Corneal Allograft Rejection Following Immunization

Steinemann, Thomas L.; Koffler, Bruce H.; Jennings, C. Darrell

doi:10.1016/0002-9394(88)90588-0

Cited by 57 publications

(56 citation statements)

References 15 publications

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“…While we did not observe efficient replication of these human viruses in vivo or in vitro, ocular symptoms occur sporadically following influenza infection with seasonal viruses (37). Seasonal influenza vaccination has been associated rarely with the onset of oculo-respiratory syndrome in individuals with no prior history of ocular disease, and there have been sporadic reports of individuals rejecting corneal transplants following vaccination (12,34,35,49). These adverse effects demonstrate the importance of studying the ocular environment in the context of both avian and human influenza virus infection and vaccination.…”

Section: Discussionmentioning

confidence: 99%

Ocular Infection of Mice with Influenza A (H7) Viruses: a Site of Primary Replication and Spread to the Respiratory Tract

Belser

Wadford

et al. 2009

J Virol

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Avian H7 influenza viruses have been responsible for poultry outbreaks worldwide and have resulted in numerous cases of human infection in recent years. The high rate of conjunctivitis associated with avian H7 subtype virus infections may represent a portal of entry for avian influenza viruses and highlights the need to better understand the apparent ocular tropism observed in humans. To study this, mice were inoculated by the ocular route with viruses of multiple subtypes and degrees of virulence. We found that in contrast to human (H3N2 and H1N1) viruses, H7N7 viruses isolated from The Netherlands in 2003 and H7N3 viruses isolated from British Columbia, Canada, in 2004, two subtypes that were highly virulent for poultry, replicated to a significant titer in the mouse eye. Remarkably, an H7N7 virus, as well as some avian H5N1 viruses, spread systemically following ocular inoculation, including to the brain, resulting in morbidity and mortality of mice. This correlated with efficient replication of highly pathogenic H7 and H5 subtypes in murine corneal epithelial sheets (ex vivo) and primary human corneal epithelial cells (in vitro). Influenza viruses were labeled to identify the virus attachment site in the mouse cornea. Although we found abundant H7 virus attachment to corneal epithelial tissue, this did not account for the differences in virus replication as multiple subtypes were able to attach to these cells. These findings demonstrate that avian influenza viruses within H7 and H5 subtypes are capable of using the eye as a portal of entry.

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Section: Discussionmentioning

confidence: 99%

Ocular Infection of Mice with Influenza A (H7) Viruses: a Site of Primary Replication and Spread to the Respiratory Tract

Belser

Wadford

et al. 2009

J Virol

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“…A single case of Guillain-Barré syndrome in a liver transplant recipient and another case of rhabdomyolysis leading to acute allograft dysfunction after IIV vaccination have been reported (388,389). Several case reports of corneal graft rejection have been reported following receipt of IIV (390)(391)(392), but no studies demonstrating an association have been conducted.…”

Section: Immunocompromised Personsmentioning

confidence: 99%

Prevention and Control of Seasonal Influenza with Vaccines

Grohskopf

Sokolow²,

Broder³

et al. 2016

MMWR Recomm. Rep.

381

279

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“…Concomitant conjunctivitis and respiratory disease have been reported among individuals infected with or exposed to H5N1 viruses (11,(112)(113)(114), and seasonal and 2009 H1N1 influenza viruses have also sporadically caused ocular complications following human infection (12,104,115,116). The occurrence of rare adverse events following seasonal influenza virus vaccination, including the onset of oculorespiratory syndrome and the rejection of corneal transplants in vaccine recipients, underscores the importance of studying the ocular environment in the framework of influenza virus infection and vaccination (117)(118)(119)(120). In this context, a recent study demonstrated transocular spread of aerosolized live attenuated influenza virus vaccine (LAIV) to nasopharynx tissue in experimentally exposed individuals (121).…”

Section: Orthomyxovirusesmentioning

confidence: 99%

Ocular Tropism of Respiratory Viruses

Belser

Rota

Tumpey

2013

Microbiol Mol Biol Rev

318

359

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SUMMARY Respiratory viruses (including adenovirus, influenza virus, respiratory syncytial virus, coronavirus, and rhinovirus) cause a broad spectrum of disease in humans, ranging from mild influenza-like symptoms to acute respiratory failure. While species D adenoviruses and subtype H7 influenza viruses are known to possess an ocular tropism, documented human ocular disease has been reported following infection with all principal respiratory viruses. In this review, we describe the anatomical proximity and cellular receptor distribution between ocular and respiratory tissues. All major respiratory viruses and their association with human ocular disease are discussed. Research utilizing in vitro and in vivo models to study the ability of respiratory viruses to use the eye as a portal of entry as well as a primary site of virus replication is highlighted. Identification of shared receptor-binding preferences, host responses, and laboratory modeling protocols among these viruses provides a needed bridge between clinical and laboratory studies of virus tropism.

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Corneal Allograft Rejection Following Immunization

Cited by 57 publications

References 15 publications

Ocular Infection of Mice with Influenza A (H7) Viruses: a Site of Primary Replication and Spread to the Respiratory Tract

Ocular Infection of Mice with Influenza A (H7) Viruses: a Site of Primary Replication and Spread to the Respiratory Tract

Prevention and Control of Seasonal Influenza with Vaccines

Ocular Tropism of Respiratory Viruses

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