Corneal Ulcer due to Monkeypox Infection

Lamas-Francis, David; Treviño, Mercedes; Pérez-Freixo, Hugo; Martínez-Pérez, Laura; Touriño, Rosario; Rodríguez-Ares, Teresa

doi:10.1080/09273948.2022.2153343

Cited by 9 publications

(9 citation statements)

References 7 publications

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“…During the 2022 mpox outbreak, corneal infection seems rare occurring in 2 of 588 patients with mpox (0.3%) at our infectious disease unit between May and October and in 4 of 26577 mpox cases in the US . Only 4 cases have been reported in the literature:1 geographic ulcer, 1 serpiginous linear centripetal keratitis, and 2 undescribed cases . Our cases suggest that arcuate serpiginous centripetal epithelial keratitis, as described by Finamor et al, is specific to mpox.…”

Section: Discussionsupporting

confidence: 49%

Severe Corneal Involvement Associated With Mpox Infection

et al. 2023

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Section: Discussionsupporting

confidence: 49%

Severe Corneal Involvement Associated With Mpox Infection

et al. 2023

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“…9 Another article mentioned a pediatric patient with positive PCR for cutaneous mpox with severe conjunctivitis, corneal opacities, and erythematous sclera. 10 We also found a report of a patient with a corneal ulcer due to mpox infection with limbitis, 11 which is believed to have occurred due to the patient's autoinoculation from the skin infestation. A disciform keratitis was related to mpox in a 36-year-old man, with keratic precipitates (KP) and epithelial defect (ED).…”

Section: Discussionmentioning

confidence: 90%

Persistent and Severe Mpox Keratitis Despite Systemic and Topical Treatment

Domínguez García,

Gutierrez-Arroyo,

Miguel-Buckley

et al. 2024

Cornea

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Purpose: The purpose of this study was to report a case of peripheral ulcerative keratitis in a patient diagnosed with corneal polymerase chain reaction (PCR) and a positive mpox culture. Methods: This is a case report. Results: An immunocompetent 54-year-old man was diagnosed with conjunctivitis in his left eye 15 days after being diagnosed with mucocutaneous monkeypox. He received treatment with dexamethasone 0.1% and tobramycin 0.3% eye drops for 2 weeks. Two weeks after discontinuing this treatment, he developed peripheral ulcerative keratitis and a paracentral epithelial defect. Mpox keratitis was diagnosed by corneal culture and PCR. Corneal inflammation persisted for more than 6 months, manifested as corneal epithelial defect, limbitis, endotheliitis, neurotrophic changes, and trabeculitis. This persistence was observed alongside positive corneal PCR results, despite undergoing 2 courses of trifluorothymidine, 2 courses of oral tecovirimat, and intravenous cidofovir. An amniotic membrane transplantation was then performed. Conclusions: Persistent corneal pain and replication are possible with the mpox virus, even in immunocompetent patients. Having received treatment with topical corticosteroids before antiviral treatment for the pox virus may have contributed to the severity and persistence of the clinical condition. Cycle threshold PCR values can be used to support the diagnosis and monitor treatment effectiveness.

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“…The first genital lesion appeared 24 days before. Lamas-Francis (2022) [ 43 ] Spain Case report 1 45 y, male rtPCR Keratitis with epithelial corneal ulcer, superior limbitis and anterior chamber 0.5+ cells. Unilateral No.…”

Section: Resultsmentioning

confidence: 99%

“…Four case reports described anterior uveitis [ 34 , 36 , 42 , 43 ]. All had mild inflammation (0.5 or 1+ of cells) and were accompanied by corneal compromise.…”

Section: Resultsmentioning

confidence: 99%