Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities

Wang, Kai‐Jin; Zhao, Jintong

doi:10.1016/j.biopha.2018.11.126

Cited by 72 publications

(41 citation statements)

References 46 publications

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“…Owing to this, the component analysis is especially important for the comprehensive understanding of TCM. Corn silk, an important TCM comprising the dried yellowish stigma and silk of corn fruit, has been widely applied for disorders such as diabetes , cancer , obesity , hypertension , inflammation , fatigue , and others . Modern studies elucidated that corn silk consists of numerous constituents such as polysaccharides , flavonoids , diterpenoids , alkaloids , steroids , and more .…”

Section: Introductionmentioning

confidence: 99%

Rapid analysis and characterization of multiple constituents of corn silk aqueous extract using ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Wang

Liu

Fan

et al. 2019

J of Separation Science

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Corn silk is a well‐known traditional Chinese medicine that has been widely used for its antidiabetic, antioxidant, antihyperlipidemic, and other effects in China for thousands of years. Numerous studies have revealed that corn silk contains multiple bioactive constituents that are beneficial for human health. However, the constituents of corn silk in vivo remain ambiguous. In this study, high‐throughput ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry technology using multivariate statistical analysis was established to systematically investigate the constituents migrating into blood from corn silk aqueous extract. As a result, 76 compounds were identified, including caffeic acid and ten of its derivatives, (E)‐p‐coumaric acid and two of its derivatives, ferulic acid and four of its derivatives, and five flavones. Among the identified constituents, 21 constituents, including nine prototype components and 12 metabolites derived from eight components, were characterized in sequence. Based on the significance of the results, the applied approach was powerful for the accurate determination and rapid screening of bioactive components from corn silk aqueous extract. The obtained results are valuable for the in‐depth understanding and further pharmacological study of corn silk aqueous extract.

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Section: Introductionmentioning

confidence: 99%

Rapid analysis and characterization of multiple constituents of corn silk aqueous extract using ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Wang

Liu

Fan

et al. 2019

J of Separation Science

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“…The flavanone naringin also attenuates ROS production in diabetic kidneys with concomitant reduction in Nox4 expression and increase in antioxidant enzymes SOD and GPx [74]. In vitro experiments have also demonstrated that the strong anti-oxidant effect of different flavonoids (e.g., corn silk extracts and liquiritigenin) is linked to Nox4 inhibition and SOD induction [68,69,75].…”

Section: Diabetic Nephropathymentioning

confidence: 98%

“…For example, in a rat model of STZ-induced DN combined with high-fat, high-carbohydrate diet, the treatment with mangiferin extracted from Pyrrosiae folium down-regulated IL-6, TNF-α and IL-1β expression and improved renal pathological damage [67]. Similarly, corn silk extract, liquiritigenin and naringin also exhibited anti-inflammatory activity by reducing the expression of IL-1β and IL-18 in mesangial cells exposed to high glucose conditions [68][69][70].…”

Section: Diabetic Nephropathymentioning

confidence: 99%

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Caro-Ordieres

Marín-Royo

Opazo-Ríos

et al. 2020

JCM

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Diabetes mellitus (DM), and its micro and macrovascular complications, is one of the biggest challenges for world public health. Despite overall improvement in prevention, diagnosis and treatment, its incidence is expected to continue increasing over the next years. Nowadays, finding therapies to prevent or retard the progression of diabetic complications remains an unmet need due to the complexity of mechanisms involved, which include inflammation, oxidative stress and angiogenesis, among others. Flavonoids are natural antioxidant compounds that have been shown to possess anti-diabetic properties. Moreover, increasing scientific evidence has demonstrated their potential anti-inflammatory and anti-oxidant effects. Consequently, the use of these compounds as anti-diabetic drugs has generated growing interest, as is reflected in the numerous in vitro and in vivo studies related to this field. Therefore, the aim of this review is to assess the recent pre-clinical and clinical research about the potential effect of flavonoids in the amelioration of diabetic complications. In brief, we provide updated information concerning the discrepancy between the numerous experimental studies supporting the efficacy of flavonoids on diabetic complications and the lack of appropriate and well-designed clinical trials. Due to the well-described beneficial effects on different mechanisms involved in diabetic complications, the excellent tolerability and low cost, future randomized controlled studies with compounds that have adequate bioavailability should be evaluated as add-on therapy on well-established anti-diabetic drugs.

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“…For assay with PNPG, the absorbance was measured at 405 nm for α-glucosidase inhibition. The inhibitory assay using α-amylase from porcine pancreas was performed as previously reported [33]. The blank was prepared by adding potassium phosphate buffer instead of enzyme.…”

Section: Extraction and Isolationmentioning

confidence: 99%

Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus

Chen

Han

et al. 2020

Planta Med

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Hericium erinaceus is a very popular edible and medicinal mushroom used for the treatment of enervation and gastrointestinal diseases in Eastern Asia. Chemical investigation on the fruiting body of Hericium erinaceus led to the isolation of 4 new (1 – 4) and 10 known meroterpenoids (5 – 14). The structures of new compounds were determined via analysis of NMR and MS data in combination with chemical derivatization. The inhibitory activities of 1 – 14 against α-glucosidase were evaluated using p-nitrophenyl-α-D-glucopyranoside, sucrose, or maltose as substrate. Compounds 6, 9, 11 – 13 were demonstrated to show the α-glucosidase inhibitory activities. This work confirms the potential of H. erinaceus in the treatment of diabetes.

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Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities

Cited by 72 publications

References 46 publications

Rapid analysis and characterization of multiple constituents of corn silk aqueous extract using ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

Rapid analysis and characterization of multiple constituents of corn silk aqueous extract using ultra‐high‐performance liquid chromatography combined with quadrupole time‐of‐flight mass spectrometry

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus

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