Corneal confocal microscopy in a healthy Brazilian sample

Dieckmann, G; Pupe, Camila; Nascimento, Osvaldo J. M.

doi:10.1590/0004-282x20150178

Cited by 7 publications

(6 citation statements)

References 18 publications

(14 reference statements)

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“…The sample size was calculated based on published reports of subbasal nerve analyses for other ethnicities, and at least 76 eyes were requisite for a valid analysis. [25][26][27]…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Corneal Subbasal Nerves in Different Age Groups: An in vivo Confocal Microscopic Analysis

Chirapapaisan¹,

Thongsuwan²,

Chirapapaisan³

et al. 2021

OPTH

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Purpose: To determine the normative characteristics of corneal subbasal nerves in different age groups using laser scanning in vivo confocal microscopy (IVCM). Patients and Methods: This descriptive observational study recruited healthy subjects (aged 20-60 years) from Siriraj Health-Screening Center. Excluded were individuals who had abnormal ocular symptoms, previous ocular surgery, a history of any diseases related to systemic and/or corneal neuropathy, or abnormal corneal sensitivity. Corneal IVCM (HRT3/ Rostock Corneal Module) was performed at the central cornea to analyze the subbasal nerve plexus. The corneal nerve characteristics, comprising the number and density of nerves (main nerve trunks, branches, and total nerves) were analyzed using the NeuronJ program, and the corneal nerve tortuosity was graded. The correlations between the subbasal nerve density, tortuosity and age were then analyzed. Results: Eighty subjects were enrolled, with twenty in each of four age groups (20-30, >30-40, >40-50, and >50-60 years). Overall, the mean number and density of main nerve trunks were 27.93±0.81/mm 2 and 11.22±0.30 mm/mm 2 , respectively. As of the nerve branches, the average number and density were 103.56±2.37/mm 2 and 9.15±0.30 mm/mm 2 , respectively. The total nerve density was 20.37±0.39 mm/mm 2 . There were no significant differences between subbasal nerve parameters of the four age groups. It is noteworthy that 65% of the subjects aged over 40 years revealed high-grade nerve tortuosity. Conclusion:The corneal subbasal nerve numbers and densities were not significantly different among a healthy population aged 20-60 years. However, there was a trend towards high tortuosity of the corneal nerve in people aged over 40 years.

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“…The sample size was calculated based on published reports of subbasal nerve analyses for other ethnicities, and at least 76 eyes were requisite for a valid analysis. [25][26][27]…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Corneal Subbasal Nerves in Different Age Groups: An in vivo Confocal Microscopic Analysis

Chirapapaisan¹,

Thongsuwan²,

Chirapapaisan³

et al. 2021

OPTH

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“…In the present study, we compared the morphological changes in the sub-basal corneal epithelial plexus through in vivo CCM (IVCCM) in 35 diabetic patients with symptomatic DSP to 55 control subjects in a Brazilian sample taken from a previous study. 7 In addition, we sought to determine a pattern of change regarding the stages of severity of the DSP, comparing clinical, laboratory, and NCS variables.…”

Section: Introductionmentioning

confidence: 99%

Corneal confocal microscopy in patients with distal symmetric polyneuropathy compared to controls

et al. 2022

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Background Diabetic neuropathy (DN) is a very common clinical condition throughout the world. The diagnostic tests currently recommended have low sensitivity, such as electromyography, or are invasive, such as skin biopsy. New techniques have been developed to identify the early involvement of the peripheral nerve. With the advent of corneal confocal microscopy (CCM), a reduction in corneal innervation in patients with DN has been observed. Objective To compare, through CCM, diabetic patients with symptomatic distal symmetric polyneuropathy (DSP) and controls. Methods In the present study, through CCM, we compared the morphological changes in the sub-basal epithelial corneal plexus of 35 diabetic patients with symptomatic DSP with 55 controls. Moreover, we sought to determine a pattern of change regarding the severity stages of DSP, comparing the clinical, laboratory, and nerve-conduction (NC) variables. Results Differences between the control and diabetic groups were observed for the following variables, respectively: age (44.9 ± 13.24 years versus 57.02 ± 10.4 years; p < 0.001); fiber density (29.7 ± 10.2 versus 16.6 ± 10.2; p < 0.001); number of fibers (4.76 ± 1.30 versus 3.14 ± 1.63; p < 0.001); number of Langerhans cells (4.64 ± 8.05 versus 7.49 ± 10.3; p = 0.035); tortuosity (p < 0.05); and thickness (p < 0.05). Furthermore, inverse relationships were found regarding fiber density and age (p < 0.01) and fiber density and the severity of the disease (p < 0.05). A positive relationship between the conduction velocity of the fibular nerve and fiber density (p < 0.05) was also observed. Conclusion Corneal confocal microscopy proved to be a fast, noninvasive and reproducible method for the diagnosis, staging, and monitoring of diabetic DSP.

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“…In patients with diabetes mellitus, several parameters of corneal confocal microscopy correlate with intra-epidermal nerve fiber density 65 . Very recently, normative data for corneal confocal microscopy from Brazil (Federal Fluminense University, Rio de Janeiro) have been reported 66 .…”

Section: In Vivo Confocal Microscopymentioning

confidence: 99%

Definition and diagnosis of small fiber neuropathy: consensus from the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology

Gondim

Barreira

Claudino

et al. 2018

Arq. Neuro-Psiquiatr.

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The aim of this study was to describe the results of a Brazilian Consensus on Small Fiber Neuropathy (SFN). Fifteen neurologists (members of the Brazilian Academy of Neurology) reviewed a preliminary draft. Eleven panelists got together in the city of Fortaleza to discuss and finish the text for the manuscript submission. Small fiber neuropathy can be defined as a subtype of neuropathy characterized by selective involvement of unmyelinated or thinly myelinated sensory fibers. Its clinical picture includes both negative and positive manifestations: sensory (pain/dysesthesias/pruritus) or combined sensory and autonomic complaints, associated with an almost entirely normal neurological examination. Standard electromyography is normal. A growing list of medical conditions is associated with SFN. The classification of SFN may also serve as a useful terminology to uncover minor discrepancies in the normal values from different neurophysiology laboratories. Several techniques may disclose sensory and/or autonomic impairment. Further studies are necessary to refine these techniques and develop specific therapies.

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Corneal confocal microscopy in a healthy Brazilian sample

Cited by 7 publications

References 18 publications

Characteristics of Corneal Subbasal Nerves in Different Age Groups: An in vivo Confocal Microscopic Analysis

Characteristics of Corneal Subbasal Nerves in Different Age Groups: An in vivo Confocal Microscopic Analysis

Corneal confocal microscopy in patients with distal symmetric polyneuropathy compared to controls

Definition and diagnosis of small fiber neuropathy: consensus from the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology

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