Core–shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

Abstract

Core–shell particles offer significant advantages in their use for bioimaging and biosensors.

Direct Functional Protein Delivery with a Peptide into Neonatal and Adult Mammalian Inner Ear In Vivo

“… 11 During the past decade, several methods have been explored for protein delivery, including peptides, liposome, nanoparticles, and polymers. 12 , 13 Although these methods have promoted the development of protein delivery, the application is still limited by challenges, including cytotoxicity, low activity, and instability. 14 …”

“…11 During the past decade, several methods have been explored for protein delivery, including peptides, liposome, nanoparticles, and polymers. 12,13 Although these methods have promoted the development of protein delivery, the application is still limited by challenges, including cytotoxicity, low activity, and instability. 14 According to the previous study, the variant of green fluorescent protein (GFP), a class of naturally occurring and engineered proteins with a theoretical net superpositive charge, can be a more effective way to deliver functional proteins than cell-penetrating peptides (CPPs) into cells.…”

Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking

“…Different approaches may be used to modulate the elasticity of such particles, including controlling the materials used in the layers, the number of layers, the density of layer crosslinking, and removing the core of the capsules [164] . For example, core-shell particles that consist of a solid polymeric core inside a lipid shell with cylindrical polymer brushes exhibited excellent elasticity [165] , [166] , [167] . Layer-by-layer capsules synthesized using a silica template exhibited increased stiffness values after replacement of the core with Au nanoparticles [168] .…”

PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

“…As a solution to this limitation, tissue regeneration using microparticles should develop a scaffold to support and hold cells as well as deliver drugs to proliferate and differentiate cells [70]. Furthermore, the PLGA core-shell delivery system has been proved to be promising for biomedical applications, like tissue engineering [27].…”

“…As per our knowledge, several review literatures have been published related to PLGA microspheres for biomedical applications [22][23][24][25]. However, a smaller number of reviews have been reported on the PLGA core-shell microsphere [26,27]. In this review, we summarized the current state of core-shell nano/micro PLGA particles for drug delivery, cancer therapy, and tissue regeneration.…”