Corin in clinical laboratory diagnostics

Dong, Ningzheng; Chen, Shenghan; Wang, Wei; Zhou, Yiqing; Wu, Qingyu

doi:10.1016/j.cca.2011.10.032

Cited by 61 publications

(58 citation statements)

References 96 publications

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“…Soluble corin in the circulation was measured by the ELISA assays in most studies. 8,[14][15][16] In this study, we also used commercially ELISA assays to measure the serum soluble corin for all participants. The range of serum corin (373.4-2833.3 pg/mL) detected in nonhypertensive individuals in our controls was similar to that (296-2590 pg/mL) in the previous report.…”

Section: Discussionmentioning

confidence: 99%

Serum Soluble Corin Is Decreased in Stroke

Peng

Zhu

Shi

et al. 2015

Stroke

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Background and Purpose-Soluble corin was decreased in coronary heart disease. Given the connections between cardiac dysfunction and stroke, circulating corin might be a candidate marker of stroke risk. However, the association between circulating corin and stroke has not yet been studied in humans. Here, we aimed to examine the association in patients wtith stroke and community-based healthy controls. Methods-Four hundred eighty-one patients with ischemic stroke, 116 patients with hemorrhagic stroke, and 2498 healthy controls were studied. Serum soluble corin and some conventional risk factors of stroke were examined. Because circulating corin was reported to be varied between men and women, the association between serum soluble corin and stroke was evaluated in men and women, respectively. Results-Patients

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Section: Discussionmentioning

confidence: 99%

Serum Soluble Corin Is Decreased in Stroke

Peng

Zhu

Shi

et al. 2015

Stroke

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“…Corin antigen and activity have been detected in human blood (43)(44)(45)(46). Studies indicate that the levels of plasma soluble corin and activity are significantly lower in patients with hypertension and heart failure (43,47,48), suggesting that the reduced corin activity may contribute to hypertensive disease.…”

Section: Discussionmentioning

confidence: 99%

Corin Mutation R539C from Hypertensive Patients Impairs Zymogen Activation and Generates an Inactive Alternative Ectodomain Fragment

Dong

Fang

Jiang

et al. 2013

Journal of Biological Chemistry

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Background: Corin is a membrane serine protease that activates natriuretic peptides in the heart. Results: The corin mutant R539C identified in hypertensive patients has impaired zymogen activation and altered ectodomain shedding. Conclusion: The mutation alters corin protein structure and reduces corin activity. Significance: Human CORIN gene mutations causing impaired corin activity may be an underlying mechanism in hypertension.

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“…Corin, a type transmembrane serine protease that primarily expressed in cardiomyocytes, has been identified as physiological natriuretic peptides convertase [6,7]. To literature, corin levels were decreased in some cardiovascular diseases, e.g.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Serum Soluble Corin Levels among Stroke Subtypes

Peng¹,

Hu²,

Zhang³

et al. 2015

J Neurol Neurol Sci Disord

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Background: Serum soluble corin was decreased not only in some cardiac diseases, but also in stroke. Cardiogenic sources play a critical role in ischemic stroke. Serum soluble corin level in stroke subtypes has not been studied. Here we aimed to study corin level in 4 stroke subtypes: hemorrhagic, thrombotic, embolic and lacunar stroke.Methods: 116 hemorrhagic stroke, 320 thrombotic stroke patients, 48 embolic stroke patients and 102 lacunar stroke patients were studied. Serum soluble corin was measured and some conventional risk factors of stroke were collected. We compared corin level among different types of stroke in men and women respectively. Results: Serum soluble corin level was significantly higher in ischemic stroke patients than hemorrhagic stroke patients in men (log-corin, mean±SD:7.53±0.34 vs. 7.42±0.28; P =0.013) and women (log-corin, mean±SD:7.22±0.27 vs. 7.12±0.31; P = 0.044). Then we studied serum soluble corin in subtypes of ischemic stroke. Unadjusted analysis failed to show a significant difference in logtransformed serum soluble corin among different ischemic stroke subtypes in both men and women. However, after adjustment for the covariables, the mean level of log-transformed serum soluble corin was significantly increased in embolic stroke patients compared with other subtypes in men (P <0.05). In women, embolic stroke patients also had the highest mean level of log-transformed serum soluble corin but with no significant difference. After excluding patients with a history of coronary heart disease, the mean level of serum soluble corin was still the highest in embolic stroke patients among men and women however with no significance.Conclusions: Serum soluble corin was higher in ischemic stroke than hemorrhagic stroke and the highest in embolic stroke. Our findings indicated that corin may be a candidate biomarker used in the differentiate diagnosis of embolism from the heart.

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Corin in clinical laboratory diagnostics

Cited by 61 publications

References 96 publications

Serum Soluble Corin Is Decreased in Stroke

Serum Soluble Corin Is Decreased in Stroke

Corin Mutation R539C from Hypertensive Patients Impairs Zymogen Activation and Generates an Inactive Alternative Ectodomain Fragment

Comparison of Serum Soluble Corin Levels among Stroke Subtypes

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