section: Discussionmentioning

confidence: 95%

“…The rats were housed in pairs, in cages of 1500 U Eurostandard Type IV S (Tecniplast, Buguggiate, Italy), with 12 h light/12 h dark cycle, at a room temperature of 22 ± 2 °C, with free access to food and drinking water. The complete rat feed mixture KKZ-P/M (register number 6147, Dobra Voda, Slovakia; composition of the mixture is given in the study by Capcarova et al [ 27 ]) was used for feeding. The animals were divided into 4 groups: L group (n = 7) consisted of non-diabetic lean rats and served as a negative control; C group (n = 7) included diabetic obese rats which were considered as a positive control; and E1 (n = 7) and E2 (n = 7) groups consisted of diabetic obese rats receiving 500 and 1000 mg/kg body weight (bw) of Cornelian cherry pulp, respectively, for 10 weeks.…”

Section: Methodsmentioning

confidence: 99%

“…Groups E1 and E2 received the exact dose of Cornus mas directly into the stomach, every day, using sterile oral rodent gavage (Instech, Plymouth, MA, USA), whereas groups L and C received distilled water by the same way. The doses of Cornus mas were selected based on the study by Capcarova et al [ 27 ]. The animals were sacrificed by intraperitoneal injection of xylazine/zoletil cocktail and all samples were collected after deep anesthesia.…”

Section: Methodsmentioning

confidence: 99%

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Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Omelka

Blahová

Kováčová

et al. 2020

Animals

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Cornelian cherry (Cornus mas L.) is a medicinal plant with a range of biological features. It is often used as a nutritional supplement in the treatment of diabetes mellitus. Our study was aimed to first investigate the effects of Cornelian cherry pulp on bone quality parameters in Zucker diabetic fatty (ZDF) rats. Moreover, lipid-lowering properties of this fruit were also evaluated. Adult rats (n = 28) were assigned into four groups of seven individuals each: L group (non-diabetic lean rats), C group (diabetic obese rats), and E1 and E2 groups (diabetic obese rats receiving 500 and 1000 mg/kg body weight of Cornelian cherry pulp, respectively, for 10 weeks). Significantly lower levels of triglyceride, total cholesterol and alkaline phosphatase activity were determined in the E2 group versus the C group. A higher dose of Cornus mas also had a beneficial impact on femoral weight, cortical bone thickness, relative volume of trabecular bone and trabecular thickness. We observed elevated density of Haversian systems and accelerated periosteal bone apposition in both treated groups (E1 and E2). Our results clearly demonstrate that Cornelian cherry pulp has a favorable effect on lipid disorder and impaired bone quality consistent with type 2 diabetes mellitus in a suitable animal model.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Omelka

Blahová

Kováčová

et al. 2020

Animals

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“…We suppose that a higher number of ZDF rats in each group and/ or elevated concentrations of both substances used could lead to statistically significant differences. According to Capcarova et al (2019), Capcarova et al (2020, ZDF rats treated with a higher doses of bee bread and Cornus mas (700 mg/kg b.w. and 1 000 mg/kg b.w., respectively, for 10 weeks) had significantly lower blood glucose concentrations in comparison with the diabetic control group.…”

Section: Discussionmentioning

confidence: 99%

Effects of bee bread, Cornelian cherries treatment on the femoral bone structure using Zucker diabetic fatty rats as an animal model

Martiniaková¹,

Blahová²,

Kováčová³

et al. 2021

Vet. Med. - Czech

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: This is a pilot study dealing with the reduced femoral bone structure in Zucker diabetic fatty (ZDF) rats following a 10 week treatment with bee bread and Cornelian cherries. The adult ZDF rats were divided into 4 groups: the E1 group received bee bread (500 mg/kg b.w. daily), the E2 group received Cornelian cherries (500 mg/kg b.w. per day), the E3 group was simultaneously supplemented by bee bread and Cornelian cherries (500 + 500 mg/kg b.w. daily), and the C group served as an untreated diabetic control. A non-significant decrease in the blood glucose, total cholesterol, triglyceride concentrations, ALP activity and a non-significant increase in the insulin, total body weight of the ZDF rats, femoral length and weight were observed in the E1, E2, and E3 groups. The treatments had no impact on the relative volume of the cortical bone, bone mineral density, bone surface and cortical bone thickness. On the contrary, the relative volume of the trabecular bone, trabecular thickness and trabecular bone surface were significantly increased in the E1 group. The relative volume of the trabecular bone and trabecular thickness were significantly elevated in the E2 group. In the E3 group, the trabecular thickness was found to have significantly increased. Single administrations of either bee bread or Cornelian cherries had more positive effects on the trabecular bone microarchitecture in the ZDF rats than the simultaneous supplementation.

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Therapeutic Potential of Cornus Genus: Navigating Phytochemistry, Pharmacology, Clinical Studies, and Advanced Delivery Approaches

Badoni,

Rawat,

Mahato

et al. 2024

Chemistry & Biodiversity

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The genus Cornus (Cornaceae) plants are widely distributed in Europe, southwest Asia, North America, and the mountains of Central America, South America, and East Africa. Cornus plants exhibit antimicrobial, antioxidative, antiproliferative, cytotoxic, antidiabetic, anti‐inflammatory, neuroprotective and immunomodulatory activities. These plants are exploited to possess various phytoconstituents such as triterpenoids, iridoids, anthocyanins, tannins and flavonoids. Pharmacological research and clinical investigations on various Cornus species have advanced significantly in recent years. Over the past few decades, a significant amount of focus has also been made into developing new delivery systems for Cornus mas and Cornus officinalis. This review focuses on the morphological traits, ethnopharmacology, phytochemistry, pharmacological activities and clinical studies on extracts and active constituents from plants of Cornus genus. The review also highlights recent novel delivery systems for Cornus mas and Cornus officinalis extracts to promote sustained and targeted delivery in diverse disorders. The overwhelming body of research supports the idea that plants from the genus Cornus have therapeutic potential and can be investigated in the future for treatingseveral ailments.

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Cornelian cherry fruit improves glycaemia and manifestations of diabetes in obese Zucker diabetic fatty rats

Cited by 19 publications

References 27 publications

Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

Effects of bee bread, Cornelian cherries treatment on the femoral bone structure using Zucker diabetic fatty rats as an animal model

Therapeutic Potential of Cornus Genus: Navigating Phytochemistry, Pharmacology, Clinical Studies, and Advanced Delivery Approaches

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