Corneal Staining and Subjective Symptoms With Multipurpose Solutions as a Function of Time

Abstract

This study design is a promising tool that can discriminate between the performance of different soft lens and multipurpose solution combinations rapidly using small patient samples. With some lens-care product combinations, corneal appearance may vary according to the time of day the patient is examined.

Corneal staining

“…40,41,44 By contrast, a true toxicity reaction is typically pathological and symptomatic and may require several days to resolve. 45 The dichotomy between PATH and true corneal staining is highlighted by several observational differences.…”

“…Although the clinical presentation is dramatic, this condition is benign, asymptomatic 41,42 and transient. 41 PATH is generally even but may be more prominent in the mid-peripheral cornea, coinciding with the slightly greater bearing of the soft lens against the cornea in those regions.…”

“…In addition to short duration and absence of symptomatology (e.g. discomfort), 41,42,46 differences include pattern and depth of fluorescence, 40,42,47 lack of concomitant signs (e.g. limbal or bulbar hyperaemia and corneal infiltrates), 41,48 and lack of association with future complications.…”

“…This condition is characterized by an increase in asymptomatic, superficial, punctate corneal hyperfluorescence associated with the use of multipurpose contact lens solutions ( Figure 16.12). [40][41][42] the degree of ocular discomfort. For example, an exposure keratitis in the form of an extensive inferior arcuate diffuse staining pattern can be virtually asymptomatic, whereas a small tracking stain caused by a foreign body trapped beneath a rigid lens can be excruciatingly painful.…”

“…(Courtesy of BioScience Communications. )Fluorescein Preservative approximately 30 minutes for PQ-1/Aldox) coincides with peak transient hyperfluorescence observed clinically in subjects wearing lenses that had been soaked in PHMBbased multipurpose solution (between 1 and 4 hours) and in PQ-1/Aldox-based multipurpose solution (around 30 minutes) 41,53. …”