Corneal Blood Staining Following Autologous Blood Injection for Hypotony Maculopathy

Ayyala, Ramesh S.; Urban, Robert C.; Krishnamurthy, Mina S; Mendelblatt, David

doi:10.3928/1542-8877-19971001-11

Cited by 7 publications

(1 citation statement)

References 5 publications

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“…Nonsurgical methods of bleb revision include injection of autologous blood serum to stimulate scarring and thereby reduce bleb height, but studies have reported variable results [15][16][17][18][19][20] and complications, including bleb failure, have been reported with this technique. [21][22][23][24] Laser treatments have been used but may require multiple sessions that can induce inflammation and ultimately lead to less predictable IOP control. 1 The application of trichloroacetic acid 25,26 and cryotherapy 27,28 have also been described but are rarely effective, particularly when antimetabolites have been used.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of bleb revision with ologen following filtering glaucoma surgery

Kornmann

Fellman

Smith

et al. 2021

European Journal of Ophthalmology

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Purpose This study reports long-term outcomes of bleb revision with ologen™ Collagen Matrix (Aeon Astron Europe BV, the Netherlands) for the surgical management of various bleb-related issues including persistent bleb leaks with or without associated hypotony, bleb dysesthesia, overhanging blebs, or hypotony after filtering glaucoma surgery. Materials and methods A retrospective chart review was performed for patients who underwent ologen bleb revision from 2012 to 2019 at Glaucoma Associates of Texas. Results The study included 23 eyes of 22 patients undergoing bleb revision with the ologen implant. Mean age was 74.0 ± 11.3 years, 16 (69.6%) were female, and 13 (56.5%) were White. Indications for bleb revision included bleb leak (78.3%), dysesthesia (13.0%), and hypotony from an overfiltering bleb (8.7%). Mean preoperative intraocular pressure was 6.8 ± 4.1 mmHg and the number of medications was 0.3 ± 0.9. Median follow-up was 24 months (range: 12–84 months); all patients had at least 12 months of follow-up. At 1 year, mean intraocular pressure was 10.9 ± 4.6 mmHg on 0.2 ± 0.5 medications, and at last follow-up, mean intraocular pressure was 10.4 ± 3.6 mmHg on 0.3 ± 0.7 medications. Bleb morphology remained low, diffuse, and posterior. One patient developed kissing choroidal effusions requiring surgical drainage with subsequent stabilization of intraocular pressure and bleb function, and three patients required additional surgery due to persistent leaks or bleb failure; there were no other vision-threatening complications. Conclusions Use of the ologen implant during surgical bleb revision is a useful surgical technique that confers long-term improvements in bleb morphology and stability of function.

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Section: Discussionmentioning

confidence: 99%

Outcomes of bleb revision with ologen following filtering glaucoma surgery

Kornmann

Fellman

Smith

et al. 2021

European Journal of Ophthalmology

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Effect of Phacoemulsification Surgery on Hypotony Following Trabeculectomy Surgery

Doyle¹

2000

Arch Ophthalmol

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To review the effect of phacoemulsification surgery in eyes with chronic hypotony following trabeculectomy with mitomycin C. Design: Retrospective analysis of all eyes that underwent phacoemulsification surgery for symptomatic cataracts and had a preoperative diagnosis of chronic hypotony (intraocular pressure [IOP] Յ6 mm Hg) for at least 6 months following trabeculectomy with mitomycin C. Each case had at least 6 months' follow-up after the phacoemulsification surgery. Setting: A tertiary care referral center. Intervention: Clear cornea phacoemulsification surgery, with minimal perioperative anti-inflammatory medication and retention of viscoelastic in eyes at case conclusion. Main Outcome Measures: Intraocular pressure, visual acuity, and complications. Results: Nine eyes of 9 patients were identified. Mean preoperative IOP was 4.2 ± 1.4 mm Hg; the mean postoperative IOP was 7.3 ± 2.8 mm Hg (P=.009). Intraocular pressure increased in all but 2 eyes. One of these 2 eyes experienced an acutely elevated IOP (34 mm Hg) on postoperative day 4, which dropped back to preoperative levels after trabeculectomy flap needling. Mean preoperative visual acuity was 20/300; mean postoperative visual acuity was 20/40. Conclusion: Phacoemulsification surgery may be associated with a statistically significant elevation in IOP in previously filtered eyes with hypotony, resulting in resolution of hypotony in some of these challenging cases.

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