Corneal Fluorescein Staining Correlates with Visual Function in Dry Eye Patients

Kaido, Minako; Matsumoto, Yukihiro; Shigeno, Yuta; Ishida, Ryôhei; Doğru, Murat

doi:10.1167/iovs.11-8412

Cited by 107 publications

(83 citation statements)

References 40 publications

(44 reference statements)

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“…DED affects visual quality by worsening tear-related aberration changes, and impaired visual performance could lead to depression and lower QoL. [24][25][26] Ocular pain and discomfort without a definitely impaired tear film could also result in depression, anxiety, and psychological stress. Unlike the previous studies, our study results indicated that both clinically diagnosed DED and symptoms of DED showed significantly different prevalence and intensity of all the psychological parameters.…”

Section: Discussionmentioning

confidence: 99%

Depression, Stress, Quality of Life, and Dry Eye Disease in Korean Women

Han

Park

et al. 2015

Cornea

119

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Section: Discussionmentioning

confidence: 99%

Depression, Stress, Quality of Life, and Dry Eye Disease in Korean Women

Han

Park

et al. 2015

Cornea

119

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“…[25][26][27][28][29][30] Sequential measurements of corneal or ocular wavefront aberrations in normal eyes and dry eyes have revealed that dynamic changes in the tear film affect the postblink optical quality. [31][32][33][34][35][36][37][38][39][40][41][42] Moreover, the double-pass system is capable of monitoring postblink dynamic changes in optical quality associated with changes in the tear film. [43][44][45][46][47] Previous investigations using sequential HOA measurements showed that postblink dynamic changes in optical quality occur even in clinically normal subjects and revealed that such postblink changes in dry eyes can be classified into two patterns.…”

Section: Accommodationmentioning

confidence: 99%

Overview of Objective Methods for Assessing Dynamic Changes in Optical Quality

Koh

Higashiura

Maeda

2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Quality of vision has been emphasized in ophthalmologic clinical practice in recent years. The optical or visual performance of the human eye is not static and fluctuates over time. Considering the major origins of temporal fluctuations in optical or visual performance, quantitative assessment of the dynamic changes in the optical quality of the entire eye is important. This review provides an overview of the clinical application of the objective methods for assessing dynamic changes in optical quality, particularly those associated with accommodation, the precorneal tear film, the prelens tear film, and contact lens movement and fitting.

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“…Dry eye causes ocular discomfort and irritation, but also decreases functional visual acuity, which potentially interferes with work efficiency. [4][5][6][7] Although new treatments such as the P2Y2 agonist or cyclosporine have been developed along with the widely used punctal plug application, which have obtained a certain level of patient satisfaction, 8,9 there is no fundamental treatment for dry eye that recovers lacrimal functions to normal levels. Therefore, the key question for the development of novel treatments is what kind of new research approach should we take?…”

mentioning

confidence: 99%

The Antiaging Approach for the Treatment of Dry Eye

Tsubota

Kawashima

Inaba

et al. 2012

Cornea

Self Cite

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Dry eye is one of the most common eye disorders affecting millions of people. It causes ocular irritation or discomfort, and decreases functional vision, causing a dramatic deterioration in the quality of life. Although new treatments such as the P2Y2 agonist or cyclosporine eye drops have been developed and a certain level of patient satisfaction can now be obtained, no fundamental treatment has been developed. Currently, there is no therapy available to recover lacrimal function to its normal status. Recent progress in the understanding of aging has laid the foundations for a new way of thinking about intervention of the aging process. Because dry eye is accelerated by aging, a useful approach for the prevention or treatment of dry eye may be to interfere with the aging process. In the scientific community, there is a global consensus that calorie restriction can extend the life span of various kinds of animals, establishing an intervention to aging. Another important hypothesis believed to be involved in aging is the free radical theory. According to these theories, the aging process may be managed by controlling levels of calories or reactive oxygen species. In this review, these 2 important aging theories, calorie restriction and free radical aging, are examined, and we discuss how to apply these theories to the prevention and treatment of dry eye.

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Corneal Fluorescein Staining Correlates with Visual Function in Dry Eye Patients

Abstract: Optical disturbances at the central optical zone of the cornea in dry eye disease may affect visual performance. Functional VA measurement may be an applicable method of evaluating visual performance in dry eyes that is as efficient as wavefront aberration measurements.

Cited by 107 publications

References 40 publications

Depression, Stress, Quality of Life, and Dry Eye Disease in Korean Women

Depression, Stress, Quality of Life, and Dry Eye Disease in Korean Women

Overview of Objective Methods for Assessing Dynamic Changes in Optical Quality

The Antiaging Approach for the Treatment of Dry Eye

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