Corneal collagen crosslinking in post-LASIK keratectasia

Salgado, J.P.; Khoramnia, Ramin; Lohmann, Chris P.; Mohrenfels, C. Winkler von

doi:10.1136/bjo.2010.179424

Cited by 77 publications

(43 citation statements)

References 25 publications

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“…] orneal cross-linking (CXL) with riboflavin and ultraviolet-A is a technique to treat keratoconus in children, adolescents, and adults, [1][2][3][4] as well as postoperative ectasia. [5][6][7][8] In clinical use since 1999, CXL increases corneal biomechanics by more than 300% in the human cornea 3,9,10 and halts progression of ectasia. Current limitations of the technique include reduced efficacy in extremely thin corneas and during pregnancy.…”

Section: Aq1resultsmentioning

confidence: 99%

Determination of the Excimer Laser Ablation Rate in Previously Cross-linked Corneas

Richoz¹,

Arba-Mosquera²,

Kling³

et al. 2014

J Refract Surg

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Section: Aq1resultsmentioning

confidence: 99%

Determination of the Excimer Laser Ablation Rate in Previously Cross-linked Corneas

Richoz¹,

Arba-Mosquera²,

Kling³

et al. 2014

J Refract Surg

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“…All authors reported stabilization or flattening of corneal keratometry and stabilization or improvement of visual acuity after standard epi-off procedure. Long-term comparative analysis showed that functional results after CXL among pediatric and young patients (up to 26 years) were better than in patients over 27 years [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] .…”

Section: Standard Procedures and Clinical Resultsmentioning

confidence: 99%

Corneal Collagen Crosslinking with Riboflavin and Ultraviolet - A Irradiation in the Management of Progressive Ectatic Corneal Disorders. Review Article

Eldine

2017

Journal of Ophthalmology and Related Sciences

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Corneal crosslinking (CXL) has been proposed as a new modality to stop progression of keratoconus or secondary corneal ectasia, aiming to prevent progressive visual loss and to delay or avoid corneal transplantation. The possibility of strengthening corneal tissue by means of a photochemical reaction of corneal collagen by the combined action of riboflavin and ultraviolet-A irradiation (UVA), radically modified the conservative management of progressive corneal ectasia. This is a review of the state of the art of CXL. The paper describes basic principles, advantages and limitations of different CXL techniques and possible future evolution of the procedure.

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“…It works as a photosensitizer for the induction of cross-links and protects the underlying tissues from the deleterious influence of UVA irradiation. CXL is currently used to treat progressive corneal ectasia occurring in keratoconus (1)(2)(3) or following laser refracti- ve surgery (4,5) . It is thought to work by enhancing the biomechanical properties of the tissue (1,2) and its resistance to enzymatic digestion (6) .…”

Section: Introductionmentioning

confidence: 99%

Corneal thickness changes during corneal collagen cross-linking with UV-A irradiation and hypo-osmolar riboflavin in thin corneas

Nassaralla¹,

Vieira

Machado

et al. 2013

Arq. Bras. Oftalmol.

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Purpose: To evaluate the thinnest corneal thickness changes during and after corneal collagen cross-linking treatment with ultraviolet-A irradiation, using hypo-osmolar riboflavin solution in thin corneas. Methods: Eighteen eyes of 18 patients were included in this study. After epithelium removal, iso-osmolar 0.1% riboflavin solution was instilled to the cornea every 3 minutes for 30 minutes. Hypo-osmolar 0.1% riboflavin solution was then applied every 20 seconds for 5 minutes or until the thinnest corneal thickness reached 400 µm. Ultraviolet-A irradiation was performed for 30 minutes. During irradiation, iso-osmolar 0.1% riboflavin drops were applied every 5 minutes. Ultrasound pachymetry was performed at approximately the thinnest point of the cornea preoperatively, after epithelial removal, after iso-osmolar riboflavin instillation, after hypo-osmolar riboflavin instillation, after ultraviolet-A irradiation, and at 1, 6 and 12 months after treatment. Results: Mean preoperative thinnest corneal thickness was 380 ± 11 µm. After epithelial removal it decreased to 341 ± 11 µm, and after 30 minutes of iso-osmolar 0.1% riboflavin drops, to 330 ± 7.6 µm. After hypo-osmolar 0.1% riboflavin drops, mean thinnest corneal thickness increased to 418 ± 11 µm. After UVA irradiation, it was 384 ± 10 µm. At 1, 6 and 12 months after treatment, it was 372 ± 10 µm, 381 ± 12.7, and 379 ± 15 µm, respectively. No intraoperative, early postoperative, or late postoperative complications were noted. Conclusions: Hypo-osmolar 0.1% riboflavin solution seems to be effective for swelling thin corneas. The swelling effect is transient and short acting. Corneal thickness should be monitored throughout the procedure. Larger sample sizes and longer follow-up are required in order to make meaningful conclusions regarding safety.

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Corneal collagen crosslinking in post-LASIK keratectasia

Abstract: Abstract:Background/Aims: To evaluate the effect of corneal collagen crosslinking with

Cited by 77 publications

References 25 publications

Determination of the Excimer Laser Ablation Rate in Previously Cross-linked Corneas

Determination of the Excimer Laser Ablation Rate in Previously Cross-linked Corneas

Corneal Collagen Crosslinking with Riboflavin and Ultraviolet - A Irradiation in the Management of Progressive Ectatic Corneal Disorders. Review Article

Corneal thickness changes during corneal collagen cross-linking with UV-A irradiation and hypo-osmolar riboflavin in thin corneas

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