Corn Mint (Mentha arvensis) Extract Diminishes Acute Chlamydia pneumoniae Infection in Vitro and in Vivo

Salin, Olli; Törmäkangas, Liisa; Leinonen, Maija; Saario, Elise; Hagström, Marja; Ketola, Raimo A.; Saikku, Pekka; Vuorela, Heikki; Vuorela, Pia

doi:10.1021/jf2032473

Cited by 32 publications

(26 citation statements)

References 35 publications

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“…The studies on calcium channel blockers indicate that their administration to C . pneumoniae -infected macrophages rescue the infection from persistence and results in a more productive infection, and similarly, our observations on applying nonspecific (verapamil) or L-type specific (isradipin) calcium channel blockers to infected epithelial cells support the view that these compounds activate rather than suppress the acute infection [11]. The impact of phenolic compounds on L-type channel mediated Ca 2+ influx varies depending on compound structure [49,50].…”

Section: Plant Phenolics As Antichlamydial Agentssupporting

confidence: 64%

“…In this model, treatment with luteolin significantly decreased the bacterial load in the lungs and antibody titers in the bloodstream, but also diminished the inflammatory changes in histological samples of the lung [13]. Similar results have also been obtained with a phenol-rich extract of corn mint [11]. …”

Section: Plant Phenolics As Antichlamydial Agentssupporting

confidence: 55%

“…pneumoniae infection, revealing a decrease in the number of C. pneumoniae -positive animals and C. pneumoniae -specific IgG antibodies among the extract-treated mice. Bioactivity-guided fractionation revealed two phenolic compounds, linarin and rosmarinic acid as the main antichlamydial components of the extract [11]. …”

Section: Lead Discovery Strategiesmentioning

confidence: 99%

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Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors

Hanski

Vuorela

2016

Microorganisms

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Throughout its known history, the gram-negative bacterium Chlamydia pneumoniae has remained a challenging target for antibacterial chemotherapy and drug discovery. Owing to its well-known propensity for persistence and recent reports on antimicrobial resistence within closely related species, new approaches for targeting this ubiquitous human pathogen are urgently needed. In this review, we describe the strategies that have been successfully applied for the identification of nonconventional antichlamydial agents, including target-based and ligand-based virtual screening, ethnopharmacological approach and pharmacophore-based design of antimicrobial peptide-mimicking compounds. Among the antichlamydial agents identified via these strategies, most translational work has been carried out with plant phenolics. Thus, currently available data on their properties as antichlamydial agents are described, highlighting their potential mechanisms of action. In this context, the role of mitogen-activated protein kinase activation in the intracellular growth and survival of C. pneumoniae is discussed. Owing to the complex and often complementary pathways applied by C. pneumoniae in the different stages of its life cycle, multitargeted therapy approaches are expected to provide better tools for antichlamydial therapy than agents with a single molecular target.

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Section: Plant Phenolics As Antichlamydial Agentssupporting

confidence: 64%

Section: Plant Phenolics As Antichlamydial Agentssupporting

confidence: 55%

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Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors

Hanski

Vuorela

2016

Microorganisms

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“…Both the mint extracts and pure compounds exhibited high levels of inhibitory activity in vitro, with low host cell toxicity. In a mouse model, intraperitoneally administered corn mint extracts delivered at nutritionally relevant concentrations resulted in reduced inflammatory symptoms but were not as effective as antibiotics in clearing the infection [53]. Kapp et al, performed an in vitro study on the effect of seven peppermint ( Mentha × piperita L.) tea extracts on C. pneumoniae -infected human cells.…”

Section: Biomedical Phytochemical Groups and Anti-infective Actionmentioning

confidence: 99%

Natural Products for the Treatment of Chlamydiaceae Infections

et al. 2016

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Due to the global prevalence of Chlamydiae, exploring studies of diverse antichlamydial compounds is important in the development of effective treatment strategies and global infectious disease management. Chlamydiaceae is the most widely known bacterial family of the Chlamydiae order. Among the species in the family Chlamydiaceae, Chlamydia trachomatis and Chlamydia pneumoniae cause common human diseases, while Chlamydia abortus, Chlamydia psittaci, and Chlamydia suis represent zoonotic threats or are endemic in human food sources. Although chlamydial infections are currently manageable in human populations, chlamydial infections in livestock are endemic and there is significant difficulty achieving effective treatment. To combat the spread of Chlamydiaceae in humans and other hosts, improved methods for treatment and prevention of infection are needed. There exist various studies exploring the potential of natural products for developing new antichlamydial treatment modalities. Polyphenolic compounds can inhibit chlamydial growth by membrane disruption, reestablishment of host cell apoptosis, or improving host immune system detection. Fatty acids, monoglycerides, and lipids can disrupt the cell membranes of infective chlamydial elementary bodies (EBs). Peptides can disrupt the cell membranes of chlamydial EBs, and transferrins can inhibit chlamydial EBs from attachment to and permeation through the membranes of host cells. Cellular metabolites and probiotic bacteria can inhibit chlamydial infection by modulating host immune responses and directly inhibiting chlamydial growth. Finally, early stage clinical trials indicate that polyherbal formulations can be effective in treating chlamydial infections. Herein, we review an important body of literature in the field of antichlamydial research.

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“…Mentha arvensis belongs to the family Lamiaceae and is famous for its therapeutic and medicinal values since prehistoric times. It has been reported in various studies that plant extracts of Mentha have been found to possess bioactive ingredients that showed antioxidant, antifungal and antibacterial activities [6].…”

mentioning

confidence: 99%

Environmentally Friendly Extraction of Bioactive Compounds from <i>Mentha arvensis</i> Using Deep Eutectic Solvent as Green Extraction Media

Naseem¹,

Zahid²,

Hanif³

et al. 2020

Pol. J. Environ. Stud.

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Volatile organic solvents (VOCs) have a detrimental influence on the environment and human beings. The eutectic-based mixtures actually consist of organic compounds having lower melting points in contrast to their individual constituents [1]. The DESs are one of the alternatives of organic solvents for the extraction of bioactive compounds because of unique physicochemical properties. Characteristically, DES is defined as a mixture of hydrogen bond donors (HBD) and an acceptor system with extensive intermolecular Pol. AbstractIn the present study, deep eutectic solvent (DES) was prepared by combining choline chloride and glycerol and is used as a green alternative extraction media of detrimental organic solvents. The DES and aqueous methanol were used for the ultrasound-assisted extraction (UAE) of bioactive compounds from Mentha arvensis, which have remarkable medicinal values. The optimization of extraction parameters during phytochemical evaluation was done by response surface methodology. The extraction yield obtained with DES was significantly higher than that achieved using aqueous methanol. The total phenolic contents (TPCs) 117 mg GAE/g, total flavonoids contents (TFCs), 80 mg QE/g and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical inhibition 94% was obtained using DES. The antimicrobial activities of extracts were evaluated against S. aureus, E. coli (bacterial strains), F. solani and A. niger (fungal strains) by well diffusion method. The extracts were characterized using LC-MS and showed that chrysin, p-coumaric acid, naringenin, scopoletin, phenylpyruvic acid, pinocembrin, hesperidin, carnosic acid and caffeic acid were the main bioactive components of Mentha arvensis. The DES has shown considerable high extraction yield, which ultimately relates to the higher TPCs, TFCs and DPPH assay compared to aqueous methanol. The DES with extensive hydrogen bonding is of vital importance in the perspective of the environment than traditionally used solvents.

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Corn Mint (Mentha arvensis) Extract Diminishes Acute Chlamydia pneumoniae Infection in Vitro and in Vivo

Cited by 32 publications

References 35 publications

Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors

Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors

Natural Products for the Treatment of Chlamydiaceae Infections

Environmentally Friendly Extraction of Bioactive Compounds from <i>Mentha arvensis</i> Using Deep Eutectic Solvent as Green Extraction Media

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