Corneal cut closure using temperature-controlled CO2 laser soldering system

Tal, Kfir; Strassmann, Eyal; Loya, Nino; Ravid, Avi; Kariv, Naam; Weinberger, Dov; Katzir, Abraham; Gaton, Dan D.

doi:10.1007/s10103-015-1737-2

Cited by 13 publications

(5 citation statements)

References 30 publications

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“…Recently, the effective application of temperature control and radiometry during laser soldering to treat corneal cuts has been reported [132,133]. For example, Tal et al demonstrated the application of a temperature-controlled CO 2 laser soldering system (power density of 16 W/cm 2 ; 65°C) using a BSA-based solder (47%) for corneal cut closure [132]. The authors used pigs as the animal model and demonstrated that the soldered corneas had milder stromal inflammation, less neovascularization, and a higher level of re-epithelization than sutured controls.…”

Section: Serum Albumin-based Adhesivementioning

confidence: 99%

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary neovascularization, erosion to the surface and secondary infection, and astigmatism; for example, more than half of post-corneal transplant infections are due to suture related complications. Tissue adhesives provide promising substitutes for sutures in ophthalmic surgery. Ocular adhesives are not only intended to address the shortcomings of sutures, but also designed to be easy to use, and can potentially minimize post-operative complications. Herein, recent progress in the design, synthesis, and application of ocular adhesives, along with their advantages, limitations, and potential are discussed. This review covers two main classes of ocular adhesives: (1) synthetic adhesives based on cyanoacrylates, polyethylene glycol (PEG), and other synthetic polymers, and (2) adhesives based on naturally derived polymers, such as proteins and polysaccharides. In addition, different technologies to cover and protect ocular wounds such as contact bandage lenses, contact lenses coupled with novel technologies, and decellularized corneas are discussed. Continued advances in this area can help improve both patient satisfaction and clinical outcomes.

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Section: Serum Albumin-based Adhesivementioning

confidence: 99%

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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“…Corneal inflammation remains a major and common clinical problem underlying many disease processes, such as: severe dry eye, infectious keratitis, chemical burn related injuries, corneal graft rejection and others [1–6]. If left untreated at its initial stages, corneal inflammation often progresses to a chronic stage and this persistent infiltration of the cornea by white blood cells and macrophages may lead to neovascularization, corneal opacity, edema, and vision loss [7,8].…”

Section: Introductionmentioning

confidence: 99%

Subconjunctival injectable dendrimer-dexamethasone gel for the treatment of corneal inflammation

et al. 2017

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Corneal inflammation is often encountered as a key pathological event in many corneal diseases. Current treatments involve topical corticosteroids which require frequent instillations due to rapid tear turnover, causing side-effects such as corneal toxicity and elevated intraocular pressure (IOP). Hence, new interventions that can reduce side effects, dosing frequency, and increase patient compliance can be highly beneficial. In this study, we explore a subconjunctival injectable gel based on G4-PAMAM dendrimer and hyaluronic acid, cross-linked using thiol-ene click chemistry, incorporated with dendrimer dexamethasone (D-Dex) conjugates as a potential strategy for sustained delivery and enhanced bioavailability of corticosteroids. The efficacy of the injectable gel formulation was evaluated in a rat mild alkali burn model. Fluorescently-labelled dendrimers (D-Cy5) incorporated in the gel release D-Cy5 in vivo. The released D-Cy5 selectively targets and localizes within corneal macrophages in inflamed rat cornea but not in healthy controls. This pathology dependent biodistribution was exploited for drug delivery, by incorporating D-Dex in the injectable gel. The attenuation of corneal inflammation by D-Dex gels was assessed using various clinical and biochemical parameters over a 2-week period. Subconjunctival D-Dex gel treatment resulted in favorable clinically-relevant outcomes with reduced central corneal thickness and improved corneal clarity compared to free-Dex and placebo gel controls. The extent of corneal neovascularization was significantly reduced in the D-Dex group. These findings suggest that D-Dex attenuates corneal inflammation more effectively than free-Dex by attenuating macrophage infiltration and pro-inflammatory cytokines expression. A significant elevation in IOP was not observed in the D-Dex group but was observed in the free-Dex group. This novel injectable D-Dex gel may be a potential drug delivery platform for the treatment of many inflammatory ocular surface disorders such as dry eye, autoimmune keratitis and post-surnical complications where frequent steroid administration is required.

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“…[67] Others have developed elegant infraredbased CO 2 lasers for tissue soldering. [68][69][70] Combining tissue soldering technology with CaproGlu may open more avenues of application for tissue fixation.…”

Section: Discussionmentioning

confidence: 99%

Tougher Bioadhesives through Dual Stimulation Strategies

Ang,

Djordjevic,

Solic

et al. 2024

Adv Healthcare Materials

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Carbene based bioadhesives have favourable attributes for tissue adhesion, including non‐specific bonding to wet and dry tissues, but suffer from relatively weak fracture strength after photocuring. Light irradiation of carbene‐precursor (diazirine) also creates inert side products that are absent under thermal activation. Herein, a dual activation method combines light irradiation at elevated temperatures for the evaluation of diazirine depletion and effects on cohesive properties. A customized photo/thermal‐rheometer evaluates viscoelastic properties, correlated to the kinetics of carbene:diazoalkane ratios via 19F NMR. The latter exploits the sensitive ‐CF3 functional group to determine joule‐based light/temperature kinetics on trifluoroaryl diazirine consumption. The combination of heat and photoactivation produced bioadhesives that are 3x tougher compared to control. Dual thermal/light irradiation may be a strategy to improve viscoelastic dissipation and toughness of photo‐activated adhesive resins.This article is protected by copyright. All rights reserved

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Corneal cut closure using temperature-controlled CO2 laser soldering system

Cited by 13 publications

References 30 publications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Subconjunctival injectable dendrimer-dexamethasone gel for the treatment of corneal inflammation

Tougher Bioadhesives through Dual Stimulation Strategies

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