Corin Deficiency Alters Adipose Tissue Phenotype and Impairs Thermogenesis in Mice

Zhang, Xianrui; Li, Wenguo; Zhou, Tiantian; Li, Meng; Wu, Qingyu; Dong, Ningzheng

doi:10.3390/biology11081101

Cited by 4 publications

(11 citation statements)

References 72 publications

(102 reference statements)

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“…These data indicate that corin deficiency prevents ANP generation, thereby impairing cGKI/hormone-sensitive lipase-mediated lipolysis and the p38 Mapk-Pgc-1α-Ucp1 signaling pathway in adipose tissue browning in mice (Figure 4). expression were also observed in BAT from Corin KO mice [144]. In culture, ANP ment increased Ucp1 expression in BAT-derived adipocytes from Corin KO mice These data indicate that corin deficiency prevents ANP generation, thereby imp cGKI/hormone-sensitive lipase-mediated lipolysis and the p38 Mapk-Pgc-1α-Ucp1 s ing pathway in adipose tissue browning in mice (Figure 4).…”

Section: Impaired Adipose Tissue Browning and Thermogenesis In Corin ...mentioning

confidence: 68%

“…Moreover, decreased p38 Mapk phosphorylation, Pgc-1α levels, and mitochondrial gene expression were also observed in BAT from Corin KO mice [144]. In culture, ANP treatment increased Ucp1 expression in BAT-derived adipocytes from Corin KO mice [144]. These data indicate that corin deficiency prevents ANP generation, thereby impairing cGKI/hormone-sensitive lipase-mediated lipolysis and the p38 Mapk-Pgc-1α-Ucp1 signaling pathway in adipose tissue browning in mice (Figure 4).…”

Section: Impaired Adipose Tissue Browning and Thermogenesis In Corin ...mentioning

confidence: 86%

“…Given the role of ANP in adipose tissue, it is anticipated that corin deficiency may alter adipose tissue phenotype. Indeed, a recent study reported that Corin KO mice had impaired adipocyte browning, as observed in ANP KO mice [144]. Particularly, Corin KO mice had an increased fat mass/body weight ratio, larger adipocyte sizes in WAT, and reduced Ucp1 and Cidea expression in BAT.…”

Section: Impaired Adipose Tissue Browning and Thermogenesis In Corin ...mentioning

confidence: 88%

“…Particularly, Corin KO mice had an increased fat mass/body weight ratio, larger adipocyte sizes in WAT, and reduced Ucp1 and Cidea expression in BAT. Moreover, decreased p38 Mapk phosphorylation, Pgc-1α levels, and mitochondrial gene expression were also observed in BAT from Corin KO mice [144]. In culture, ANP treatment increased Ucp1 expression in BAT-derived adipocytes from Corin KO mice [144].…”

Section: Impaired Adipose Tissue Browning and Thermogenesis In Corin ...mentioning

confidence: 88%

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Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function

Zhang

et al. 2023

Biomedicines

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Adipose tissue is a crucial organ in energy metabolism and thermoregulation. Adipose tissue phenotype is controlled by various signaling mechanisms under pathophysiological conditions. Type II transmembrane serine proteases (TTSPs) are a group of trypsin-like enzymes anchoring on the cell surface. These proteases act in diverse tissues to regulate physiological processes, such as food digestion, salt-water balance, iron metabolism, epithelial integrity, and auditory nerve development. More recently, several members of the TTSP family, namely, hepsin, matriptase-2, and corin, have been shown to play a role in regulating lipid metabolism, adipose tissue phenotype, and thermogenesis, via direct growth factor activation or indirect hormonal mechanisms. In mice, hepsin deficiency increases adipose browning and protects from high-fat diet-induced hyperglycemia, hyperlipidemia, and obesity. Similarly, matriptase-2 deficiency increases fat lipolysis and reduces obesity and hepatic steatosis in high-fat diet-fed mice. In contrast, corin deficiency increases white adipose weights and cell sizes, suppresses adipocyte browning and thermogenic responses, and causes cold intolerance in mice. These findings highlight an important role of TTSPs in modifying cellular phenotype and function in adipose tissue. In this review, we provide a brief description about TTSPs and discuss recent findings regarding the role of hepsin, matriptase-2, and corin in regulating adipose tissue phenotype, energy metabolism, and thermogenic responses.

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Section: Impaired Adipose Tissue Browning and Thermogenesis In Corin ...mentioning

confidence: 68%

Section: Impaired Adipose Tissue Browning and Thermogenesis In Corin ...mentioning

confidence: 86%

Section: Impaired Adipose Tissue Browning and Thermogenesis In Corin ...mentioning

confidence: 88%

Section: Impaired Adipose Tissue Browning and Thermogenesis In Corin ...mentioning

confidence: 88%

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Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function

Zhang

et al. 2023

Biomedicines

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“…Additionally, ANP promotes the browning program in adipocytes, as indicated by increased uncoupling protein 1 (UCP1) and mitochondrial gene expression, via PKG-p38 mitogen-activated protein kinase (MAPK) signaling [66]. Consistently, Nppa and Corin KO mice exhibit impaired adipose tissue browning and poor thermogenic response upon cold exposure [67,68].…”

Section: Lipid Metabolism and Adipose Tissue Phenotypementioning

confidence: 99%

Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

2023

IJMS

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Endometrial decidualization is a uterine process essential for spiral artery remodeling, embryo implantation, and trophoblast invasion. Defects in endometrial decidualization and spiral artery remodeling are important contributing factors in preeclampsia, a major disorder in pregnancy. Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood volume and pressure. ANP is also generated in non-cardiac tissues, such as the uterus and placenta. In recent human genome-wide association studies, multiple loci with genes involved in natriuretic peptide signaling are associated with gestational hypertension and preeclampsia. In cellular experiments and mouse models, uterine ANP has been shown to stimulate endometrial decidualization, increase TNF-related apoptosis-inducing ligand expression and secretion, and enhance apoptosis in arterial smooth muscle cells and endothelial cells. In placental trophoblasts, ANP stimulates adenosine 5′-monophosphate-activated protein kinase and the mammalian target of rapamycin complex 1 signaling, leading to autophagy inhibition and protein kinase N3 upregulation, thereby increasing trophoblast invasiveness. ANP deficiency impairs endometrial decidualization and spiral artery remodeling, causing a preeclampsia-like phenotype in mice. These findings indicate the importance of natriuretic peptide signaling in pregnancy. This review discusses the role of ANP in uterine biology and potential implications of impaired ANP signaling in preeclampsia.

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The serine protease CORIN promotes progression of gastric cancer by mediating the ERK1/2 MAPK pathway

Hong,

Zhang,

Zhang

et al. 2024

Molecular Carcinogenesis

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The serine protease CORIN catalyzes pro‐atrial natriuretic peptide (pro‐ANP) into an active ANP and maintains homeostasis of the internal environment. However, it is unclear whether CORIN participates in the regulation of tumor progression. We analyzed the expression profile of CORIN in gastric cancer tissues (GCs) and adjacent nontumoral tissues (NTs). We investigated the prognostic value of CORIN in GC patients. We characterized the in vitro and in vivo activity of CORIN in cultured GC cells with gain‐of‐function and loss‐of‐function experiments. The underlying mechanism was explored by using bioinformatics, a signaling antibody array, and confirmative western blot analyses, as well as rescue experiments with highly selective small‐molecule inhibitors targeting the ERK1/2 MAPK signaling pathway. CORIN was upregulated in GCs than in NTs. Overexpression of CORIN was correlated with unfavorable prognoses in patients with GC. Ectopic expression of CORIN was promoted, whereas silencing of CORIN suppressed proliferation, colony formation, migration and invasion of GC cells, and tumor growth in vivo. Overexpression of CORIN‐induced epithelial‐mesenchymal transition (EMT) and activation of the ERK1/2 MAPK signaling pathway, while silencing of CORIN yielded opposite results. The in vitro tumor‐promoting potency of CORIN could be antagonized by selective inhibitors targeting the ERK1/2 MAPK pathway. In conclusion, CORIN is a potential prognostic marker and therapeutic target for GC patients, which may promote tumor progression by mediating the ERK1/2 MAPK signaling pathway and EMT in GC cells.

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Corin Deficiency Alters Adipose Tissue Phenotype and Impairs Thermogenesis in Mice

Cited by 4 publications

References 72 publications

Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function

Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function

Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

The serine protease CORIN promotes progression of gastric cancer by mediating the ERK1/2 MAPK pathway

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