Core–shell nanohydrogel structures as tunable delivery systems

Şahiner, Nurettin; Alb, Alina M.; Graves, Richard A; Mandal, Tarun K.; McPherson, Gary L.; Reed, Wayne F.; John, Vijay T.

doi:10.1016/j.polymer.2006.12.014

Cited by 68 publications

(38 citation statements)

References 17 publications

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“…As an example, consider the core-shell gels. The scaffold phase can be made of permanently bound inert colloids and covered with a shell of reversibly bound drug-filled nanoparticles 43,44 . Because of its porosity, the scaffold can be used to contain and deliver large and controllable quantities of drug-filled shell particles that can be released upon an external stimulus, such as a change in temperature or pH.…”

Section: Discussionmentioning

confidence: 99%

Multistep kinetic self-assembly of DNA-coated colloids

et al. 2013

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Equilibrium self-assembly relies on the relaxation of disordered mixtures of building blocks towards an ordered ground state. The main drawback of this traditional approach lies in the kinetic traps that often interrupt the progression of the system towards equilibrium and lead to the formation of arrested phases. The latest techniques to control colloidal interactions open up the possibility of exploiting the tendency to dynamically arrest in order to construct amorphous materials with a specific morphology and local separation between multiple components. Here we propose strategies to direct the gelation of two-component colloidal mixtures by sequentially activating selective interactions. We investigate morphological changes in the structure of the arrested phases both by means of molecular dynamics simulations and experimentally by using DNA-coated colloids. Our approach can be exploited to assemble multicomponent mesoporous materials with possible applications in hybrid photovoltaics, photonics and drug delivery.

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Section: Discussionmentioning

confidence: 99%

Multistep kinetic self-assembly of DNA-coated colloids

et al. 2013

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“…reducing the gastrointestinal (GI) mucosa irritation caused by continuous contact with some bioactives or protecting them against degradation and undesirable chemical reactions; and (iv) Assured stability of such compounds in the GI tract (Kope� cek, 2003;Lin and Met-ters, 2006;Oh et al, 2009;Tokarev and Minko, 2009;Vermon-den et al, 2012). In addition, protein nanohydrogels can be produced easily and designed to spontaneously load biologi-cally active molecules through electrostatic, van-der Waals and/or hydrophobic interactions between the agent and the protein matrix during the gel folding, leading to formation of stable nanostructures in which such compounds become entrapped (Huang et al, 2004;Sahiner et al, 2007;Cerqueira et al, 2014).…”

Section: Nanohydrogelsmentioning

confidence: 99%

Design of whey protein nanostructures for incorporation and release of nutraceutical compounds in food

Ramos

Pereira

Martins

et al. 2017

Critical Reviews in Food Science and Nutrition

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Whey proteins are widely used as nutritional and functional ingredients in formulated foods because they are relatively inexpensive, generally recognized as safe (GRAS) ingredient, and possess important biological, physical, and chemical functionalities. Denaturation and aggregation behavior of these proteins is of particular relevance toward manufacture of novel nanostructures with a number of potential uses. When these processes are properly engineered and controlled, whey proteins may be formed into nanohydrogels, nanofibrils, or nanotubes and be used as carrier of bioactive compounds. This review intends to discuss the latest understandings of nanoscale phenomena of whey protein denaturation and aggregation that may contribute for the design of protein nanostructures. Whey protein aggregation and gelation pathways under different processing and environmental conditions such as microwave heating, high voltage, and moderate electrical fields, high pressure, temperature, pH, and ionic strength were critically assessed. Moreover, several potential applications of nanohydrogels, nanofibrils, and nanotubes for controlled release of nutraceutical compounds (e.g. probiotics, vitamins, antioxidants, and peptides) were also included. Controlling the size of protein networks at nanoscale through application of different processing and environmental conditions can open perspectives for development of nanostructures with new or improved functionalities for incorporation and release of nutraceuticals in food matrices.

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“…56,[309][310] Hereby, the shell serves as a diffusion barrier to prevent leakage of embedded functional compounds. 168,311 Based on this consideration, the work described in this chapter deals with studies to investigate potential synthetic pathways for the formation of multiple stimuli-responsive core/shell nanoparticles containing a hydrogel core.…”

Section: Towards Stimuli-responsive Core/shell Nanoparticles Containimentioning

confidence: 99%

Light-Sensitive Polymeric Nanoparticles Based on Photo-Cleavable Chromophores

Klinger

2013

Springer Theses

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This thesis focuses on the design, synthesis and characterization of novel photo-sensitive microgels and nanoparticles as potential materials for the loading and light-triggered release/accessibility of functional compounds. In order to realize this concept, different approaches to irradiation-dependent response mechanisms have been investigated.Novel light-cleavable divinyl functionalized monomeric crosslinkers based on o-nitrobenzyl derivatives were synthesized and used for the preparation of either PMMA or hydroxyl functionalized PHEMA microgels swellable and degradable in organic solvents. By the introduction of anionic MAA moieties into the PHEMA microgels, this concept was successfully transferred to double stimuli-responsive p(HEMA-co-MAA) hydrogel nanoparticles exhibiting a pH-dependent swelling and light-induced degradation behavior in aqueous media. This sensitivity to two orthogonal triggers is proposed to combine a pHinduced post-formation loading mechanism with a pH-and light-triggered release. In addition, a new class of enzyme-and light-sensitive PAAm microgels based on (meth-)acrylate functionalized dextrans as photo-and enzymatically degradable macromolecular crosslinkers was developed by introducing a photo-labile linker between the enzymatically degradable dextran chain and the polymerizable vinyl moieties. Here, the water solubility of the crosslinkers is assumed to enable an in situ loading approach of hydrophilic compounds.A different approach to the loading of microgels is based on photo-labile covalent microgel-drug conjugates. The first step to the realization of this concept was achieved by the development of a novel functional monomer consisting of a doxorubicin molecule covalently attached to a radically polymerizable methacrylate group via a photo-cleavable linker.Moreover, in order to enable the release of hydrophobic substances in aqueous media, hydrophobic nanoparticles consisting of a photo-resist polymer were designed to be degradable upon irradiation in water. Light-triggered conversion of the initial hydrophobic polymer into hydrophilic PMAA induced in situ particle dissolution and release of nile red.Since the introduction of a stimuli-responsive shell around a microgel is assumed to prevent leakage of embedded compounds, studies on non-stimuli-responsive shell formation around preformed microgel seed particles and the formation of microgel cores in polymeric shells were conducted to investigate potential synthetic pathways to this approach.In a last attempt, the surface of PHEMA and p(HEMA-co-MAA) microgels was functionalized with cinnamoyl groups in order to trigger the (reversible) particles interaction with each other by light-induced [2+2] cycloaddition reactions.

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Core–shell nanohydrogel structures as tunable delivery systems

Cited by 68 publications

References 17 publications

Multistep kinetic self-assembly of DNA-coated colloids

Multistep kinetic self-assembly of DNA-coated colloids

Design of whey protein nanostructures for incorporation and release of nutraceutical compounds in food

Light-Sensitive Polymeric Nanoparticles Based on Photo-Cleavable Chromophores

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