Corneal endothelial cell density and morphology in patients with acromegaly

Hatipoğlu, Esra; Arıcı, Ceyhun; Arslan, Osman; Dikkaya, Funda; Sultan, Pınar; Kadıoğlu, Pınar; Gündoğdu, Sadi

doi:10.1016/j.ghir.2014.08.003

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…We evaluated the cell size according to various factors, such as cell density, the CV in the cell area (SD/mean), and the proportion of hexagonal cells, based on standard methods. [101112]…”

Section: Methodsmentioning

confidence: 99%

Effects of laser peripheral iridotomy on corneal endothelial cell density and cell morphology in primary angle closure suspect subjects

Jamali¹,

Jahanian²,

Gharebaghi³

2016

J Ophthalmic Vis Res

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Purpose:To evaluate the effects of prophylactic laser peripheral iridotomy on corneal endothelial cell density and cell morphology in subjects with primary angle closure suspect (PACS) within a one-year follow-up period.Methods:In this quasi-experimental prospective study, from June 2012 to November 2013, thirty-five PACS eyes underwent laser peripheral iridotomy at clinics affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. After obtaining informed consent, specular microscopy was performed at baseline and at 3-month, 6-month and 12-month follow-up visits. Central, nasal and temporal endothelial cell counts and cell morphology were evaluated via non-contact specular microscopy.Results:The mean subject age was 53.4 ± 7.9 years, and the majority of subjects were women (88.2%). The mean central corneal endothelial cell count prior to laser peripheral iridotomy was 2528 ± 119.2, and this value changed to 2470 ± 175.9, 2425 ± 150.6, and 2407 ± 69.02 at the 3-month, 6-month, and 12-month follow-up visits, respectively; these differences did not reach statistical significance. Additionally, the changes in the number of cells, the hexagonality of cells, and the coefficient of variation (CV) in the central, nasal, and temporal areas were not significant.Conclusion:In PACS eyes, we did not find a decline in corneal endothelial cell density or a change in cell morphological characteristics, including cell hexagonality and CV, in the central, nasal, and temporal regions of the cornea in any of our subjects over a one-year follow-up period.

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Section: Methodsmentioning

confidence: 99%

Effects of laser peripheral iridotomy on corneal endothelial cell density and cell morphology in primary angle closure suspect subjects

Jamali¹,

Jahanian²,

Gharebaghi³

2016

J Ophthalmic Vis Res

View full text Add to dashboard Cite

show abstract

“…The corneal endothelium is a connected single-layer of hexagonal uniformly sized cells on the posterior surface of the human cornea [6]. Several factors can damage this regular tessellation and cause cell loss, including aging, intraocular surgery, inflammation or other ocular or systemic pathologies [7]. Damage to the endothelial cells can lead to altered hydration of the corneal stroma and visual loss, which may be associated with irreversible endothelial cell pathology requiring corneal transplantation (Keratoplasty) [8].…”

Section: Introductionmentioning

confidence: 99%

“…In-vitro quantitative analysis of the corneal endothelium is currently undertaken at eye hospitals to assess the functional capacity of the corneal endothelium, and hence the quality of the donor cornea prior to transplantation [10]. A minimum Endothelial Cell Density (ECD) of 400 to 600 (cells/mm 2 ) is an indicator of corneal endothelial health and most donor corneas should have an ECD of at least 2000 (cells/mm 2 ) to be authorized for Keratoplasty [7] [11]. The corneal endothelium should also ideally have 100% Hexagonality, with 60% being accepted as an indicator of a healthy corneal endothelium [9].…”

Section: Introductionmentioning

confidence: 99%