Corneal ulcers in corneal transplants

Abstract

Twenty-nine eyes, representing an infection rate of 4.9%, developed corneal ulcers following corneal transplant surgery; 26 with available data are presented. All occurred in the graft or at the wound margin. The median postoperative time to ulcer development was 5.5 months. All eyes were on topical steroids when the ulcer developed. Other associated factors were: loose sutures, bandage lenses and eyes grafted for herpes simplex keratitis. Ninety percent of the ulcers had one or more of these factors. Positive cultures for organisms were obtained in 75% and positive gram stain in 68% of the ulcers. Nine genera of bacteria were cultured; S. epidermidis, S. pneumoniae, P. aeruginosa and Corynebacterium were the most common organisms. Ninety-five percent of the bacteria tested were sensitive to gentamicin. Visual reduction occurred in 46% of the cases overall; herpetic corneas had an 88% incidence of visual loss.

Persistent epithelial defects and ulcers in repeated corneal transplantation: incidence, causative agents, predisposing factors and treatment outcomes

“…In our series, 9% of the regrafts developed ulcers. This was within the range of 1.76-11.9% reported for primary corneal transplantation [5][6][7][8][9][10]. Thus, the overall incidence of persistent epithelial defects and ulcers in our series of repeated grafts did not exceed the incidence of other studies pertaining to primary keratoplasty, although it would be expected that in regrafts it would be higher.…”

“…In contrast to epithelial defects, corneal graft ulcers have been studied after primary corneal transplantation, but not in repeated transplantation [5][6][7][8][9][10][11][12]. Repeated corneal grafts represent a group with high risk for failure compared with primary grafts.…”

Microbial keratitis after penetrating keratoplasty

“…Case-notes of patients under the care of the [1][2][3][4][5][6][7][8][9][10]. There were eight such cases.…”

Bilateral simultaneous Achromobacter xylosoxidans keratitis following penetrating keratoplasty

“…[13][14][15][16] Predisposing factors include loose sutures, epithelial defects, bandage contact lens wear, topical steroid use, and ocular surface and adnexal abnormalities. 17 Different pathogens have been implicated as causative agents of infectious keratitis following PKP.…”