Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering

Szymusiak, Magdalena; Kalkowski, Joseph; Luo, Hanying; Donovan, Alexander J.; Zhang, Pin; Liu, Chang; Shang, Weifeng; Irving, Thomas C.; Herrera‐Alonso, Margarita; Liu, Ying

doi:10.1021/acsmacrolett.7b00490

Cited by 41 publications

(37 citation statements)

References 21 publications

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“…Firstly, CrEL was dissolved in short chain alcohol-EtOH as a co-surfactant for the effective formation and stability of a nano-emulsion [27]. As a result, the cremophor emulsion with the core-shell micelles type [39] was obtained. The morphology of these micelles is typical of polymeric detergents, among them, CrEL.…”

Section: Cryo-scanning Electron Microscopymentioning

confidence: 99%

Cremophor EL Nano-Emulsion Monomerizes Chlorophyll a in Water Medium

et al. 2019

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In this paper, the application of a non-ionic detergent Cremophor EL for monomerization of chlorophyll a in an aqueous medium is studied. The spectrophotometric properties of chlorophyll a encapsulated into the Cremophor EL nano-emulsion system were characterized by electronic absorption, steady-state and time-resolved fluorescence as well as circular dichroism spectroscopy. The results have shown that chlorophyll a dissolves more efficiently in the aqueous medium containing low-level Cremophor (5 wt%) than at an ethanolic solution even in the concentration of 10−4 M. The molecular organization of the chlorophyll a in the Cremophor EL nano-micelles was also investigated by means of Raman spectroscopy. The spectral changes in the frequency of the C=O stretching group were used to distinguish the aggregation state of chlorophyll. It was revealed that chlorophyll a exists dominantly in the monomeric form in the Cremophor EL aqueous solution. The promising aspect of the use of Cremophor EL nano-emulsion as a delivery system is to maintain stable chlorophyll monomer in an aqueous medium. It would open the potential for a new, practical application of chlorophyll a in medicine, as a dietary supplement or studies on molecular organization of chlorophyll a in the well-defined artificial system.

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Section: Cryo-scanning Electron Microscopymentioning

confidence: 99%

Cremophor EL Nano-Emulsion Monomerizes Chlorophyll a in Water Medium

et al. 2019

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“…Important characteristics affecting physicochemical properties of core-corona nanoparticles, and their drug loading capability can be determined from small-angle scattering data, e.g., density and size of the core, thickness and surface density of the corona, etc. [ 34 , 35 , 36 , 37 , 38 ]. Using SANS, T. Riley et al studied the structure of deuterated P(D,L)LA(d)- b -PEG nanoparticles in aqueous solution, prepared by solvent evaporation method [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin

et al. 2021

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Nanoparticles based on biocompatible methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (mPEG113-b-P(D,L)LAn) copolymers as potential vehicles for the anticancer agent oxaliplatin were prepared by a nanoprecipitation technique. It was demonstrated that an increase in the hydrophobic PLA block length from 62 to 173 monomer units leads to an increase of the size of nanoparticles from 32 to 56 nm. Small-angle X-ray scattering studies confirmed the “core-corona” structure of mPEG113-b-P(D,L)LAn nanoparticles and oxaliplatin loading. It was suggested that hydrophilic oxaliplatin is adsorbed on the core-corona interface of the nanoparticles during the nanoprecipitation process. The oxaliplatin loading content decreased from 3.8 to 1.5% wt./wt. (with initial loading of 5% wt./wt.) with increasing PLA block length. Thus, the highest loading content of the anticancer drug oxaliplatin with its encapsulation efficiency of 76% in mPEG113-b-P(D,L)LAn nanoparticles can be achieved for block copolymer with short hydrophobic block.

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“…The utilization of a conventional two-phase sphere modeling approach could not fully realize the micellar structure with high precision. There were more reports utilizing a two-phase sphere modeling approach [32,33,34] but the outcomes of the analyses were faced with a reoccurring lack of precision. Recently, a more quantitative analysis based on a three-phase ellipsoid modeling approach was introduced to examine polymer micelles [35].…”

Section: Introductionmentioning

confidence: 99%

Micelle Structure Details and Stabilities of Cyclic Block Copolymer Amphiphile and Its Linear Analogues

2019

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In this study, we investigate structures and stabilities of the micelles of a cyclic amphiphile (c-PBA-b-PEO) composed of poly(-n-butyl acrylate) (PBA) and poly(ethylene oxide) (PEO) blocks and its linear diblock and triblock analogues (l-PBA-b-PEO and -l-PBA--b-PEO-b-PBA) by using synchrotron X-ray scattering and quantitative data analysis. The comprehensive scattering analysis gives details and insights to the micellar architecture through structural parameters. Furthermore, this analysis provides direct clues for structural stabilities in micelles, which can be used as a good guideline to design highly stable micelles. Interestingly, in water, all topological polymers are found to form ellipsoidal micelles rather than spherical micelles; more interestingly, the cyclic polymer and its linear triblock analog make oblate-ellipsoidal micelles while the linear diblock analog makes a prolate-ellipsoidal micelle. The analysis results collectively inform that the cyclic topology enables more compact micelle formation as well as provides a positive impact on the micellar structural integrity.

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Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering

Cited by 41 publications

References 21 publications

Cremophor EL Nano-Emulsion Monomerizes Chlorophyll a in Water Medium

Cremophor EL Nano-Emulsion Monomerizes Chlorophyll a in Water Medium

Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin

Micelle Structure Details and Stabilities of Cyclic Block Copolymer Amphiphile and Its Linear Analogues

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