Corneal Epithelial Iron Deposition

Barraquer-Somers, Elena; Chan, Chi Chao; Green, W. Richard

doi:10.1016/s0161-6420(83)34519-x

Cited by 42 publications

(15 citation statements)

References 6 publications

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“…These lines have been found in up to 90% of randomly selected normal eye-bank eyes. 63 A similar line curving around the front of a pterygium is known as Stocker's line,64 and Ferry described curvilinear iron deposition at the base of a filtering bleb.6s Fleischer's ring either completely or partially surrounds the base of a cone in keratoconus,66 and, as with all such iron lines, may be best appreciated with broad cobalt blue illumination. The mechanism of formation of such lines is not clear, although many hypotheses have been put forward.…”

Section: Patterns Of Superficial Keratopathymentioning

confidence: 99%

Patterns of Superficial Keratopathy

Roussel

Grutzmacher

Coster

1984

Australian Journal of Opthalmology

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Section: Patterns Of Superficial Keratopathymentioning

confidence: 99%

Patterns of Superficial Keratopathy

Roussel

Grutzmacher

Coster

1984

Australian Journal of Opthalmology

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“…The early morphological changes seen in keratoconus include vertical stress lines or Vogt's bands in the deep stroma and Descemet's membrane, with subsequent thinning of the stromal layer and focal central defects of Bowman's layer with facet formation [5], Epi thelial iron deposition is variably noted at the base of the 'cone' [22]. As the stromal layer continues to thin and scar, Descemet's mem brane may develop striae, tears and denudement that may eventually result in severe stro mal and epithelial edema (corneal hydrops) [23][24][25].…”

Section: ]-mentioning

confidence: 99%

Pathology of Corneal Endothelium in Keratoconus

Sturbaum¹,

Peiffer²

1993

Ophthalmologica

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Keratoconus is characterized by stromal thinning and conical deformity of the cornea that affects a small but significant portion of the population. Although keratoconus has been well studied, endothehal changes have not been extensively investigated. We studied the endothelium of 14 keratoconus corneal buttons obtained over the past 6 years by penetrating keratoplasty using light microscopy, scanning electron microscopy and transmission electron microscopy. Observations were correlated with patient history. Corneas demonstrated: endothehal cell pleomorphism and polymegathism (6 corneas); endothehal cell degeneration (13), and evidence of anterior chamber inflammation (4). Patterns of endothehal damage were variable ranging from isolated cell membranolysis to denudement of Descemet’s membrane. Less damage was present at the apex of the cones than that observed in a circumferential pattern at the bases. In general the damage observed correlated with the severity and duration of the keratoconus with 9 years being the dividing time between mild and severe endothehal cell damage. These observations support other studies that implicate contact lens wear as a cause of pleomorphism and polymegathism in these patients. Endothehal cell alterations are likely a secondary event occurring due to mechanical stresses.

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“…Barraquer-Somers and associates used Prussian blue stain on recipient penetrating keratoplasty buttons to reveal iron deposition predominantly in the deeper layers of the epithelium. 21 This pattern was most closely linked with scenarios such as the Hudson-Stähli line or Fleischer ring, where the rust-brown pigment was clinically arranged in irregular curvilinear configurations. Less commonly, iron deposits stained diffusely through all layers of the epithelium in a fine stippled pattern.…”

Section: Discussionmentioning

confidence: 90%

“…This seemed to occur more often with diffuse corneal scars secondary to keratitis, chemical burns, or mechanical trauma, according to the same study. 21 The exact pathophysiologic mechanism by which iron is deposited in the corneal epithelium is still unknown and frequently debated. Several theories have been presented, mainly focused on the tear film and the replication/migration of the corneal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%