Corneal Donor Characteristics and Descemet Membrane Endothelial Keratoplasty Success: A Scoping Review

Weinel, Luke; Tamme, Golding-holbrook; Chen, Jern Yee; Richard, M. C.

doi:10.1097/ico.0000000000002682

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…Also, the diabetic status and complication degree of the patient were not defined in the cited studies. As previously reported by Luke et al, the overall quality of data is low and further research on this field is warranted [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome

Schrittenlocher

Matthaei

Bachmann

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Background Posterior lamellar keratoplasty and especially Descemet membrane endothelial keratoplasty (DMEK) are gaining interest worldwide. Little is known about the influence of donor factors on DMEK outcome. Here we provide an overview of the existing peer-reviewed literature on this topic and present the design of the upcoming cooperation study COMEDOS (Cologne-Mecklenburg-Vorpommern DMEK Donor Study). Methods A literature search of PubMed and MEDLINE was conducted to retrieve articles published between September 2013 and May 2021. Seventeen peer-reviewed articles were selected. Design and concept of the prospective COMEDOS are outlined. Results Main interest parameters were the donor diabetes mellitus status, age, and lens status. There is a large heterogeneity regarding the sample size, study design, and investigated parameters. There seems to be a consensus that younger donors are associated with tighter rolls, a more difficult preparation, and unfolding setting. Diabetic donors seem to increase the risk of tissue tearing due to adherences and result more frequently in preparation failure. The COMEDOS aims not only to analyze the diabetes status of the donor, but also to correlate all donor systemic comorbidities and their ophthalmologic history to the DMEK clinical outcome. Furthermore, a correlation of Descemet membrane lamella preparation and surgery outcome is planned. Conclusion Currently, there is a lack of knowledge regarding the effect and impact of donor tissue characteristics on DMEK outcome and complications. An in-depth investigation is planned by the upcoming COMEDOS to close this knowledge gap.

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Section: Discussionmentioning

confidence: 99%

The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome

Schrittenlocher

Matthaei

Bachmann

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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“…[ 6 7 ] This results in an increased incidence of graft tearing during graft preparation and subsequent graft preparation failure. [ 8 ] However, donor diabetes status did not result in increased rebubbling rate and postoperative increased endothelial cell loss at 6 months. [ 9 ]…”

Section: Preoperative Considerations For Dmekmentioning

confidence: 99%

Descemet membrane endothelial keratoplasty: Update on preoperative considerations, surgical techniques, and outcomes

Singh¹,

Sinha²,

Nagpal

et al. 2022

Indian Journal of Ophthalmology

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Descemet membrane endothelial keratoplasty (DMEK) is the closest to the physiological replacement of endothelial cells. In the initial years, the technique was surgically challenging. Over the years, with better understanding and modifications in the surgical steps, the technique has evolved as an alternative to more popular procedure Descemet stripping endothelial keratoplasty. The article highlights the various preoperative, intraoperative, and postoperative nuances of DMEK. Additionally, it summarizes the various comparative and noncomparative studies on DMEK outcomes.

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“…e first step towards successful DMEK surgery is to master the donor tissue preparation technique [16]. Although many different techniques have been proposed for DMEK graft preparation, there is no consensus as to which is the optimum [17].…”

Section: Graft Preparationmentioning

confidence: 99%

Tips, Tricks, and Guides in Descemet Membrane Endothelial Keratoplasty Learning Curve

Borroni

Lossada

Parekh

et al. 2021

Journal of Ophthalmology

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Lamellar keratoplasty is fast becoming the most popular form of corneal transplantation. The adoption of Descemet membrane endothelial keratoplasty (DMEK) in the management of Fuchs endothelial dystrophy and pseudophakic bullous keratopathy is partly responsible for this shift in the paradigm of management of corneal pathology. The learning curve of DMEK, however, has been proven to be much steeper than previous endothelial keratoplasty procedures. To ease the procedure, experts have proposed multiple innovative techniques from tissue preparation to graft unfolding to aid the more novice surgeon. Here, we collate and share tips and tricks from our collective experiences to support the learning curve and outcomes in DMEK for both the novice and more experienced corneal transplant surgeons.

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Corneal Donor Characteristics and Descemet Membrane Endothelial Keratoplasty Success: A Scoping Review

Cited by 11 publications

References 22 publications

The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome

The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome

Descemet membrane endothelial keratoplasty: Update on preoperative considerations, surgical techniques, and outcomes

Tips, Tricks, and Guides in Descemet Membrane Endothelial Keratoplasty Learning Curve

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