Core-shell nanofibers from poly(vinyl alcohol) based biopolymers using emulsion electrospinning as drug delivery system for cephalexin drug

Hameed, Meera Moydeen Abdul; Padusha, M. Syed Ali; Thamer, Badr M.; Al-Enizi, Abdullah M.; Aldalbahi, Ali; El‐Hamshary, Hany; El‐Newehy, Mohamed H.

doi:10.1080/10601325.2020.1832517

Cited by 36 publications

(24 citation statements)

References 45 publications

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“…Herein, they electrospun a blend of HP-β-CD and epichlorohydrin (ECH) and obtained poly(cyclodextrin-epichlorohydrin) (poly(CD-ECH)) fibers. These fibers which were cross-linked through thermal treatment were shown to be hydrophilic yet stable in water for 24 h. While these examples of cross-linked nanofibers did not demonstrate drug delivery applications, one can easily anticipate that these nanofibers can act as supports for specific loading and release of many drugs, since CDs are known to encapsulate drugs through hydrophobic interactions, as has been demonstrated by authors in related studies. , Likewise, several other reports exploit the advantage of the simplicity of using thermal cross-linking to stabilize otherwise hydrolytically dissolvable nanofibers. , …”

Section: Stabilization Of Hydrophilic Nanofibers Through Covalent Che...mentioning

confidence: 88%

Hydrophilic Cross-Linked Polymeric Nanofibers Using Electrospinning: Imparting Aqueous Stability to Enable Biomedical Applications

Golba

Kalaoglu-Altan

Sanyal

et al. 2021

ACS Appl. Polym. Mater.

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Polymeric nanofibers are finding a growing number of applications in various areas of biomedical sciences such as diagnostics, therapeutic delivery, and tissue engineering. Since such applications entail interfacing these materials with the biological milieu, it is often necessary that these nanofibers are hydrophilic in nature, yet stable in an aqueous environment. To date, several approaches to impart stabilization to polymeric nanofibers obtained using electrospinning have been developed. Various strategies utilizing chemical cross-linking of polymers have been exploited to impart stabilization of functional nanofibers fabricated using polymers that are soluble in the aqueous environment. This review highlights the various approaches developed to date for providing stabilization to hydrophilic polymeric nanofibers, along with showcasing the utilization of hydrophilic polymeric nanofibers in several biomedical applications.

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Section: Stabilization Of Hydrophilic Nanofibers Through Covalent Che...mentioning

confidence: 88%

Hydrophilic Cross-Linked Polymeric Nanofibers Using Electrospinning: Imparting Aqueous Stability to Enable Biomedical Applications

Golba

Kalaoglu-Altan

Sanyal

et al. 2021

ACS Appl. Polym. Mater.

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“…107 Plant oil served as a carrier for this active substance and resisted the subsequent heat treatment at 120 °C, which was carried out to evaporate traces of water for increased intermolecular hydrogen-bonding between PVA/dextran molecules and hence improve mechanical stability of these fibers. Comparative release studies from coaxially and blend-spun nanofibers revealed a rapid release of a water-soluble ciprofloxacin salt, while the emulsion-spun antibiotic in oil exhibited efficient encapsulation with only minor release after 50 h. Subsequently, the authors further investigated the effect of the dextran content on the release kinetics using PVP as the main matrix polymer 108 and other polysaccharides 109 within an analogous system. Dextran content promoted intermolecular hydrogen bonding, thus affecting the viscosity and erosion of the polymer matrix.…”

Section: Dispersion Electrospinningmentioning

confidence: 99%

Electrospinning based on benign solvents: current definitions, implications and strategies

et al. 2022

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“…Emulsion electrospinning is a simple and standard method for preparing nanofibers with a core–shell structure, which could effectively load drugs [ 75 ]. Different from the blend electrospinning mentioned above, the hydrophilic drugs in emulsion electrospinning are usually dissolved in the water phase and then diffused into the oil phase containing surfactants/emulsifiers.…”

Section: Electrospinning Technologymentioning

confidence: 99%

Electrospun Medicated Nanofibers for Wound Healing: Review

et al. 2021

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With the increasing demand for wound care and treatment worldwide, traditional dressings have been unable to meet the needs of the existing market due to their limited antibacterial properties and other defects. Electrospinning technology has attracted more and more researchers’ attention as a simple and versatile manufacturing method. The electrospun nanofiber membrane has a unique structure and biological function similar to the extracellular matrix (ECM), and is considered an advanced wound dressing. They have significant potential in encapsulating and delivering active substances that promote wound healing. This article first discusses the common types of wound dressing, and then summarizes the development of electrospun fiber preparation technology. Finally, the polymers and common biologically active substances used in electrospinning wound dressings are summarized, and portable electrospinning equipment is also discussed. Additionally, future research needs are put forward.

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Core-shell nanofibers from poly(vinyl alcohol) based biopolymers using emulsion electrospinning as drug delivery system for cephalexin drug

Cited by 36 publications

References 45 publications

Hydrophilic Cross-Linked Polymeric Nanofibers Using Electrospinning: Imparting Aqueous Stability to Enable Biomedical Applications

Hydrophilic Cross-Linked Polymeric Nanofibers Using Electrospinning: Imparting Aqueous Stability to Enable Biomedical Applications

Electrospinning based on benign solvents: current definitions, implications and strategies

Electrospun Medicated Nanofibers for Wound Healing: Review

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