Core-shell structured molecularly imprinted materials for sensing applications

Bhogal, Shikha; Kaur, Kuldeep; Malik, Ashok Kumar; Sonne, Christian; Lee, Sang Soo; Kim, Ki‐Hyun

doi:10.1016/j.trac.2020.116043

Cited by 68 publications

(23 citation statements)

References 111 publications

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“…The methods chosen for MIP production with desirable properties and the final configurations clearly depend on the target molecule (e.g., the whole target or a small fragment as an epitope, small, or large macromolecules) and application, also considering the costs and simplicity of the processes. MIPs is a thriving research subject and comprehensive reviews can be found in the literature covering methods of polymer fabrication and imprinting strategies, range of applications, and integration in biosensing devices [ 43 , 46 , 56 , 62 , 63 ].…”

Section: Molecular Imprinting Technologymentioning

confidence: 99%

Molecular Imprinting on Nanozymes for Sensing Applications

et al. 2021

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As part of the biomimetic enzyme field, nanomaterial-based artificial enzymes, or nanozymes, have been recognized as highly stable and low-cost alternatives to their natural counterparts. The discovery of enzyme-like activities in nanomaterials triggered a broad range of designs with various composition, size, and shape. An overview of the properties of nanozymes is given, including some examples of enzyme mimics for multiple biosensing approaches. The limitations of nanozymes regarding lack of selectivity and low catalytic efficiency may be surpassed by their easy surface modification, and it is possible to tune specific properties. From this perspective, molecularly imprinted polymers have been successfully combined with nanozymes as biomimetic receptors conferring selectivity and improving catalytic performance. Compelling works on constructing imprinted polymer layers on nanozymes to achieve enhanced catalytic efficiency and selective recognition, requisites for broad implementation in biosensing devices, are reviewed. Multimodal biomimetic enzyme-like biosensing platforms can offer additional advantages concerning responsiveness to different microenvironments and external stimuli. Ultimately, progress in biomimetic imprinted nanozymes may open new horizons in a wide range of biosensing applications.

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Section: Molecular Imprinting Technologymentioning

confidence: 99%

Molecular Imprinting on Nanozymes for Sensing Applications

et al. 2021

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“…MIP-based optical sensors have been one of the most preferred technologies by researchers, which has greatly broadened the field of sensors for MIPs due to the simplicity of preparation, low achievable detection limits, and good visualization of expected effects. Nowadays, with the rapid development of nanomaterial types, materials such as quantum dots (Bhogal et al, 2020), magnetic nanoparticles (Chepyala, 2020), nanosilver/gold (Mahmoudpour et al, 2020), metal-organic frameworks (Svitkova and Palchetti, 2020), and graphene oxide (Pandey et al, 2020) exhibit their unique optical properties of narrow emission and resistance to fluorescence bursting, which have great potential for fluorescent sensors, probes and labels. For instance: Cao et al (2020) established a sensitive fluorescence sensor for the detection of octopamine (OA).…”

Section: Mip-based Optical Sensorsmentioning

confidence: 99%

Recent Advances and Future Trends in the Detection of Contaminants by Molecularly Imprinted Polymers in Food Samples

Gao

Chen

et al. 2020

Front. Chem.

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Drug residues, organic dyes, heavy metals, and other chemical pollutants not only cause environmental pollution, but also have a serious impact on food safety. Timely and systematic summary of the latest scientific advances is of great importance for the development of new detection technologies. In particular, molecularly imprinted polymers (MIPs) can mimic antibodies, enzymes and other biological molecules to recognize, enrich, and separate contaminants, with specific recognition, selective adsorption, high affinity, and strong resistance characteristics. Therefore, MIPs have been widely used in chemical analysis, sensing, and material adsorption. In this review, we first describe the basic principles and production processes of molecularly imprinted polymers. Secondly, an overview of recent applications of molecularly imprinted polymers in sample pre-treatment, sensors, chromatographic separation, and mimetic enzymes is highlighted. Finally, a brief assessment of current technical issues and future trends in molecularly imprinted polymers is also presented.

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“…Compared to other expensive biomolecule recognition units (aptamer, antibody and peptide), molecular imprinting is an effective technique for simulating molecular recognition through molecularly imprinted polymers (MIPs) called artificial receptors [26,27]. MIP is formed by copolymerization of template molecules (targets) and functional monomers, which are then removed to produce the memory cavities toward the target with complementary shapes, sizes and functions [28]. The memory cavities can recognize the target by "locking and bonding" mechanisms [29].…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymer Functionalized Bi2S3/Ti3C2TX MXene Nanocomposites for Photoelectrochemical/Electrochemical Dual-Mode Sensing of Chlorogenic Acid

et al. 2022

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We report the proof-of-concept of molecularly imprinted polymer (MIP) functionalized Bi2S3/Ti3C2TX MXene nanocomposites for photoelectrochemical (PEC)/electrochemical (EC) dual-mode sensing of chlorogenic acid (CGA). Specifically, the in-situ growth of the Bi2S3/Ti3C2TX MXene served as a transducer substrate for molecularly imprinted polymers such as PEC and EC signal generators, due to its high surface area, suitable bandwidth and abundant active sites. In addition, the chitosan as a binder was encapsulated into MIP by means of phase inversion on a fluorine-doped tin dioxide (FTO) electrode. In the determination of CGA as an analytical model, the dual-mode sensor based on MIP functionalized Bi2S3/Ti3C2TX MXene nanocomposites had good selectivity, excellent stability and acceptable reproducibility, which displayed a linear concentration range from 0.0282 μM to 2824 μM for the PEC signal and 0.1412 μM to 22.59 μM for the EC signal with a low detection limit of 2.4 nM and 43.1 nM, respectively. Importantly, two dual-response mode with different transduction mechanisms could mutually conform to dramatically raise the reliability and accuracy of detection compared to single-mode detection. This work is a breakthrough for the design of dual-mode sensors and will provide a reasonable basis for the construction of dual-mode sensor platforms.

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Core-shell structured molecularly imprinted materials for sensing applications

Cited by 68 publications

References 111 publications

Molecular Imprinting on Nanozymes for Sensing Applications

Molecular Imprinting on Nanozymes for Sensing Applications

Recent Advances and Future Trends in the Detection of Contaminants by Molecularly Imprinted Polymers in Food Samples

Molecularly Imprinted Polymer Functionalized Bi2S3/Ti3C2TX MXene Nanocomposites for Photoelectrochemical/Electrochemical Dual-Mode Sensing of Chlorogenic Acid

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