Corn distillers solubles as a novel bioresource of bioactive peptides with ACE and DPP IV inhibition activity: characterization, in silico evaluation, and molecular docking

Abstract

The study aimed to investigate the biological potential of underutilized and low-value corn distillers solubles, containing a unique unexplored blend of heat-treated corn and yeast proteins, from bioethanol industries, by...

Identification, rapid screening, docking mechanism and in vitro digestion stability of novel DPP-4 inhibitory peptides from wheat gluten with ginger protease

“…18,34 The positive inhibitors including IPI, sitagliptin, and omarigliptin were chosen to test the molecular docking methods, and the results showed that IPI, sitagliptin, and omarigliptin had a lower average binding energy with Δ G values of −6.04 ± 0.53, −7.12 ± 0.54, and −7.38 ± 0.41 kcal mol −1 , respectively (Table S2†). Notably, the minimum binding energy (Δ G min ) of sitagliptin was −8.10 kcal mol −1 , which was close to the binding energy of sitagliptin reported by Sharma et al 35…”

Purification, identification and molecular docking of dual‐functional peptides derived from corn protein hydrolysates with antioxidant and antiadhesive activity against Helicobacter pylori

“…Enzymatic hydrolysis considerably improves the solubility and functional characteristics of CGM, and the corn peptides also have a variety of potential biological effects. 19,20 Helicobacter pylori can adhere to and colonize GES-1 cells through specific binding between adhesins on the H. pylori surface and receptors on GES-1 cells. Studies have reported that some polysaccharides could inhibit H. pylori adhesion to GES-1 cells as receptor analogs or adhesin analogs.…”

“…It mostly consists of zein and glutelin and has poor solubility, which restricts its range of applications. Enzymatic hydrolysis considerably improves the solubility and functional characteristics of CGM, and the corn peptides also have a variety of potential biological effects 19,20 …”

Growth performance of broiler chickens fed diets supplemented with amylase and protease enzymes individually or combined

“… Kaczmarek et al (2014) and Ghazi et al (2002) found no difference in growth and yield in broiler chicks administered protease-supplemented feed, which may result from the higher rate of starch digestion in the upper gastrointestinal tract. Maize has been discovered to contain protease and some other inhibitors ( Sharma et al , 2022 ). The poly functional Hageman factor inhibitor derived from maize inhibited endogenous protease and amylase activity, which resulted in poor growth performance ( Choct et al , 2006 ).…”