1995
DOI: 10.1097/00003226-199511000-00014
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Corneal Neovascularization After Penetrating Keratoplasty

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Cited by 48 publications
(49 citation statements)
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“…It is a major complication of corneal injury from chemical burns due to accidental exposure to solvents, detergents and alkali, and of corneal infections including bacterial, chlamydial, parasitic and viral infections which affect more than 450 million people worldwide [1,2] . In addition, corneal neovascularization represents a major reason for corneal graft rejection [3] .…”
Section: Introductionmentioning
confidence: 99%
“…It is a major complication of corneal injury from chemical burns due to accidental exposure to solvents, detergents and alkali, and of corneal infections including bacterial, chlamydial, parasitic and viral infections which affect more than 450 million people worldwide [1,2] . In addition, corneal neovascularization represents a major reason for corneal graft rejection [3] .…”
Section: Introductionmentioning
confidence: 99%
“…In normal corneas, angiogenesis is controlled by two counterbalancing systems: proangiogenic factors (vascular endothelial growth factor [VEGF], basic fibroblast growth factor, matrix metalloproteinases, integrins, and cytokines) and antiangiogenic factors (pigment epithelium-derived factor, VEGFR3, soluble VEGFR-1, angiostatin, and endostatin) (19,20). Antiangiogenic therapy may prove a promising direction to reduce graft failure (21). Various chemical compounds and drugs, such as steroids (22), methotrexate (23), heparin (24), and thalidomide (25), are reported to inhibit corneal neovascularization.…”
mentioning
confidence: 99%
“…10.1) (Cursiefen et al 2003). Even in the low-risk setting of corneal transplantation without preexisting corneal blood and lymphatic vessels, moderate (mainly iatrogenic) corneal hem-and lymphangiogenesis develops after grafting and can even reach the host-graft interface under certain circumstances, also increasing the risk for subsequent immune-mediated graft rejection (Cursiefen et al 2002a;Cursiefen et al 2001;Dana et al 1995).…”
Section: Importance Of Hem-versus Lymphangiogenesis In Corneal Transpmentioning
confidence: 99%