Corneal and Retinal Complications after Cataract Extraction

Binkhorst, C.D.

doi:10.1016/s0161-6420(80)35183-x

Cited by 85 publications

(24 citation statements)

References 16 publications

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“…We attribute the slightly higher risk of aphakic/pseudophakic RD since 1983 in our study to increasing availability and use of the Nd-YAG laser. 19771978197919801981Year 198319841986 This figure is broadly similar to those of other studies,235 and some of the differences may be attributable to the varying prevalence of aphakia, and possibly myopia, in the populations studied. Between 1982 and 1983 almost all cataract surgeons in this State changed to extracapsular surgery, and a statistically significant fall in aphakic and pseudophakic RDs followed this change.…”

Section: Discussionsupporting

confidence: 86%

Retinal detachment and its relation to cataract surgery.

Gray

Evans

Constable

et al. 1989

British Journal of Ophthalmology

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With the advent of microsurgical techniques and the introduction of extracapsular surgery postoperative complications such as RD may have declined, though it is well recognised that surgical or YAG laser posterior capsulotomy increases the risk.9-" This study was undertaken to determine what effect the changing pattern of cataract surgery in Western Australia (WA) has had on the overall incidence of RD in this State.The remote WA population provided a good model for this study because all rhegmatogenous RDs within the State were referred to a small number of surgeons (and hospitals) in Perth and Bunbury, and their records were traceable. By excluding outof-State referrals we believe that the figures are accurate for the resident WA population over the period studied. Material and methodsAvailable data on all patients undergoing surgery for primary RD

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Section: Discussionsupporting

confidence: 86%

Retinal detachment and its relation to cataract surgery.

Gray

Evans

Constable

et al. 1989

British Journal of Ophthalmology

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“…4,9,12 Disagreement on the ideal intervention for pseudophakic RD is not uncommon, especially in cases which lie in the simple-to-complex range. 4,[15][16][17] During cataract surgery, traumatization of the vitreous body, 18 lower concentrations of hyaluronic acid, 19 and liquefaction of the vitreal gel phase, 18 may heighten vitreoretinal traction, thereby leading to RD in an eye that already manifests peripheral degeneration of the retina. Vitrectomy is the logical treatment for this condition, since although scleral buckling would reduce traction, it would not prevent the vitreous body from undergoing further deleterious changes.…”

Section: Discussionmentioning

confidence: 99%

Primary retinal reattachment surgery: anatomical and functional outcome in phakic and pseudophakic eyes

Halberstadt

Chatterjee-Sanz

Brandenberg

et al. 2004

Eye

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Aim To compare the anatomical and functional success of primary scleral buckling, performed either alone or in combination with vitrectomy, for primary retinal detachment (RD) in phakic eyes and in eyes had undergone uneventful phacoemulsification and had received posterior chamber lens implantations. Methods A total of 243 consecutive patients were included in this retrospective, nonrandomized comparative study. In all, 165 phakic and 78 pseudophakic individuals with primary RD underwent scleral buckling alone or in combination with vitrectomy and were followed up for 6 months. Pre-, intra-and postoperative findings including anatomical success, best-corrected visual acuity (BCVA), complications, and the development of proliferative vitreoretinopathy (PVR), macular pucker, or secondary cataracts were recorded. Cases requiring more than one surgical intervention were defined having failed, although further surgical intervention might have led to success. Results At 6 months after scleral buckling alone, the anatomical success was similar in phakic (88.98%) and pseudophakic (87.65%) eyes (log rank ¼ 0.310). The corresponding results after scleral buckling with vitrectomy were 82.13 and 77.63% for phakic and pseudophakic eyes, respectively (log rank ¼ 0.799). At 6 months after scleral buckling alone, BCVA was similar in phakic and pseudophakic eyes (0.6270.30 vs 0.7070.29; P ¼ 0.227). Likewise, after scleral buckling with vitrectomy, BCVA did not differ significantly (P ¼ 0.322) between phakic (0.3470.32) and pseudophakic eyes (0.5070.27). Conclusion The anatomical and functional outcome of primary retinal reattachment surgery, involving scleral buckling alone or in combination with vitrectomy, is similar in phakic and pseudophakic eyes.

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“…Although cataract extractions previously involved removal of the entire lens, it is more common today to leave the posterior lens capsule intact, in order to reduce postoperative complications such as vitreous changes and retinal detachment [24]. To study elimination in an aphakic eye, the human phakic eye model was modified so that the curved barrier formed by the lens (Figure 1) was replaced by the posterior capsule of the lens ( Figure 2).…”

Section: Aphakic Versus Phakic Eyesmentioning

confidence: 99%

Drug Distribution in the Vitreous Humor of the Human Eye: The Effects of Aphakia and Changes in Retinal Permeability and Vitreous Diffusivity

Friedrich¹,

Saville²,

Cheng³

1997

Journal of Ocular Pharmacology and Therapeutics

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The majority of eyes that receive drug therapy exhibit some form of pathophysiological degradation. Two common pathophysiological states are retinal inflammation, which results in breakdown of the blood-retinal barrier, and aphakia. The purpose of this study was to examine the effects of aphakia and changes in retinal permeability and vitreous diffusivity on drug distribution in the vitreous humor of the human eye. The study was performed using a finite element model that accurately accounts for the vitreous geometry and boundary conditions. Intravitreal injection is the most common method for treating posterior segment disorders; therefore, this administration method was simulated using the models. Elimination from aphakic and phakic eyes was compared for four extreme injection locations and for two retinal permeabilities. When the retinal permeability was fixed at 5.0 x 10(-5) cm/s, increasing the drug diffusivity through the vitreous from 5.4 to 10(-7) to 2.4 x 10(-5) cm2/s decreased the half-life of drug from 64 hours to 2.7 hours. When the drug diffusivity was fixed at 5.6 x 10(-6) cm2/s, increasing the retinal permeability of the drug from 1.0 x 10(-7) to 1.0 x 10(-4) cm/s decreased the half-life of drug from 44 to 7 hours. Therefore, drug diffusivity and retinal permeability are key factors that influence elimination from the vitreous, and must be considered, particularly if the blood retinal barrier has been compromised. Faster drug elimination was observed in aphakic eyes than in phakic eyes, especially for drugs with a low retinal permeability and injected close to the lens capsule. Injection position is also important if the drug is injected in close proximity to a primary elimination barrier.

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Corneal and Retinal Complications after Cataract Extraction

Cited by 85 publications

References 16 publications

Retinal detachment and its relation to cataract surgery.

Retinal detachment and its relation to cataract surgery.

Primary retinal reattachment surgery: anatomical and functional outcome in phakic and pseudophakic eyes

Drug Distribution in the Vitreous Humor of the Human Eye: The Effects of Aphakia and Changes in Retinal Permeability and Vitreous Diffusivity

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