Corneal Endothelial Cell Density and Morphology in Normal Indian Eyes

Sk, Rao; P, Ranjan Sen; Fogla, Rajesh; Gangadharan, Sidhu P.; Padmanabhan, Prema; Ss, Badrinath

doi:10.1097/00003226-200011000-00012

Cited by 119 publications

(146 citation statements)

References 18 publications

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“…[9][10][11]15,17,[21][22][23][24][25] Consistent with the majority of other published reports, there was no significant difference in mean ECD based on gender in this study. 5,9,16,17,26,27 With regards to the reliability and repeatability of the NAVIS endothelial analysis system, automated endothelial analysis often fails to correctly identify endothelial cell borders. 14,28 However, Kitzman et al 14 have demonstrated that after manual correction of cell borders detected by the NAVIS automated software, the endothelial density, coefficient of variation of cell area, and percentage of hexagonal cells were not different from those determined by the Corners method.…”

Section: Discussionsupporting

confidence: 91%

“…[15][16][17][18][19][20] When compared with mean ECD values reported for children (3400-4300 cells/mm 2 ) and for elderly eyes (2324-3175 cells/mm 2 ), a clear trend of decreasing mean ECD with advancing age is observed. [9][10][11]15,17,[21][22][23][24][25] Consistent with the majority of other published reports, there was no significant difference in mean ECD based on gender in this study. 5,9,16,17,26,27 With regards to the reliability and repeatability of the NAVIS endothelial analysis system, automated endothelial analysis often fails to correctly identify endothelial cell borders.…”

Section: Discussionmentioning

confidence: 99%

“…The mean percentage of hexagonality in this current study (53±5%) was less than that identified in two recently published reports that analysed mean percentage of hexagonality for the same age range as this study (both 61 ± 7%). 17,58 Percentage of hexagonality of the corneal endothelium has been reported to gradually decrease with advancing age. 4,8,17,58 There was no correlation between percentage of hexagonality and ECD in this study.…”

Section: Discussionmentioning

confidence: 99%

“…17,58 Percentage of hexagonality of the corneal endothelium has been reported to gradually decrease with advancing age. 4,8,17,58 There was no correlation between percentage of hexagonality and ECD in this study. However, a significant correlation was identified between decreasing percentage of hexagonality and increased variation in cell area.…”

Section: Discussionmentioning

confidence: 99%

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Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Patel

McGhee

2008

Eye

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Purpose Despite the importance of a healthy endothelial layer in anterior segment surgery, the possible influence of corneal parameters on endothelial cell density (ECD) has largely been ignored in the young adult eye. This study investigated the possible associations between corneal tomographic parameters and ECD values in young adults. Methods Subjects aged 21-30 years, with normal corneas were recruited. Mean ECD, mean cell area (MCA), coefficient of variation for cell area (COVA), and proportion of hexagonal cells were derived by in vivo confocal microscopy. The Orbscan II system was used to measure corneal parameters including: thickness, horizontal corneal diameter, corneal curvature, anterior and posterior elevation, and eccentricity. Results Sixty-two subjects (42 female, 20 male) were included (mean age 25±3 years). Overall mean ECD was 3169±309 cells/mm 2 with no differences between genders. Mean percentage of hexagonality was 53 ± 5%, male subjects (55%) had a higher percentage of hexagonal cells than female subjects (51%) (P ¼ 0.02). Central corneal thickness (CCT) was 529±43 lm. Central ECD was significantly correlated with CCT (Pearson's r ¼ 0.26, P ¼ 0.04). However, horizontal corneal diameter (r ¼ 0.19, P ¼ 0.14), anterior corneal curvature (r ¼ À0.07, P ¼ 0.6), and posterior corneal curvature (r ¼ À0.07, P ¼ 0.6) were not correlated with ECD or percentage of hexagonality. There was no statistically significant association between anterior chamber depth (3.6±0.3 mm) and ECD (r ¼ 0.15, P ¼ 0.3). Conclusion Corneal thickness is related to ECD in normal young adult eye, with lower ECD values identified in thinner corneas; however, corneal diameter and corneal curvature do not have a significant correlation with ECD.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Patel

McGhee

2008

Eye

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“…Several studies report a rate of 0.3-0.6 % endothelial cell loss per year in normal corneas [2,21,24,[28][29][30]. After intraocular surgery, the rate of endothelial cell loss is increased [2,31,32].…”

Section: Financial Interestmentioning

confidence: 99%

Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Kettesy

Németh

Kemény-Beke

et al. 2014

Wien Klin Wochenschr

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SummaryBackground Corneal transparency is a useful indicator for corneal function. Our aim was to investigate central corneal endothelial cells and corneal thickness in transplanted corneas at an average of 5.4 years after penetrating keratoplastyPatients and methods The study involved 68 perforated keratoplasty patients with at least a 1 year followup. Post-operatively, the central corneal endothelial layer was observed using a contact specular microscope. Central endothelial cell density, corneal thickness and the coefficient of variation of endothelial size were statistically analysed.Results The post-operative follow-up time was ranging from 12 months to 23 years. Endothelial cell density (ECD) was 1,501 ± 249 cell/mm 2 . The average cell size was 673.6 ± 98.3 μm 2 , and the coefficient of variation of cell size was 0.61 ± 0.11. No difference in ECD was detected between diagnostic groups. Corneal thickness was 0.56 ± 0.06 mm. Correlation between ECD and post-operative time was not significant (r = 0.02; p = 0.85).Conclusion Our study concluded that ECD showed a higher rate of decrease after penetrating keratoplasty with no relation to pre-operative diagnosis.Keywords Endothelial cell loss · graft survival · penetrating keratoplasty · specular microscope Bestimmung der Endothelzelldichte und der Hornhautdicke in Hornhauttransplantaten circa 5 Jahre nach einer penetrierenden Keratoplastik Zusammenfassung Hintergrund Die Transparenz der Cornea ist ein nütz-licher Indikator der Funktion der Hornhaut. Das Ziel unserer Studie war es, die zentralen Endothelzellen der Cornea sowie die Dicke der Hornhaut in transplantierten Hornhäuten circa 5,4 (im Durchschnitt) Jahre nach penetrierender Keratoplastik zu untersuchen.Patienten und Methoden In die Studie wurden 68 Patienten nach perforierter Keratoplastik aufgenommen, die zumindest 1 Jahr nachuntersucht worden waren. Postoperativ wurde die zentrale Endothelschicht der Hornhautmittel seines Kontakt-Spekular Mikroskops untersucht. Die Dichte der zentralen Endothelzellen, die Dicke der Hornhaut und der Variations-Koeffizient der Größe des Endothels wurden statistisch analysiert.Ergebnisse Der Zeitpunkt der postoperativen Kontrollen variierte von 12 Monaten bis 23 Jahren. Die Endothelzelldichte (EZD) lag bei 1501 ± 249 Zelle/mm 2 . Der Mittelwert der Zellgröße war 673,6 ± 98,3 μm 2 und der Variationskoeffizient 0,61 ± 0,11. Es gab keinen Unterschied in der EZD zwischen den nach Diagnosen eingeteilten Gruppen. Die Korrelation zwischen der EZD und dem Zeitabstand zur Operation war nicht kant (r = 0,02; p = 0,85).Schlussfolgerung Unsere Studie zeigt unabhängig von der präoperativen Diagnose eine abfallende Tendenz der EZD nach penetrierender Keratoplastik.

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Corneal Endothelium: Applied Anatomy

Arnalich‐Montiel

2019

Essentials in Ophthalmology

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Corneal Endothelial Cell Density and Morphology in Normal Indian Eyes

Abstract: Normative data for the endothelium in the Indian population are reported. Endothelial cell density in Indian eyes is less than the values described in the Japanese and American populations.

Cited by 119 publications

References 18 publications

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Corneal Endothelium: Applied Anatomy

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