Corneal Involvement in Uneventful Cataract Surgery: An in vivo Confocal Microscopy Study

Cillà, Stefano De; Fogagnolo, Paolo; Sacchi, Matteo; Orzalesi, N.; Carini, Elisa; Ceresara, Gaia; Rossetti, Luca

doi:10.1159/000355490

Cited by 26 publications

(23 citation statements)

References 31 publications

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“…Two of the most relevant risk factors for DED are anterior segment surgery [3,16,17] and increased age [3]. As cataract surgery is commonly performed on the elderly, DED frequently occurs after this procedure.…”

Section: Discussionmentioning

confidence: 99%

New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study

et al. 2020

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Introduction: To evaluate the effects of a new lubricating, antioxidant solution (VisuEvo Ò) on dry eye disease (DED) in patients undergoing cataract surgery. Methods: Patients requiring cataract surgery with either healthy ocular surface or mild DED (tear break-up time, TBUT [ 7, Schirmer I test [ 15 mm/5 min) were enrolled in this multicenter, open-label, randomized, prospective study. Scheduled visits were 2 weeks before surgery (screening), day of surgery (V0), week 1 (V1), and 2 (V2) after surgery. VisuEvo Ò was selfadministered three times daily for the whole study duration (group A); the control group (group B) had no tear substitute administration. The primary endpoint was the change in TBUT over time; the secondary endpoints were changes in Ocular Surface Disease Index (OSDI), ocular surface staining, the Schirmer I test, and osmometry. Results: A total of 45 patients were included (group A, 23; group B, 22; age 74 ± 8 years). At the screening, TBUT was similar between the groups (group A, 8.5 ± 1.8 s; group B, 7.8 ± 0.7, p = 0.11). At the scheduled visits, TBUT increase vs screening visit was significantly higher in group A: ?1.2 s at V0, ?1.4 s at V1, and ?1.9 s at V2 (p \ 0.01). Also, OSDI was significantly lower in group A at V0, V1, and V2 (p \ 0.027). After surgery, corneal staining was absent in 65-78% of group A compared with 54-59% in group B. The two groups did not show any significant differences of osmometry and the Schirmer I test. Conclusions: The ocular surface was more protected and quickly restored from surgery when VisuEvo Ò was used from 2 weeks preoperatively to 2 weeks postoperatively. Trial registration: ClinicalTrials.gov identifier, NCT03833908

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Section: Discussionmentioning

confidence: 99%

New Therapeutic Strategy and Innovative Lubricating Ophthalmic Solution in Minimizing Dry Eye Disease Associated with Cataract Surgery: A Randomized, Prospective Study

et al. 2020

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“…16,21,22 Even after uneventful cataract surgery, transient nerve alterations can be detected. 23 Moreover, fullthickness PK transects all corneal nerves in both the host and donor cornea. 16 However, this study demonstrates strong diminishment of the density and function of the subbasal corneal nerve plexus even after DMEK surgery.…”

Section: Discussionmentioning

confidence: 99%