Corneal Endothelium in Patients with Anterior Uveitis

Alfawaz, Abdullah M.; Holland, Gary N.; Yu, Fei; Margolis, Mathew; Giaconi, JoAnn A.; Aldave, Anthony J.

doi:10.1016/j.ophtha.2016.04.036

Cited by 80 publications

(59 citation statements)

References 30 publications

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“…7,21 Regarding chronic inflammation of the anterior chamber, a previous study that used laser flare photometry reported a correlation between ECD and flare in the anterior chamber of eyes with a history of uveitis. 6 Elevated flare can persist in people with a history of uveitis, even after the resolution of anterior chamber cells. 43 However, the laser flare photometer cannot identify specific proteins.…”

Section: Figurementioning

confidence: 99%

“…17 ECD is lower in eyes with a history of uveitis and is correlated with the flare in the anterior chamber, suggesting that environmental factors in the AqH can directly influence the survival of endothelial cells. 6 However, to the best of our knowledge, the association between reduced ECD and cytokine levels in the AqH is poorly understood. We hypothesized that elevation of proinflammatory cytokines in the AqH is associated with a decrease in ECD.…”

mentioning

confidence: 99%

“…[4][5][6] The reduction of ECD is exacerbated over time after intraocular surgery, [7][8][9] and is a serious complication after corneal transplantation because it may lead to endothelial decompensation and loss of vision. [10][11][12] Risk factors for postoperative endothelial cell loss after penetrating keratoplasty (PKP) include donor age, recipient age, graft diameter, lens status, glaucoma, graft rejection, and peripheral corneal diseases.…”

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confidence: 99%

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Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density

Yamaguchi

Higa

Suzuki

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Section: Figurementioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density

Yamaguchi

Higa

Suzuki

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…[14][15][16] In a previous study, 17 a combination of proinflammatory cytokines were observed to synergistically induce the apoptosis of corneal endothelial cells in vitro. In addition, ECDs are lower in eyes with a history of uveitis, and are correlated with flare in the anterior chamber, 18 suggesting that inflammatory factors in AqH directly influence ECD. Thus, we hypothesized that the iris damage might be associated with increased cytokine levels in AqH.…”

mentioning

confidence: 99%

Iris Damage Is Associated With Elevated Cytokine Levels in Aqueous Humor

Aketa

Yamaguchi

Suzuki

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To evaluate the association between iris damage and cytokine levels in the aqueous humor (AqH). METHODS.A total of 201 AqH samples from 201 consecutive patients (mean age 73.7 6 10.6) were collected at the beginning of corneal transplantation or cataract surgery. Iris damage of each case was assessed from preoperative slit-lamp findings based on its severity. The subjects were classified into three groups: eyes without iris damage (126 eyes), eyes with mild iris damage (51 eyes), and eyes with severe iris damage (24 eyes RESULTS. The levels of aqueous protein, IL-1a, IL-1b, IL-4, IL-6, IL-8, IL-10, IL-17A, MCP-1, TNF-a, E-selectin, P-selectin, and sICAM-1 in eyes with mild and severe iris damage were higher than in those without iris damage (P < 0.033). Multivariate analyses of clinical factors revealed that iris damage was associated with the history of complicated glaucoma, and the number of previous intraocular surgeries. The levels of AqH IL-6, IL-8, IL-13, MIP1a, TNF-a, and sICAM-1 were significantly elevated in eyes with mild and severe iris damage in phakic eyes, and the levels of AqH IL-8 and sICAM-1 were significantly elevated in eyes with severe iris damage in pseudophakic eyes, compared with the eyes without iris damage (P < 0.045). CONCLUSIONS.Iris damage was associated with the elevation in the levels of aqueous protein and cytokines.

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“…The cell decline accelerates with intraocular surgeries, anterior chamber inflammation, corneal anoxia, glaucoma, and guttata dystrophy [13][14][15][16][17] . As a result of the absence of endothelium reproduction, dead cells leave vacant spaces to be filled by adjacent cells that extend or slide toward the lesion.…”

Section: Logic Of Morphological Analyses Of the Endotheliummentioning

confidence: 99%

Donor selection criteria: In Vitro Corneal Analysis

Sousa¹,

Barretto²

2018

eOftalmo

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This article focus on in vitro analysis of the endothelium of donated corneas for transplantation. It is about the influence of preservative solutions on the endothelium shape, the morphological and morphometric analyses of the endothelial layer, the cellular pattern of acute endothelial losses and its differential diagnosis, the role of endothelial morphology on the regulation of corneal hydration, and specular microscopy. RESUMOEste artigo concentra-se na análise in vitro do endotélio das córneas doadas para transplante. Ele se refere à influência das soluções preservativas sobre o aspecto do endotélio, a lógica das análises morfológicas e morfométricas do mesmo, o padrão das perdas endoteliais agudas e seu diagnóstico diferencial, a influência da morfologia endotelial sobre regulação da hidratação da corneana e a microscopia especular.

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Corneal Endothelium in Patients with Anterior Uveitis

Cited by 80 publications

References 30 publications

Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density

Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density

Iris Damage Is Associated With Elevated Cytokine Levels in Aqueous Humor

Donor selection criteria: In Vitro Corneal Analysis

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