Corneal Higher-Order Aberrations in Infectious Keratitis

Shimizu, Eisuke; Yamaguchi, Takefumi; Yagi-Yaguchi, Yukari; Doğru, Murat; Satake, Yoshiyuki; Ohta, Michio; Shimazaki, Jun

doi:10.1016/j.ajo.2016.12.014

Cited by 22 publications

(26 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Infectious keratitis can cause topographic changes resulting in visual impairment. This phenomenon was recently investigated, and tomographic measurements of post-infected corneas revealed different patterns of corneal aberrations including protrusion keratoconus-like patterns [ 5 , 6 ].…”

Section: Resultsmentioning

confidence: 99%

“…In recent studies, the effect of infectious keratitis on corneal topography was investigated [ 5 , 6 ]. The topographic changes due to infectious keratitis seem to depend on the location of the inflammation and the healing response of the host.…”

Section: Discussionmentioning

confidence: 99%

“…The topographic changes due to infectious keratitis seem to depend on the location of the inflammation and the healing response of the host. Although asymmetric patterns appeared to be the most common, protrusion patterns were also revealed [ 5 ]. The pathogenesis of these changes has not been elucidated yet, but the first patterns may be associated to stiffening of the inflamed cornea due to a predominance of scarring process, whereas the second, keratoconus-like patterns would arise through stromal melting.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of these changes has not been elucidated yet, but the first patterns may be associated to stiffening of the inflamed cornea due to a predominance of scarring process, whereas the second, keratoconus-like patterns would arise through stromal melting. Optical aberrations caused by topographic changes of the cornea were revealed, as well as corneal opacification, to be responsible for visual impairment following infectious keratitis [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Keratoconus-like tomographic changes in a case of recurrent interstitial keratitis

Hanet

Zimpfer

Lepper

et al. 2018

J Ophthal Inflamm Infect

View full text Add to dashboard Cite

BackgroundThe purpose of this report was to describe a single case of recurrent interstitial keratitis in a young patient leading to keratoconus-like corneal changes.ResultsOver the 2 years follow-up, the patient developed clinical signs of keratoconus with Vogt’s striae, Fleischer Ring and paracentral stromal thinning in the affected eye only. The tomographic measurements revealed a rapid reduction of corneal thickness from 581 to 303 μm and an irregular steepening of the pathological cornea. True net corneal power increased from 42.8 to 48.8 dioptres (D) and maximal power of the anterior surface from 44.9 to 66.9 D. Best-corrected visual acuity (BCVA) decreased from 20/20 to 20/200. A penetrating excimer laser keratoplasty was performed to restore vision and corneal stability.ConclusionKeratoconus-like changes can occur in young patients with recurrent interstitial keratitis and request corneal transplantation.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Keratoconus-like tomographic changes in a case of recurrent interstitial keratitis

Hanet

Zimpfer

Lepper

et al. 2018

J Ophthal Inflamm Infect

View full text Add to dashboard Cite

show abstract

“…Recent studies have measured and characterized typical higher‐order aberrations (HOAs) patterns in eyes with mild to moderate corneal opacities, such as corneal dystrophies, bullous keratopathy and corneal scarring due to infectious keratitis (Shimizu et al. ,; Yamaguchi et al. ; Yazu et al.…”

Section: Discussionmentioning

confidence: 99%

Quantitative evaluation of visual function in patients with cornea verticillata associated with Fabry disease

Koh

Haruna

Asonuma

et al. 2019

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose: To evaluate the visual function of patients with cornea verticillata associated with Fabry disease through quantitative evaluations of contrast sensitivity function and straylight. Methods: We enrolled 28 eyes of 14 patients with Fabry disease (mean age, 37.1 AE 17.2 years) and 20 eyes of 20 age-matched healthy controls. Comprehensive ophthalmological examinations were performed and contrast sensitivity and letter contrast sensitivity were measured for all patients, following which the area under the log contrast sensitivity function (AULCSF) was calculated. Straylight was quantified using a straylight metre. Furthermore, subgroup analysis was performed according to the whorl-like pattern of cornea verticillata (mild and typical groups). Results: All 28 eyes showed cornea verticillata. Visual acuity and letter contrast sensitivity values were the same for normal eyes and those with Fabry disease. AULCSF differed by 0.15 log[s] between the eyes with Fabry disease and the control eyes (p < 0.001), while straylight differed by 0.45 log[s] between the two groups (p < 0.001). Subgroup analysis based on the whorl-like pattern of cornea verticillata showed that AULCSF and straylight differed by 0.11 log[s] and 0.08 log[s], respectively, between the typical and mild groups (p = 0.036 and p = 0.147, respectively). Conclusion: Although cornea verticillata associated with Fabry disease does not affect the visual acuity and letter contrast sensitivity, more comprehensive testing of visual function by the inclusion of straylight and grating contrast sensitivity measurements shows clear functional deficits in these patients.

show abstract

Quantitative evaluation of corneal irregularity and scarring after infectious keratitis using anterior segment optical coherence tomography

Ichikawa,

Ono,

Chen

et al. 2023

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Purpose Corneal scars after infectious keratitis lead to insufficient transparency and irregular astigmatism, affecting visual acuity; therefore, they should be accurately evaluated to estimate visual function. This study aimed to quantitatively evaluate corneal irregularity and scarring after infectious keratitis using anterior segment optical coherence tomography (AS-OCT). Methods This was an observational clinical study. We included patients who had corneal scarring after treatment of infectious keratitis between 2014 and 2021 at University of Tokyo Hospital. We retrospectively examined best spectacle-corrected visual acuity (BSCVA), average keratometric power, central corneal thickness (CCT), and four components of the Fourier harmonic analysis including spherical and asymmetry components, as well as regular astigmatism and higher-order irregularity. We included anterior and posterior corneal data and compared results with those of contralateral healthy eyes. Additionally, we quantitatively evaluated the densitometry of the cornea obtained using AS-OCT. Results A total of 122 eyes of 61 patients were examined; male predominance was observed (n = 37), and the mean patient age was 55.3 ± 19.4 years. Comparisons with contralateral healthy eyes showed that BSCVA worsened (0.30 ± 0.83 and 0.93 ± 1.36 logMAR, respectively, P = 0.003), and CCT (531.1 ± 46.2 and 591.8 ± 132.4 μm, respectively, P < 0.001) and corneal densitometry (84.4 ± 11.8 and 111.9 ± 19.2 grayscale units, respectively, P < 0.001) increased significantly in affected eyes. The asymmetry component and higher-order irregularities that were not corrected with spectacles significantly increased (both P < 0.001), and there were no significant differences in the changes among the bacterial, fungal, herpetic, and acanthamoeba types of keratitis. Conclusion Corneal scarring persisted after treatment for infectious keratitis, and the asymmetry and irregularities of corneal astigmatism increased as visual acuity deteriorated. AS-OCT with the Fourier harmonic analysis was useful for evaluating corneal topographic changes in patients with corneal scarring after keratitis.

show abstract

Corneal Higher-Order Aberrations in Infectious Keratitis

Cited by 22 publications

References 25 publications

Keratoconus-like tomographic changes in a case of recurrent interstitial keratitis

Keratoconus-like tomographic changes in a case of recurrent interstitial keratitis

Quantitative evaluation of visual function in patients with cornea verticillata associated with Fabry disease

Quantitative evaluation of corneal irregularity and scarring after infectious keratitis using anterior segment optical coherence tomography

Contact Info

Product

Resources

About