Corino-andrade disease (familial amyloidotic polineuropathy type I) in Spain: Urological and andrological disorders

Villaplana, G. Hita; Rosino, E. Hita; Cubillana, P. López; Egea, L. Asensio; Pertusa, P. Martínez; Albacete, M. Pérez

doi:10.1002/(sici)1520-6777(1997)16:1<55::aid-nau7>3.0.co;2-d

Cited by 18 publications

(12 citation statements)

References 12 publications

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“…Since patients are unaware of impaired bladder sensation, they should be instructed to perform scheduled voiding, as this help prevent injury from over distending the bladder. Liver transplantation is also reported to ameliorate LUT dysfunction in ATTR amyloidosis [16,25].…”

Section: Discussionsupporting

confidence: 61%

“…Amyloid neuropathies are rare [5,9,13], and few urodynamic studies have been performed [16,23,25]. One study [23] investigated a 32-year-old male patient with ATTR transthyretin-type amyloidosis; AL immunoglobulin light-chain-type amyloidosis; BJP Bence-Jones protein; np not performed; NE norepinephrine; H/M ratio heart-tomediastinum ratio; MIBG metaiodobenzylguanidine; SNAP sensory nerve action potential; CMAP compound muscle action potential ATTR amyloidosis, with a 4-year history of voiding difficulty.…”

Section: Discussionmentioning

confidence: 99%

“…Villaplana et al [25] investigated urinary dynamics in a larger series of patients with ATTR amyloidosis. Parameters indicated normal bladder sensation, normal bladder compliance (during the storage phase), poor urinary flow and high post-void residual volume.…”

Section: Discussionmentioning

confidence: 99%

“…Impaired autonomic control of the LUT manifests itself in both difficulty voiding (thus retention of urine) and urinary incontinence [16,23,25]. Autonomic control of the LUT maintains pressure gradients.…”

Section: Introductionmentioning

confidence: 99%

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Urinary dysfunction and autonomic control in amyloid neuropathy

et al. 2006

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Uro-neurological assessment was performed in four patients with small-fiber neuropathy due to amyloidosis (2 transthyretin-type/2 immunoglobulin light-chain-type). Voiding difficulties were due to detrusor weakness and impaired bladder sensation. In two patients cholinesterase inhibition treatment caused urge incontinence, indicating detrusor denervation supersensitivity. The underlying mechanisms of urinary dysfunction seem to involve postganglionic cholinergic and afferent somatic nerves.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urinary dysfunction and autonomic control in amyloid neuropathy

et al. 2006

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“…Treatment with sildenafil has been reported to have an effect on the erectile function 21 , but injection therapy was preferred by our patients even though one patient used sildenafil occasionally. Another problem for male FAP patients is retrograde ejaculation caused by the autonomic neuropathy 22 , but this has not been investigated, and would also have precluded conception.…”

Section: Discussionmentioning

confidence: 99%

Successful pregnancies and fatherhood in familial amyloidotic polyneuropathy (FAP Val30Met) patients with liver transplantation

Holmgren

Lundgren

Suhr

2004

Amyloid

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For familial amyloidotic polyneuropathy (FAP) patients, several problems regarding reproduction are present. For males, erectile dysfunction and retrograde ejaculation are well known complications of the disease In addition, the risk of transferring a fatal disease to their offspring is a matter of concern for the patients. For transplanted fertile patients, the risk of side effects of immunosupression therapy causing congenital malformations must be addressed, and for female patients the additional risk of complications during pregnancy and delivery is a case of concern. After delivery, the problem of breast-feeding arises. In the Swedish population of transplanted patients, five successful pregnancies, of which male FAP recipients fathered three, are reported. All patients were on stable immunosuppressive therapy with cyclosporine or tacrolimus and prednisolone. From our experience, successful fatherhood and pregnancy is possible for liver transplanted FAP patients, as it has been reported for patients transplanted for other medical reasons.

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Lower urinary tract dysfunction in familial amyloidotic polyneuropathy, Portuguese Type

Andrade¹

2008

Neurourology and Urodynamics

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In addition to reduced sensation, underactive detrusor, opening of the vesical neck and external sphincter deficit, we found data suggesting failure of relaxation of the internal and external sphincter. The overdistention associated with an open vesical neck and external sphincter deficit justifies incontinence in those patients. The retention is due to inadequate contraction of the detrusor, probably associated with non-relaxing of the internal and external sphincter. These dysfunctions derive from deposition of amyloid substance in the detrusor, but overdistention is likely to play a role. Early therapeutic intervention in these patients is vital to avoid secondary injuries.

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Corino-andrade disease (familial amyloidotic polineuropathy type I) in Spain: Urological and andrological disorders

Cited by 18 publications

References 12 publications

Urinary dysfunction and autonomic control in amyloid neuropathy

Urinary dysfunction and autonomic control in amyloid neuropathy

Successful pregnancies and fatherhood in familial amyloidotic polyneuropathy (FAP Val30Met) patients with liver transplantation

Lower urinary tract dysfunction in familial amyloidotic polyneuropathy, Portuguese Type

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