Corelation between microvascular density (MVD) with the time to appearance of the metastasis in the patients with breast cancer

Gojkovic, Zdenka; Jakovljević, Branko; Maksimović, Siniša; Topic, Brano; Jungić, Saša; Rakita, Ivanka; Dasic, Predrag; Vještica, Milka

doi:10.1016/j.breast.2011.08.040

Cited by 2 publications

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“…Angiogenesis promoted the proliferation ability of breast cancer cells and shortened the metastasis time. With the increase in the microvascular density grade, the time to metastasis was shorter [37] . This evidence has demonstrated that angioge -nesis has a certain correlation with tumor growth and progression.…”

Section: Discussionmentioning

confidence: 98%

Comprehensive analysis prediction prognosis and immune therapy value of angiogenesis-associated genes in kidney renal clear cell carcinoma

Aimudula

Maimaitiming

Zhang

et al. 2022

Preprint

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Background:Kidney renal clear cell carcinoma (KIRC) is a highly vascularized and immunogenic tumor that has a high percentage of recurrence and a poor prognosis. Anti-angiogenesis therapies and immunotherapy are critical options to treat KIRC. However, the role of angiogenesis-associated genes (AAGs) in renal cell carcinoma tumorigenesis, prognosis prediction, the influence of the tumor microenvironment (TME) and the response to immunotherapy remains unknown. Identifying potential prognostic markers based on AAGs of KIRC may provide information for the early detection of recurrence and treatment. Methods: We investigated the expression profiles of 36 AAGs in 536 KIRC patients, including 536 tumors and 72 adjacent nontumor tissues downloaded fromThe Cancer Genome Atlas (TCGA) database. We determined two different clusters based on AAG expression patterns and comprehensively identified the correlation between angiogenesis and patient risk, overall survival, and immune cell proportion in the TME. Next, we assessed the AAG score in different AAG clusters and confirmed the predictive ability in KIRC patients by a risk score model. Finally, we evaluatedthe IC50 of 12 chemotherapy and targeted drugs in different AAG score groups. Results: We explored the expression levels, CNVs, and mutations of 36 AAGs in KIRC and observed that fifteen differentially expressed genes and VEGFA, TIMP1, VCAN and POSTN were hub genes. Different AAG clusters were divided by theexpression profiles of AAGs, and the survival analysis indicated that the low AAG score and low-risk group demonstrated superior overall survival (OS). We analyzed the correlation between angiogenesis and the TME and found that TME scores in the high AAG score group were higher than those in the low AAG score group. The two clusters had an abundance of metabolic-associated pathways. Next, the clinical viability and OS prediction ability of the AAG score in KIRC patients wereconfirmed by a highly reliable nomogram. Furthermore, different TMB subgroups combined with the AAG_score showed that the low-TMB+low-risk group had greater OS. Additionally, the AAG_score was markedly correlated with chemotherapy and target drug susceptibility. Conclusion: Our results reveal that as a clinical prognostic signature, AAGs play a significant predictive role in KIRC. The relationship between AAGs and the TME should provide more potent combination therapy options for KIRC patients.

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Section: Discussionmentioning

confidence: 98%

Comprehensive analysis prediction prognosis and immune therapy value of angiogenesis-associated genes in kidney renal clear cell carcinoma

Aimudula

Maimaitiming

Zhang

et al. 2022

Preprint

View full text Add to dashboard Cite

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Potential of natural flavonoids to target breast cancer angiogenesis (review)

Wang,

Huang,

Zhou

et al. 2024

British J Pharmacology

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Angiogenesis is the process by which new blood vessels form and is required for tumor growth and metastasis. It helps in supplying oxygen and nutrients to tumor cells and plays a crucial role in the local progression and distant metastasis of, and development of treatment resistance in breast cancer. Tumor angiogenesis is currently regarded as a critical therapeutic target; however, anti‐angiogenic therapy for breast cancer fails to produce satisfactory results, owing to issues such as inconsistent efficacy and significant adverse reactions. As a result, new anti‐angiogenic drugs are urgently needed. Flavonoids, a class of natural compounds found in many foods, are inexpensive, widely available, and exhibit a broad range of biological activities, low toxicity, and favorable safety profiles. Several studies find that various flavonoids inhibit angiogenesis in breast cancer, indicating great therapeutic potential. In this review, we summarize the role of angiogenesis in breast cancer and the potential of natural flavonoids as anti‐angiogenic agents for breast cancer treatment. We discuss the value and significance of nanotechnology for improving flavonoid absorption and utilization and anti‐angiogenic effects, as well as the challenges of using natural flavonoids as drugs.

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Corelation between microvascular density (MVD) with the time to appearance of the metastasis in the patients with breast cancer

Cited by 2 publications

References 0 publications

Comprehensive analysis prediction prognosis and immune therapy value of angiogenesis-associated genes in kidney renal clear cell carcinoma

Comprehensive analysis prediction prognosis and immune therapy value of angiogenesis-associated genes in kidney renal clear cell carcinoma

Potential of natural flavonoids to target breast cancer angiogenesis (review)

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