Corneal oedema after phacoemulsification in the early postoperative period: A qualitative comparative case-control study between diabetics and non-diabetics

Tsaousis, Konstantinos T.; Panagiotou, Dimitrios; Kostopoulou, Eirini; Vlatsios, Vasileios; Stampouli, Despoina

doi:10.1016/j.amsu.2015.12.047

Cited by 24 publications

(21 citation statements)

References 24 publications

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“…Cataract surgery may bring about an increase in corneal thickness and in endothelial cell loss compared to non-diabetic patients (Langwińska-Wośko et al, 2004; Morikubo et al, 2004; Lee et al, 2005; Hugod et al, 2011; Yang et al, 2011; Dhasmana et al, 2014). Corneal edema after phacoemulsification during cataract surgery is also more persistent in diabetics (Tsaousis et al, 2015) who are also at higher risk of graft failure in Descemet's membrane keratoplasty (Greiner et al, 2014). …”

Section: General Manifestations Of Diabetes In the Corneamentioning

confidence: 99%

Diabetic complications in the cornea

2017

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Diabetic corneal alterations, such as delayed epithelial wound healing, edema, recurrent erosions, neuropathy/loss of sensitivity, and tear film changes are frequent but underdiagnosed complications of both type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus. The disease affects corneal epithelium, corneal nerves, tear film, and to a lesser extent, endothelium, and also conjunctiva. These abnormalities may appear or become exacerbated following trauma, as well as various surgeries including retinal, cataract or refractive. The focus of the review is on mechanisms of diabetic corneal abnormalities, available animal, tissue and organ culture models, and emerging treatments. Changes of basement membrane structure and wound healing rates, the role of various proteinases, advanced glycation end products (AGEs), abnormal growth and motility factors (including opioid, epidermal, and hepatocyte growth factors) are analyzed. Experimental therapeutics under development, including topical naltrexone, insulin, inhibitors of aldose reductase and AGEs, as well as emerging gene and cell therapies are discussed in detail.

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Section: General Manifestations Of Diabetes In the Corneamentioning

confidence: 99%

Diabetic complications in the cornea

2017

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“…[ 33 ] The amount of ultrasonic energy required for emulsification is strongly dependent on the density of the cataract, despite that fact the consumed energy is not the determining factor for the corresponding severity of corneal edema, which is more a function of the endothelial cell viability. [ 34 35 ]…”

Section: Morphological Changesmentioning

confidence: 99%

Corneal edema after phacoemulsification

Sharma

Singhal

Nair

et al. 2017

Indian J Ophthalmol

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Phacoemulsification is the most commonly performed cataract surgery in this era. With all the recent advances in investigations and management of cataract through phacoemulsification, most of the patients are able to achieve excellent visual outcome. Corneal edema after phacoemulsification in the immediate postoperative period often leads to patient dissatisfaction and worsening of outcome. Delayed onset corneal edema often warrants endothelial keratoplasty. This review highlights the etiopathogenesis, risk factors, and management of corneal edema in the acute phase including descemet's membrane detachment (DMD) and toxic anterior segment syndrome. Various investigative modalities such as pachymetry, specular microscopy, anterior segment optical coherence tomography, and confocal microscopy have been discussed briefly.

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“…The corneal endothelial cells are known to be susceptible to surgical insults in diabetes. The number of corneal endothelial cells is prone to reduce in diabetic eyes compared to that in nondiabetic eyes after cataract surgery 17,18. Therefore, the intravitreal injection of aflibercept may place significant stress on the corneal endothelial cells of diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

<p>Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study</p>

Muto

Machida

2019

OPTH

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Purpose To determine the effect of intravitreal aflibercept injection on the corneal endothelium in patients with diabetic or cystoid macular edema caused by retinal vein occlusion. Material and methods Forty-six eyes of 44 consecutive patients (27 men, 17 women; age range: 55–88 years) were evaluated. All participants initially received a single intravitreal injection of aflibercept (2 mg in 0.05 mL), followed by pro re nata use and underwent central corneal specular microscopy before the injection and at 1, 3 and 6 months after the first injection during a 6-month follow-up period. The endothelial cell density (ECD), average cell size (AVG), standard deviation of cell size (SD), coefficient of variation of cell size (CoV), maximum of cell size (MAX), minimum of cell size (MIN) and percentage of hexagonal cells (Hex%) were analyzed and the central corneal thickness (CCT) was measured. Results No significant differences in the ECD, AVG, SD, CoV, MIN, Hex% and CCT were observed between measurements obtained before and 1, 3 and 6 months after the first injection. However, the MAX measured before injection differed significantly from the values measured at 1, 3 and 6 months after the first injection ( P =0.033). An average of 1.43±0.58 intravitreal aflibercept injections were administered per patient. Conclusion These study findings indicate that the intravitreal administration of aflibercept (2 mg) might very slightly alter the corneal endothelium within 6 months of the first injection.

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Corneal oedema after phacoemulsification in the early postoperative period: A qualitative comparative case-control study between diabetics and non-diabetics

Cited by 24 publications

References 24 publications

Diabetic complications in the cornea

Diabetic complications in the cornea

Corneal edema after phacoemulsification

<p>Effect of intravitreal aflibercept on corneal endothelial cells: a 6-month follow-up study</p>

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