ABSTRACT.Purpose: We aimed to compare the Haag-Streit optical low-coherence reflectometry (OLCR) pachymeter and the Zeiss Anterior Chamber Master (ACMaster) for measuring central corneal thickness (CCT) in high myopes and after laser in situ keratomileusis (LASIK) for myopia. Methods: Central corneal thickness was measured in 55 eyes of 30 myopic subjects (spherical equivalent refraction of ) 5.25 D to ) 10.75 D, maximal astigmatism of ) 2 D), and in 37 eyes of 21 patients 3 months after LASIK for myopia (preoperative spherical equivalent refraction of ) 6.0 D to ) 10.75 D, maximal astigmatism of ) 2 D). All measurements were performed with the Haag-Streit OLCR pachymeter and the Zeiss ACMaster, using group refractive indices of 1.376 and 1.3851, respectively. Thickness measurements were compared using paired t-tests, Pearson's correlation, linear regression and Bland)Altman plots. Results: In myopic subjects, CCT measured 531 ± 28 lm and 533 ± 27 lm with the OLCR pachymeter and the ACMaster, respectively (p < 0.01); all measurements correlated closely (r = 0.99, p < 0.01). In LASIK-treated eyes, CCT measured 472 ± 24 lm using the OLCR pachymeter and 475 ± 23 lm using the ACMaster (p < 0.01), again with close correlation between the two instruments (r = 0.99, p < 0.01). Conclusions: Measurements of CCT in high myopes and after myopic LASIK were very similar with the Haag-Streit OLCR pachymeter and the Zeiss ACMaster. Using the current group refractive indices, the observed difference between the two instruments of < 3 lm is of little clinical importance. Thus, it would seem safe to use the OLCR pachymeter and the ACMaster interchangeably for CCT measurements in myopia as well as after myopic LASIK.