Corneal Argon Laser Photocoagulation for Neovascularization in Penetrating Keratoplasty

Nirankari, Verinder S.; Baer, John C.

doi:10.1016/s0161-6420(86)33581-4

Cited by 50 publications

(30 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, if the vessels have been established for an extended period, these treatments are ineffective (Epstein et al 1987). Although, argon laser NV has been reported, this method achieved an inadequate effect because of the high incidence of recanalization and thermal damage to the adjacent tissues (Nirankari and Bear 1986;Marsh 1988).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Abdelkawi

Hassan²

2012

gpb

View full text Add to dashboard Cite

Abstract. The aim of the present study was to evaluate the change in corneal protein and oxidative stress state after using photodynamic therapy (PDT) for treatment of experimental corneal neovascularization (NV) with benzoporphyrin derivative (BPD). One group was considered as control (N = 10 eyes), corneal NV was induced in 25 New Zealand male rabbits (N = 50 eyes) after placing silk sutures in the corneal limbus. Five rabbits with corneal NV were left without any treatment, and 20 rabbits were administered by intravenous injection with Verteporfin at a dose of 1.5 mg/kg. Diode laser (660 nm) was applied for 5 minutes with a power of 50 mW/cm 2 . For a period of 4 weeks, five rabbits were selected and sacrificed weekly (N = 10 eyes each). The corneas were isolated for determination of protein content, SDS-PAGE, total antioxidant capacity (TAC), total oxidative capacity (TOC), malondialdhyde (MDA) and oxidative stress index (OSI). The results indicated that corneal NV induced changes in the content and composition on the corneal protein and gradual improvement of the cornea after the 3 rd and 4 th week of PDT was detected. Furthermore, the oxidative/antioxidative balance shifted towards the antioxidative status that helped to prevent further damage.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Abdelkawi

Hassan²

2012

gpb

View full text Add to dashboard Cite

show abstract

“…[24] Thermal coagulation and occlusion of vessels can also be done using laser beams. [25][26][27][28][29][30][31][32][33] Cherry and Garner used [28] corneal argon laser photocoagulation (CALP) on 4 patients for treatment of chemical burn (n=2) and herpetic keratitis (n=2), and reported 2 failures, 1 partial success, and 1 complete success. In another study, Marsh et al followed 41 patients who had undergone CALP for lipid keratopathy, and after 9 months they found decrease in corneal opacity in 28 patients, and increase or stabilization in visual acuity in 33.…”

Section: Discussionmentioning

confidence: 99%

“…[29,30] Nirankari and Baer reported successful outcomes in patients who had undergone CALP procedure for deep corneal neovascularization. [31] Baer et al [26] used 577 nm yellow dye laser and reported reversal of graft rejection in 25 eyes of 23 patients and 68% decrease in corneal neovascularization. The authors did not, however, find CALP procedure effective in cases with diffuse corneal neovascularization.…”

Section: Discussionmentioning

confidence: 99%

“…[5,6] As has been demonstrated in many studies, treatment of neovascularization before corneal transplantation prolongs graft life. [7] Many agents and methods such as steroids, radiation, cystine, cryotherapy, and dextran have been used to occlude corneal vessels. [8][9][10][11] Ophthalmologists have also used argon laser [12][13][14][15][16][17] and 577-nm yellow dye laser [18,19] to occlude corneal vessels and have reported successful outcomes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fine Needle Diathermy for Corneal Neovascularization: Initial Results

Şalkacı¹,

Çallı²,

Kandemir³

et al. 2017

South Clin Ist Euras

View full text Add to dashboard Cite

Objective: The present study is a report of first results of fine needle diathermy (FND) procedure, the method of treatment preferred in our clinic for patients with corneal neovascularization.Methods: FND was performed on 34 eyes with corneal neovascularization in 34 patients. Anterior segment color photos were taken of all patients before and after the procedure. Visual acuity and vascularization size and depth before and after procedure were compared. Number of procedures and complications were noted.Results: Causes of vascularization were lipid keratopathy with unknown primary pathology in 12 patients, herpetic keratitis in 9, bacterial keratitis in 6, corneal graft rejection in 3, fungal keratitis in 2, alkaline burn in 2, and trauma in 1 patient. All vessels were successfully occluded in 15 patients. In 7 patients, 75% of treated vessels were occluded, and 50% of treated vessels were occluded in 5 patients. FND was performed twice on 12 patients and 3 times on 4 patients. In some cases, additional procedures were successful, and in others it was determined to be insufficient. Conclusion:FND is a safe and effective treatment for corneal neovascularization in some patients; however, in some cases, the procedure is only partially effective.

show abstract

“…The patients in the study suffered from corneal NV related to transplant rejection that was unresponsive to steroid treatment. 44,49 Photodynamic therapy, a similar process, uses a laser to activate a photosensitizing compound that is preferentially targeted to the neovasculature. The activated compound generates free radicals, which are cytotoxic to vascular endothelial cells, thereby destroying blood vessels.…”

Section: Non-vegf Treatmentsmentioning

confidence: 99%

Nanotechnology in Corneal Neovascularization Therapy—A Review

Gonzalez

Loza

Han

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

View full text Add to dashboard Cite

Nanotechnology is an up-and-coming branch of science that studies and designs materials with at least one dimension sized from 1-100 nm. These nanomaterials have unique functions at the cellular, atomic, and molecular levels.1 The term ''nanotechnology'' was first coined in 1974. 2 Since then, it has evolved dramatically and now consists of distinct and independent scientific fields. Nanotechnology is a highly studied topic of interest, as nanoparticles can be applied to various fields ranging from medicine and pharmacology, to chemistry and agriculture, to environmental science and consumer goods. 3 The rapidly evolving field of nanomedicine incorporates nanotechnology with medical applications, seeking to give rise to new diagnostic means, treatments, and tools. Over the past two decades, numerous studies that underscore the successful fusion of nanotechnology with novel medical applications have emerged. This has given rise to promising new therapies for a variety of diseases, especially cancer. It is becoming abundantly clear that nanotechnology has found a place in the medical field by providing new and more efficient ways to deliver treatment. Ophthalmology can also stand to benefit significantly from the advances in nanotechnology research. As it relates to the eye, research in the nanomedicine field has been particularly focused on developing various treatments to prevent and/or reduce corneal neovascularization among other ophthalmologic disorders. This review article aims to provide an overview of corneal neovascularization, currently available treatments, and where nanotechnology comes into play.

show abstract

Corneal Argon Laser Photocoagulation for Neovascularization in Penetrating Keratoplasty

Cited by 50 publications

References 5 publications

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Fine Needle Diathermy for Corneal Neovascularization: Initial Results

Nanotechnology in Corneal Neovascularization Therapy—A Review

Contact Info

Product

Resources

About

Corneal Argon Laser Photocoagulation for Neovascularization in Penetrating Keratoplasty

Cited by 50 publications

References 5 publications

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Fine Needle Diathermy for Corneal Neovascularization: Initial Results

Nanotechnology in Corneal Neovascularization Therapy—A Review

Contact Info

Product

Resources

About

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization

Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization