Corneal cross‐linking as a treatment for corneal dystrophy with secondary bacterial infection in a Friesian horse

Casola, Christina; Pot, Simon A.; Lavaud, Arnold; Voelter, Katrin

doi:10.1002/ccr3.2725

Cited by 3 publications

(4 citation statements)

References 61 publications

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“…The term corneal dystrophy is used for bilateral corneal stromal loss in the Friesian horse, and this is a genetic, bilateral disease with well-defined circular defects usually in the infero-temporal quadrant of the cornea, which can progress to a descemetocele and can need surgical intervention. 1,6,7 In birds, crystalline corneal degeneration has been described, but there are no available data on corneal dystrophy. 18 Webb et al described the disease in Canadian alpacas.…”

Section: Discussionmentioning

confidence: 99%

“…Horses seem to be affected only rarely, and abnormal deposition of abnormal material in the equine cornea is not described as corneal dystrophy. The term corneal dystrophy is used for bilateral corneal stromal loss in the Friesian horse, and this is a genetic, bilateral disease with well‐defined circular defects usually in the infero‐temporal quadrant of the cornea, which can progress to a descemetocele and can need surgical intervention 1,6,7 …”

Section: Discussionmentioning

confidence: 99%

“…The term corneal dystrophy is also used for Friesian horse's bilateral corneal stromal loss, but this term is used with this meaning only in this specific case. 1,6,7 The disease has also been described in rats and, to a lesser extent, in mice. In these species, it is more frequent and severe with increasing age, and it has not been associated with systemic disease.…”

Section: Introductionmentioning

confidence: 97%

“…It consists of loss of transparency due to deposition of abnormal material and is classified according to the location of the deposits. The term corneal dystrophy is also used for Friesian horse's bilateral corneal stromal loss, but this term is used with this meaning only in this specific case 1,6,7 …”

Section: Introductionmentioning

confidence: 99%

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A bilateral corneal descemetocele as a consequence of corneal dystrophy in a ferret (Mustela putorius furo)

Cattaneo,

Bersanetti,

Guandalini

2024

Vet Record Case Reports

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The purpose was to describe the clinical findings, surgery and outcome of a bilateral descemetocele in a ferret (Mustela putorius furo), resulting from corneal dystrophy. A female ferret was diagnosed with a descemetocele in the left eye, as a result of corneal dystrophy with crystalline deposits, which spontaneously detached. Surgery was performed with a corneal graft and a conjunctival flap. No systemic disease was correlated with the corneal dystrophy. After 3 months, the ferret was presented with a descemetocele of the right eye, still due to corneal dystrophy. The same surgery as previously described was performed. The ferret recovered uneventfully from both surgeries and maintained vision from both eyes. This is the first report of corneal dystrophy in a ferret, and the first report of successful surgery on a descemetocele in this species. Surgery is the treatment of choice, and if performed quickly and adequately, has a good outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A bilateral corneal descemetocele as a consequence of corneal dystrophy in a ferret (Mustela putorius furo)

Cattaneo,

Bersanetti,

Guandalini

2024

Vet Record Case Reports

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Advanced Ophthalmic Imaging in the Horse

Ledbetter¹,

Porter²

2022

Equine Ophthalmology

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Analysis of Pathogenic Bacteria of Mooren’s Ulcer and T Lymphocyte Activation

Zhao

Zhang

Jin

et al. 2022

j biomater tissue eng

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To analyze the distribution and types of pathogenic bacteria of Mooren’s ulcer and the activation mechanism of T lymphocytes to provide reference for the treatment of Mooren’s ulcer, 156 patients (162 eyes) who were in the hospital were rolled into the observation group. During the same period, 134 healthy people were rolled into the control group. The distribution of infectious pathogens in the observation group was identified. Then, flow cytometry was adopted to separate and detect the peripheral blood lymphocytes of patients, and RT-PCR was used to detect levels of the transcription factor T-bet, GATA-3, and Stat5 in peripheral blood mononuclear cells (PBMCs). It was found that fungal pathogens accounted for 43.59%; the bacterial infection rate was 40.38%. In the observation group, the CD4, CD8, and C25 were expressed more (P < 0.01), and the CD45 and CD45R were expressed less than the control group (P < 0.05); the proportion of Th1 cells was obviously higher (P < 0.01); the expression of T-bet and GATA-3 was obviously higher (P < 0.05), the percentage of HLA-DR in CD4+ and HLA-DR, CD-25, and CD69 in CD8+ positive cells was obviously higher (P < 0.05). In conclusion, fungal infection rate of Mooren’s ulcer is relatively high, peripheral blood T cells and their subgroups are abnormally activated, and T cell activation is related to the pathogenesis of Mooren’s ulcer.

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Corneal cross‐linking as a treatment for corneal dystrophy with secondary bacterial infection in a Friesian horse

Abstract: Corneal cross‐linking should be considered as treatment option in Friesian horses with infectious keratitis and corneal dystrophy. Optical coherence tomography, giving information of corneal structure, can help for diagnosis and monitoring.

Cited by 3 publications

References 61 publications

A bilateral corneal descemetocele as a consequence of corneal dystrophy in a ferret (Mustela putorius furo)

A bilateral corneal descemetocele as a consequence of corneal dystrophy in a ferret (Mustela putorius furo)

Advanced Ophthalmic Imaging in the Horse

Analysis of Pathogenic Bacteria of Mooren’s Ulcer and T Lymphocyte Activation

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