Corneal Perforation Secondary to UV Radiation From a Tanning Lamp

Funnell, C L; Watson, K. C.; Stewart, Owen G.; Dua, Gurcharan

doi:10.1097/01.ico.0000240092.20849.e3

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…Consequently, geographic regions which provide increased exposure to solar UV radiation (increasing with temperature, lack of rain and elevation above sea level), may be associated with increased prevalence of keratoconus independently of or in conjunction with genetic predisposition. Tanning lamps are another source of excessive UV exposure, even with closed lids and a rare complication, such as corneal perforation in an eye with keratoconus suggest that keratoconic eyes may be more susceptible to this form of trauma. In addition to geographic location, increased exposure to UV associated with vocation or leisure activities may be important considerations.…”

Section: The Potential Significance Of Asymmetry In Keratoconusmentioning

confidence: 99%

Screening for keratoconus suspects among candidates for refractive surgery

McMonnies

2014

Clinical and Experimental Optometry

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This review examines methods for estimating the risk of post‐surgical ectasia in candidates for refractive surgery by establishing a diagnosis of keratoconus suspect as a contraindication for proceeding with surgery. Notwithstanding the desirability of achieving 100 per cent sensitivity, any associated reduction in specificity and increased numbers of false positives might deny some candidates the opportunity to proceed with refractive surgery. The introduction of a model for the risk of ectasia involving both pre‐ and post‐surgical findings has been followed by a plethora of attempts to achieve the same purpose based on topographic and/or tomographic evaluation before surgery. The desirability of being able to depend on objective assessment using one type of instrument needs to be weighed against the possibility that subjective assessments may contribute significantly to screening success. For example, consideration of ethnicity, family history of keratoconus, a history of atopy or ocular allergies in particular, a history of significant exposure to corneal trauma associated with abnormal rubbing habits or with vocational, leisure or geographically increased exposure to ultraviolet radiation or with contact lens wear trauma or a history of significant exposure to activities which elevate intraocular pressure may improve screening success. To the extent that these factors could contribute to increased risk of the development of keratoconus, they may be useful in estimating the risk of post‐surgical ectasia. If any combination of these factors helps to explain the development of keratoconus in normal or even thicker than normal corneas, they may have more significance for those corneas, which have been thinned surgically.

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Section: The Potential Significance Of Asymmetry In Keratoconusmentioning

confidence: 99%

Screening for keratoconus suspects among candidates for refractive surgery

McMonnies

2014

Clinical and Experimental Optometry

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“…KTCN is thought to be a multifactorial disorder, which involves the participation of both environmental and genetic factors. Among the environmental factors, frequent eye rubbing[ 3 ] and contact lenses wearing[ 4 ] as well UV[ 5 , 6 ] are mentioned. Also, in some reports, coexistence of KTCN with atopy and allergy was presented.…”

Section: Introductionmentioning

confidence: 99%

Nonrandom Distribution of miRNAs Genes and Single Nucleotide Variants in Keratoconus Loci

Nowak

Gajęcka

2015

PLoS ONE

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Despite numerous studies, the causes of both development and progression of keratoconus remain elusive. Previous studies of this disorder focused mainly on one or two genetic factors only. However, in the analysis of such complex diseases all potential factors should be taken into consideration. The purpose of this study was a comprehensive analysis of known keratoconus loci to uncover genetic factors involved in this disease causation in the general population, which could be omitted in the original studies. In this investigation genomic data available in various databases and experimental own data were assessed. The lists of single nucleotide variants and miRNA genes localized in reported keratoconus loci were obtained from Ensembl and miRBase, respectively. The potential impact of nonsynonymous amino acid substitutions on protein structure and function was assessed with PolyPhen-2 and SIFT. For selected protein genes the ranking was made to choose those most promising for keratoconus development. Ranking results were based on topological features in the protein-protein interaction network. High specificity for the populations in which the causative sequence variants have been identified was found. In addition, the possibility of links between previously analyzed keratoconus loci was confirmed including miRNA-gene interactions. Identified number of genes associated with oxidative stress and inflammatory agents corroborated the hypothesis of their effect on the disease etiology. Distribution of the numerous sequences variants within both exons and mature miRNA which forces you to search for a broader look at the determinants of keratoconus. Our findings highlight the complexity of the keratoconus genetics.

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“…Dentre as patologias causadas por radiação UV devemos destacar as patologias oftalmológicas sendo que dentre elas a catarata é a patologia mais importante do ponto de vista de saúde pública 74,75 . Para ilustrar os danos causados à córnea por exposição à radiação UV emitida por fontes artificiais podemos citar um caso de perfuração de córnea de um paciente após 30 minutos de exposição aguda a fontes de UV em equipamentos de bronzeamento artificial reportado por Funnell e colegas 76 . O uso de equipamentos de bronzeadores solares por jovens na procura de se enquadrar em modelos de beleza tem preocupado especialistas no mundo todo, que lançam alertas sobre os riscos destes 21 I In nt tr ro od du uç çã ão o procedimentos e da exposição à radiação UV de jovens e adolescentes 77 .…”

Section: Radiação E Dosimetria Uvunclassified

Efeito da matriz no comportamento fotocrômico de ormosils de fosfotungstato

Carvalho¹

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Corneal Perforation Secondary to UV Radiation From a Tanning Lamp

Abstract: With an increased understanding of the pathophysiology of UV damage, treatment should be aimed at modulating the disease to reduce the likelihood of a poor outcome.

Cited by 8 publications

References 12 publications

Screening for keratoconus suspects among candidates for refractive surgery

Screening for keratoconus suspects among candidates for refractive surgery

Nonrandom Distribution of miRNAs Genes and Single Nucleotide Variants in Keratoconus Loci

Efeito da matriz no comportamento fotocrômico de ormosils de fosfotungstato

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