Core-Shell Pd/ZIF-8 Platforms as Diffusion-Controlled Nanoreactors in Living Cells and Tissue Models

Martínez, Raquel Suriá; Carrillo‐Carrión, Carolina; Destito, Paolo; Alvarez, Aitor; Tomás‐Gamasa, María; Pelaz, Beatriz; López, Fernándo; Mascareñas, José L.; Pino, Pablo del

doi:10.2139/ssrn.3528755

Cited by 3 publications

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“…Another alternative proposed by del Pino and co‐workers was the synthesis of nanoreactors composed of a Pd nanocube core and a nanometric imidazolate framework that can catalyze the activation of pro‐fluorophores both in biological media and inside living cells. The fabricated MOF shell plays a double role, preserving the integrity of the catalytic chamber and providing substrate selectivity and biocompatibility [54] . Another work involving the use of MOF structures with PdNP was described by Chen et al., for the bioorthogonal activation of fluorescent Rh110 in aqueous solution and living cells.…”

Section: Bioorthogonal Reactions Using Heterogeneous Catalystsmentioning

confidence: 99%

“…The two images in the fourth row correspond to the fourth deprotection run of bis‐propargyl carbamate‐protected cresyl violet with the same nanoreactor‐preloaded cells (scale bar=200 μm). Reprinted with permission from (a) Jason Miles A. Miller et al., [51] Copyright 2018 American Chemical Society, (b) Paolo Destito et al., [52] Copyright 2019 Royal Society of Chemistry, (c) Raquel Martínez et al., [54] Copyright 2020 Elsevier.…”

Section: Bioorthogonal Reactions Using Heterogeneous Catalystsmentioning

confidence: 99%

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Nanostructured Heterogeneous Catalysts for Bioorthogonal Reactions

et al. 2023

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Bioorthogonal chemistry has inspired a new subarea of chemistry providing a powerful tool to perform novel biocompatible chemospecific reactions in living systems. Following the premise that they do not interfere with biological functions, bioorthogonal reactions are increasingly applied in biomedical research, particularly with respect to genetic encoding systems, fluorogenic reactions for bioimaging, and cancer therapy. This Minireview compiles recent advances in the use of heterogeneous catalysts for bioorthogonal reactions. The synthetic strategies of Pd-, Au-, and Cu-based materials, their applicability in the activation of caged fluorophores and prodrugs, and the possibilities of using external stimuli to release therapeutic substances at a specific location in a diseased tissue are discussed. Finally, we highlight frontiers in the field, identifying challenges, and propose directions for future development in this emerging field.

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Section: Bioorthogonal Reactions Using Heterogeneous Catalystsmentioning

confidence: 99%

Section: Bioorthogonal Reactions Using Heterogeneous Catalystsmentioning

confidence: 99%

Nanostructured Heterogeneous Catalysts for Bioorthogonal Reactions

et al. 2023

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“…Given the porous nature of MOFs, they represent an attractive option to use as an encasing shell. In one example, a Pd nanocube (side length of 24 nm) was encased within a ZIF‐8 shell, a MOF consisting of zinc bridged by 2‐methylimidazole [297] . With an average size of ∼250 nm, these Pd/ZIF‐8 core‐shell particles were then shown capable of not only protecting the nanocatalyst from deactivation, leaking, and aggregation, but also allowed the diffusion‐controlled flow of reactants to come into contact with its palladium core.…”

Section: Nanocarriersmentioning

confidence: 99%

Transition Metal Scaffolds Used To Bring New‐to‐Nature Reactions into Biological Systems

2022

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As a means to develop new tools to manipulate biological systems, transition metals have been looked upon as an area of high potential due to the bioorthogonality of new-to-nature reactions. To facilitate their incorporation into complex biological systems, researchers have mainly focused on the development of metal catalyst complexes, protein scaffolds, and nanocarriers to protect and preserve the biocatalytic activity of transition metals. The intent of this review is to summarize these structural scaffolds, which has steadily allowed researchers to push transition metal usage not previously thought possible within bacteria, mammalian cells, and higherlevel organisms.

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“…By employing this protected, biohybrid catalyst in sequential mode, activity of both reactions could be restored and the stilbene derivatives were obtained with good yields. These approaches to avoid incompatibilities, together with the development in the last decade of a range of metal catalysts for the in vivo activation of profluorophores or prodrugs in mammalian cells, indicate that the challenges and potential incompatibilities associated with using whole microbial cells with transition‐metal catalysts can be overcome [35–47] …”

Section: Introductionmentioning

confidence: 99%

Merging Whole‐cell Biosynthesis of Styrene and Transition‐metal Catalyzed Derivatization Reactions

2021

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The approach of combining enzymatic and transition-metal catalysis has been focused almost exclusively on using purified, isolated enzymes. The use of whole-cell biocatalysis, instead of isolated enzymes, with transition-metal catalysis, however, has been investigated only sparsely to date. Herein we present the development of two transition-metal catalyzed reactions used to derivatize styrene obtained from whole-cell biosynthesis. Using a biocompatible ruthenium cross-metathesis catalyst up to 1.5 mM stilbene could be obtained in the presence of E. coli, which simultaneously produced styrene. Using palladium catalysts and arylboronic acids, titers of up to 1 mM of several stilbene derivatives were obtained. These two transition-metal catalyzed reactions are valuable additions to the toolbox of combined whole-cell biocatalysis and transition-metal catalysis, offering the possibility to supplement biosynthetic pathways with the chemical versatility of abiological transition-metal catalysis.

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Core-Shell Pd/ZIF-8 Platforms as Diffusion-Controlled Nanoreactors in Living Cells and Tissue Models

Cited by 3 publications

References 0 publications

Nanostructured Heterogeneous Catalysts for Bioorthogonal Reactions

Nanostructured Heterogeneous Catalysts for Bioorthogonal Reactions

Transition Metal Scaffolds Used To Bring New‐to‐Nature Reactions into Biological Systems

Merging Whole‐cell Biosynthesis of Styrene and Transition‐metal Catalyzed Derivatization Reactions

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