Corneal sensitivity in health and disease

Lawrenson, John G

doi:10.1016/s0275-5408(96)00078-6

Cited by 22 publications

(14 citation statements)

References 17 publications

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“…The following myopic irregular astigmatism causes a drop in visual acuity; glasses can correct it in early cases, but PK and DALK are much more indicated in advanced disease. Keratoplasty cuts corneal nerves, so corneal sensitivity is off in the postoperative period, but improves with nerve growth [2,3,4]. In the current literature, we can find different data about corneal sensitivity after PK [5,6,7], while we cannot find any about DALK.…”

Section: Introductioncontrasting

confidence: 39%

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Corneal Sensitivity in Keratoconus after Penetrating and Deep Anterior Lamellar Keratoplasty

et al. 2010

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Purpose: To evaluate recovery of corneal sensitivity in the graft following penetrating keratoplasty (PK) or deep anterior lamellar keratoplasty (DALK) in patients with keratoconus. Materials and Methods: 113 eyes of 113 patients (39 females, 74 males) were examined. All eyes had undergone corneal grafting: 39 PK, 74 DALK. Corneal sensitivity tested using the Cochet-Bonnet esthesiometer was evaluated the day before and 3 days, 3, 6, 12 and 24 months after surgery. The corneal sensitivity recovery was associated with surgical techniques (PK or DALK), age and sex of recipient and donor, cadaver time and type of preservation of the cornea. Results: The average percentage of recovery of corneal sensitivity was 91% at 2 years. Surgical techniques and other qualitative and quantitative variables did not affect the statistically significant recovery of corneal sensitivity. Conclusions: In both surgical techniques, PK and DALK, we noticed a good recovery of corneal sensitivity in 2 years.

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Section: Introductioncontrasting

confidence: 39%

“…Corneal sensitivity changes with both ocular and general pathologies and physiological variations [3]. When the corneal sensitivity is within the physiological limits, it is a sign of normal endothelial function [17].…”

Section: Discussionmentioning

confidence: 99%

Corneal Sensitivity in Keratoconus after Penetrating and Deep Anterior Lamellar Keratoplasty

et al. 2010

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“…Reduced corneal sensitivity is part of the generalized sensory neuropathy found in diabetes mellitus 20. Ruben21 found significantly reduced corneal sensitivity in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have shown increased corneal thickness in diabetic patients7–9 and persistent corneal edema after cataract extraction and vitrectomy, not attributable to epithelial defects, suggesting abnormal function of the corneal endothelium 10,11. Diabetic patients have also been found to have reduced corneal sensitivity as part of generalized sensory neuropathy 12. In spite of the unspecific character of the damage and the subjectivity of the measurement, corneal sensitivity is an interesting parameter to take into consideration among diabetic patients 13…”

Section: Introductionmentioning

confidence: 99%

The anterior segment of the eye in diabetes

Adeoti¹,

Isawumi²,

Ashaye³

et al. 2012

OPTH

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PurposeA prospective study to examine the anterior segment of the eye in patients with diabetes mellitus.Materials and methodsThe anterior segments of the eyes of 181 patients with diabetes mellitus were examined. The commonest finding in the lids was warts, followed by poliosis and chalazia, and, in the conjunctiva, tortuous conjunctival vessels inferiorly (36.50%), pterygium (14.92%), and pingueculum (14.37%). Corneal sensitivity was reduced in 25 (13.80%) patients. Iris atrophy was the commonest finding in the iris. Dilatation of the pupil was delayed in 34 (18.79%) patients. Cataract was found in 119 (65.75%) patients. Forty-one (22.65%) patients had intraocular pressure greater than 21 mmHg. Seven (3.87%) patients, four (2.21%) patients, and one (0.55%) patient had seventh, third, and fourth palsy, respectively. No patient had sixth nerve palsy.ConclusionPrimary care physicians and other allied health care professionals who are first in contact with patients are enjoined to familiarize themselves with the anterior segment features of diabetes mellitus and take necessary action when they are detected.

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“…11,30-33 In the present study we investigated the effects of CLD on corneal sensitivity to cooling pneumatic stimuli in contact lens wearers and we showed differences in sensory function between groups (Figure 1). Consistent with previous results, 11,12 sensitivity in the asymptomatic group tended to be reduced compared to controls suggesting neural adaptation.…”

Section: Discussionmentioning

confidence: 75%

Hypersensitivity to Cold Stimuli in Symptomatic Contact Lens Wearers

Situ

Simpson²,

Begley³

2016

Optom Vis Sci

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Purpose To examine the cooling thresholds and the estimated sensation magnitude at stimulus detection in controls and symptomatic and asymptomatic contact lens (CL) wearers, in order to determine whether detection thresholds depend on the presence of symptoms of dryness and discomfort. Methods 49 adapted CL wearers and 15 non-lens wearing controls had room temperature pneumatic thresholds measured using a custom Belmonte esthesiometer, during Visits 1 and 2 (Baseline CL), Visit 3 (2 weeks no CL wear) and Visit 4 (2 weeks after resuming CL wear). CL wearers were subdivided into symptomatic and asymptomatic groups based on comfortable wearing time (CWT) and CLDEQ-8 score (<8 hours CWT and ≥14 CLDEQ-8 stratified the symptom groups). Detection thresholds were estimated using an ascending method of limits and each threshold was the average of the three first-reported flow rates. The magnitude of intensity, coolness, irritation and pain at detection of the stimulus were estimated using a 1-100 scale (1 very mild, 100 very strong). Results In all measurement conditions, the symptomatic CL wearers were the most sensitive, the asymptomatic CL wearers were the least sensitive and the control group was between the two CL wearing groups (group factor p < 0.001, post hoc asymptomatic vs. symptomatic group, all p’s < 0.015). Similar patterns were found for the estimated magnitude of intensity and irritation (group effect p=0.027 and 0.006 for intensity and irritation, respectively) but not for cooling (p>0.05) at detection threshold. Conclusions Symptomatic CL wearers have higher cold detection sensitivity and report greater intensity and irritation sensation at stimulus detection than the asymptomatic wearers. Room temperature pneumatic esthesiometry may help to better understand the process of sensory adaptation to CL wear.

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Corneal sensitivity in health and disease

Cited by 22 publications

References 17 publications

Corneal Sensitivity in Keratoconus after Penetrating and Deep Anterior Lamellar Keratoplasty

Corneal Sensitivity in Keratoconus after Penetrating and Deep Anterior Lamellar Keratoplasty

The anterior segment of the eye in diabetes

Hypersensitivity to Cold Stimuli in Symptomatic Contact Lens Wearers

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