Corneal transplantation in aniridia‐related keratopathy with a two‐year follow‐up period, an uncommon disease with precarious course

Viberg, Andreas; Vicente, André; Samolov, Branka; Hjortdal, Jesper; Byström, Berit

doi:10.1111/aos.15229

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…For example, A. Viberg et al performed corneal limbal stem cell transplantation, L. C. Van der Wekken-Pas et al also conducted a study on the treatment of Candida keratitis and endophthalmitis after corneal transplantation, and S. Obata et al performed antivascular endothelial growth factor therapy and laser therapy for Retinopathy of Prematurity. However, physical assistance as well as pharmacologic surgical treatment can only slow down the progression of ocular lesions and do not accomplish complete repair of the visual senses [1][2][3]. Visual Prosthesis is an implantable medical electronic device that is currently the most promising technical means to assist patients with visual impairment or severe blindness in restoring visual function [4].…”

Section: Introductionmentioning

confidence: 99%

Improved VGG Algorithm for Visual Prosthesis Image Recognition

Li,

Jahng

et al. 2024

IEEE Access

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With the development of bio-informatics, visual prostheses have become an effective method for blind people to restore visual function. To meet the visual needs of visual implant recipients, this study explored the problem of in vitro image processor image recognition and classification. It selected the convolutional neural network framework VGG as the technical core, introduced the fruit fly optimization algorithm for optimizing the VGG recognition model, and constructed a visual prosthesis image recognition model on the ground of improved VGG. The experiment demonstrated that the improved fruit fly search algorithm had an average absolute error and root mean square error values lower than 0.4, which was superior to other intelligent optimization algorithms. The performance of the improved image recognition model has been significantly improved, with a maximum AUC value of 0.942, a recognition accuracy range of 68.29%-97.23%, and a stable fitness curve of around 97.00. The maximum F1 value of the image recognition model designed in the study reached 91.47%, and the loss function curve converged to the minimum value. In the application of visual prostheses, the recognition accuracy and R-squared performance of this model were both the best. Compared with natural human vision, the contrast and functional visual effects matched well, the processing speed was faster, and the delay time did not affect the actual application of visual prostheses, achieving high user satisfaction. This study can enrich and improve the theoretical foundation of visual image analysis and visual prosthetics, and help visually impaired groups improve their lives and quality of life.

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Section: Introductionmentioning

confidence: 99%

Improved VGG Algorithm for Visual Prosthesis Image Recognition

Li,

Jahng

et al. 2024

IEEE Access

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“…In some cases, pannectomy with amniotic membrane transplantation as a patch or penetrating keratoplasty is performed or penetrating keratoplasty in a combination with limbal stem cell transplantation. 4,5 The study of Viberg et al 6 showed recurring visual impairment in approximately 60% of patients with AAK 2 years after surgery. Patients can develop AAK at a young age.…”

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confidence: 99%

Secondary Data Analysis of Inflammation-Related mRNAs in Conjunctival Impression Cytology Samples of Aniridia Patients

Stachon,

Latta,

Fries

et al. 2023

Cornea

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Purpose: Aniridia is a rare corneal disease that is often associated with aniridia-associated keratopathy (AAK). In AAK, the conjunctival tissue crosses the limbal border, forming a corneal pannus that extends into the corneal center. With increasing AAK severity, corneal pannus formation, vascularization, and ocular surface inflammation increase. The purpose of this study was to investigate inflammation-related mRNA expression in conjunctival epithelial cells in AAK and its relationship with AAK severity. Methods: Using impression cytology, bulbar conjunctival cells were sampled from 20 subjects with congenital aniridia and 20 age-matched and sex-matched healthy control subjects. RNA was extracted, and mRNA analyses were performed using microarray, which was evaluated for inflammatory markers. Results: In the analyzed aniridia subjects, 70 deregulated mRNAs encoding proinflammatory or antiinflammatory cytokines or factors associated with chronic inflammation, including increased IL-1, IL-8, and MIP3A/CCL20 mRNA. The most downregulated mRNA was TIMP3, and the most upregulated mRNA was Protein c-Fos. Of the 70 mRNAs, 14 inflammation-related genes were altered only in the mild AAK forms, whereas only 2 mRNAs were altered only in the severe AAK forms (TLR4 and PPARG). Conclusions: The expression of numerous proinflammatory and antiinflammatory cytokines is deregulated at the ocular surface of aniridia subjects with mild AAK. Thus, early antiinflammatory treatment may prevent or slow down corneal scarring and pannus formation in aniridia subjects.

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