Corneal elastosis within lattice dystrophy lesions.

Pe'er, J.; Fine, Ben S.; Dixon, Anita; Rothberg, D S

doi:10.1136/bjo.72.3.183

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…Several earlier reports noted an association of structures that both stained positive with the Verhoeff-van Gieson procedure, and exhibited characteristics of amyloid of undetermined origin in pathological conditions in the cornea [16,17] and skin [18]. The suggestion was made that "the amyloid-like filaments actually represented microfibrils of elastic tissue"[18]; however, that hypothesis has not been confirmed to our knowledge.…”

Section: Discussionmentioning

confidence: 84%

Amyloid associated with elastin-staining laminar aggregates in the lungs of patients diagnosed with acute respiratory distress syndrome

Fan

Nagle

2002

BMC Pulm Med

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BackgroundThe heterogeneity of conditions underlying respiratory distress, whether classified clinically as acute lung injury (ALI) or the more severe acute respiratory distress syndrome (ARDS), has hampered efforts to identify and more successfully treat these patients. Examination of postmortem lungs among cases clinically diagnosed as ARDS identified a cohort that showed a consistent morphology at the light and electron microscope levels, and featured pathognomonic structures which we termed elastin-staining laminar structures (ELS).MethodsPostmortem tissues were stained using the Verhoeff-Van Gieson procedure for elastic fibers, and with Congo red for examination under a polarizing microscope. Similar samples were examined by transmission EM.ResultsThe pathognomonic ELS presented as ordered molecular aggregates when stained using the Verhoeff-van Gieson technique for elastic fibers. In several postmortem lungs, the ELS also displayed apple-green birefringence after staining with Congo red, suggesting the presence of amyloid. Remarkably, most of the postmortem lungs with ELS exhibited no significant acute inflammatory cellular response such as neutrophilic reaction, and little evidence of widespread edema except for focal intra-alveolar hemorrhage.ConclusionsPostmortem lungs that exhibit the ELS constitute a morphologically-identifiable subgroup of ARDS cases. The ordered nature of the ELS, as indicated by both elastin and amyloid stains, together with little morphological evidence of inflammation or edema, suggests that this cohort of ARDS may represent another form of conformational disease. If this hypothesis is confirmed, it will require a new approach in the diagnosis and treatment of patients who exhibit this form of acute lung injury.

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Section: Discussionmentioning

confidence: 84%

Amyloid associated with elastin-staining laminar aggregates in the lungs of patients diagnosed with acute respiratory distress syndrome

Fan

Nagle

2002

BMC Pulm Med

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“…Lipofuscin, collagen cross‐links, tryptophan, nicotinamide adenine dinucleotide (NADH), or more generally, the presence of altered cellular or mitochondrial activity, have all been suggested as potential sources . Pingueculae autofluoresce strongly on CUVAF imaging and contain elastotic material and advanced glycation end‐products (AGEs), both of which autofluoresce in the cornea and skin . Some AGEs form by cross‐linking with proteins such as collagen or elastin and UV exposure can speed up this process …”

Section: Introductionmentioning

confidence: 99%

“…11,18,19 Pingueculae autofluoresce strongly on CUVAF imaging and contain elastotic material and advanced glycation end-products (AGEs), both of which autofluoresce in the cornea and skin. 6,18,[20][21][22][23] Some AGEs form by cross-linking with proteins such as collagen or elastin and UV exposure can speed up this process. 24 Measurement of CUVAF area in patients is a valuable tool for studying sun-exposure-related eye conditions and for identifying patients at risk of these conditions.…”

Section: Introductionmentioning

confidence: 99%

Repurposing blue laser autofluorescence to measure ocular sun exposure

Lingham

Burton

Brown

et al. 2018

Clinical Exper Ophthalmology

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Importance Excessive ocular sun exposure is linked to various eye pathologies. Conjunctival ultraviolet autofluorescence (CUVAF) is a method of detecting sun‐related conjunctival damage; however, the custom‐built camera system required is not readily available. Background We investigated whether blue laser autofluorescence (BAF) on a commonly used confocal scanning laser ophthalmoscope (cSLO) can be utilized to measure CUVAF area. Design Cross‐sectional evaluation of a diagnostic technology at a medical research institute. Participants Sixty‐four participants recruited from three on‐going observational eye studies in Western Australia. Methods All participants had four images, two of each eye, captured using the CUVAF camera and BAF on the same day. Participants with pterygium or poor quality images were excluded from the analysis. Two graders measured CUVAF area in each image twice. CUVAF area measured by BAF was then compared to measurements determined with the conventional camera system. Main Outcome Measures CUVAF area. Results After exclusions, 50 participants' images were analysed. Intra‐ and inter‐observer repeatability were similar between the two systems. When comparing CUVAF area measured by BAF to the camera measurement, grader 1 had a mean difference of +1.00 mm2, with 95% limits of agreement −5.75 to 7.77 mm2. Grader 2 had a mean difference of +0.21mm2, with 95% limits of agreement −7.22 to 7.64 mm2. Conclusions and Relevance BAF on a commercially available cSLO is a valid method for measuring CUVAF area. This finding provides broader opportunity for identifying, monitoring and educating patients with sun‐exposure‐related ocular conditions and for researching the ocular impacts of sun exposure.

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The Stromal Dystrophies

Sousa¹,

Mannis²

2011

Cornea

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Corneal elastosis within lattice dystrophy lesions.

Cited by 7 publications

References 18 publications

Amyloid associated with elastin-staining laminar aggregates in the lungs of patients diagnosed with acute respiratory distress syndrome

Amyloid associated with elastin-staining laminar aggregates in the lungs of patients diagnosed with acute respiratory distress syndrome

Repurposing blue laser autofluorescence to measure ocular sun exposure

The Stromal Dystrophies

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