Cornea and Sclera

Yanoff, Myron

doi:10.1016/b978-1-4557-2874-9.00008-9

Cited by 2 publications

(1 citation statement)

References 555 publications

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“…Homogentisate 1,2-dioxygenase is involved in the oxidization of homogentisate and prevents the blackening of tissues, also called melanin. In humans, its deficiency causes a metabolic disease called alkaptonuria [ 41 ]. In insects, diverse physiological processes, including wound healing, cuticle tanning, and immunity, are associated with melanization [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Gene Expression Pattern and Regulatory Network of α-Toxin Treatment in Bombyx mori

Feng

Lin

Gong

et al. 2019

International Journal of Genomics

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Bacillus bombyseptieus is a pathogen of Bombyx mori; it can cause bacterial septicemia in silkworm. One of the components of the parasporal crystal toxin of B. bombyseptieus, α-toxin, plays an important role in the process of infection in silkworm. In this study, we investigated the immune response of silkworm induced by α-toxin by using RNA-seq. We compared the changes in gene expression in the midgut, fatbody, and hemocytes of silkworm and in the B. mori embryonic cell line (BmE) after treatment with α-toxin and identified 952 differentially expressed genes and 353 differentially expressed long noncoding RNAs (lncRNAs). These regulated genes in different tissues were found to be enriched in different pathways. The upregulated genes in the midgut were mainly involved in peptidoglycan catabolic process and tyrosine kinase signaling pathway, whereas the downregulated genes were mainly involved in chitin metabolic pathways. The upregulated genes in fatbody were also involved in peptidoglycan catabolic process, but they were for a different peptidoglycan subtype. Further, genes encoding cecropins were enriched in the fatbody. The downregulated genes were mainly involved in the metabolic pathways of fundamental substances such as cellular protein metabolic process and nucleobase-containing compound metabolic process. These results suggest that α-toxin can induce various immune responses in silkworm, and further studies are warranted to understand the mechanism of α-toxin action in silkworm. Further, lncRNAs and differentially expressed genes were correlated using coexpression network analysis. Our findings revealed potential candidate genes and lncRNAs that might play important physiological functions in the immune response to α-toxins in silkworm.

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Section: Resultsmentioning

confidence: 99%

Gene Expression Pattern and Regulatory Network of α-Toxin Treatment in Bombyx mori

Feng

Lin

Gong

et al. 2019

International Journal of Genomics

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A Practical Approach to Ocular Pain for the Non-Ophthalmologist

Waldman

2014

Pain Manag.

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Pain involving the eye has numerous etiologies and is a feared challenge of many clinicians. Between a fear of the patient losing vision and a lack of familiarity with the ophthalmic equipment necessary to diagnose the problem, working up eye pain can be a daunting task. While the ophthalmologist can be indispensable in challenging cases of eye pain, this article will help clarify the unique clinical features of each etiology that can help clinicians narrow down the differential and arrive at a diagnosis.

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Cornea and Sclera

Cited by 2 publications

References 555 publications

Gene Expression Pattern and Regulatory Network of α-Toxin Treatment in Bombyx mori

Gene Expression Pattern and Regulatory Network of α-Toxin Treatment in Bombyx mori

A Practical Approach to Ocular Pain for the Non-Ophthalmologist

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