Core-shell nanofibers as drug delivery systems

Zupančič, Špela

doi:10.2478/acph-2019-0014

Cited by 57 publications

(28 citation statements)

References 116 publications

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“…The use of nanofibers has been suggested for several biomedical applications, including wound dressing, drug delivery, and tissue engineering [20]. Of these, drug delivery is the most promising, whereby its advantages include high drug loading, a high incorporation efficiency, the simultaneous delivery of diverse therapeutics, an increased surface area, a good mechanical resistance, an enhanced distribution at mucosal surfaces, ease of operation, and cost effectiveness [20,21,22].…”

Section: Introductionmentioning

confidence: 99%

Effects of Electrospinning on the Viability of Ten Species of Lactic Acid Bacteria in Poly(Ethylene Oxide) Nanofibers

et al. 2019

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Lactic acid bacteria can have beneficial health effects and be used for the treatment of various diseases. However, there remains the challenge of encapsulating probiotics into delivery systems with a high viability and encapsulation efficacy. The electrospinning of bacteria is a novel and little-studied method, and further investigation of its promising potential is needed. Here, the morphology, zeta potential, hydrophobicity, average cell mass, and growth characteristics of nine different species of Lactobacillus and one of Lactococcus are characterized. The electrospinning of polymer solutions containing ~10 log colony forming units (CFU)/mL lactic acid bacteria enabled the successful incorporation of all bacterial species tested, from the smallest (0.74 µm; Lactococcus lactis) to the largest (10.82 µm; Lactobacillus delbrueckii ssp. bulgaricus), into poly(ethylene oxide) nanofibers with an average diameter of ~100 nm. All of these lactobacilli were viable after incorporation into nanofibers, with 0 to 3 log CFU/mg loss in viability, depending on the species. Viability correlated with the hydrophobicity and extreme length of lactic acid bacteria, whereas a horizonal or vertical electrospinning set-up did not have any role. Therefore, electrospinning represents a promising method for the incorporation of lactic acid bacteria into solid delivery systems, while drying the bacterial dispersion at the same time.

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Section: Introductionmentioning

confidence: 99%

Effects of Electrospinning on the Viability of Ten Species of Lactic Acid Bacteria in Poly(Ethylene Oxide) Nanofibers

et al. 2019

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“…Ciprofloxacin hydrochloride-loaded electrospun polycarbonate urethane nanofiber prepared for wound dressing showed prolonged drug release [139]. Eudragit L100-55 nano-fibers incorporated with diclofenac sodium (DS) exhibited a pH-dependent drug generation pattern when used for the constant release of the anti-inflammatory agent and presented a great possibility to be employed as oral colon-targeted drug release systems [140]. In addition to drugs, vitamins have been encapsulated within electro-spun nano-fibers as transdermal delivery carriers with increased agent activity, and drug delivery systems for cancer treatment showed improved tumor suppression [141].…”

Section: Drug Delivery Systems Prepared By Electro-spinningmentioning

confidence: 99%

Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review

et al. 2020

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Pharmaceutical nano-fibers have attracted widespread attention from researchers for reasons such as adaptability of the electro-spinning process and ease of production. As a flexible method for fabricating nano-fibers, electro-spinning is extensively used. An electro-spinning unit is composed of a pump or syringe, a high voltage current supplier, a metal plate collector and a spinneret. Optimization of the attained nano-fibers is undertaken through manipulation of the variables of the process and formulation, including concentration, viscosity, molecular mass, and physical phenomenon, as well as the environmental parameters including temperature and humidity. The nano-fibers achieved by electro-spinning can be utilized for drug loading. The mixing of two or more medicines can be performed via electro-spinning. Facilitation or inhibition of the burst release of a drug can be achieved by the use of the electro-spinning approach. This potential is anticipated to facilitate progression in applications of drug release modification and tissue engineering (TE). The present review aims to focus on electro-spinning, optimization parameters, pharmacological applications, biological characteristics, and in vivo analyses of the electro-spun nano-fibers. Furthermore, current developments and upcoming investigation directions are outlined for the advancement of electro-spun nano-fibers for TE. Moreover, the possible applications, complications and future developments of these nano-fibers are summarized in detail.

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“…Although solution parameters include polymer concentration, viscosity, and conductivity, temperature and relative humidity are two factors that been classified as environmental parameters. Detailed discussion on the effects of these parameters in conventional coaxial electrospinning is not provided, as it has been comprehensively reviewed elsewhere [19,20,105]. The focus discussion of this section is shifted to advanced and complex coaxial electrospinning instead, with thorough discussion is presented in the next paragraphs.…”

Section: Coaxial Electrospinningmentioning

confidence: 99%

Core–Shell Fibers: Design, Roles, and Controllable Release Strategies in Tissue Engineering and Drug Delivery

et al. 2019

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The key attributes of core–shell fibers are their ability to preserve bioactivity of incorporated-sensitive biomolecules (such as drug, protein, and growth factor) and subsequently control biomolecule release to the targeted microenvironments to achieve therapeutic effects. Such qualities are highly favorable for tissue engineering and drug delivery, and these features are not able to be offered by monolithic fibers. In this review, we begin with an overview on design requirement of core–shell fibers, followed by the summary of recent preparation methods of core–shell fibers, with focus on electrospinning-based techniques and other newly discovered fabrication approaches. We then highlight the importance and roles of core–shell fibers in tissue engineering and drug delivery, accompanied by thorough discussion on controllable release strategies of the incorporated bioactive molecules from the fibers. Ultimately, we touch on core–shell fibers-related challenges and offer perspectives on their future direction towards clinical applications.

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Core-shell nanofibers as drug delivery systems

Cited by 57 publications

References 116 publications

Effects of Electrospinning on the Viability of Ten Species of Lactic Acid Bacteria in Poly(Ethylene Oxide) Nanofibers

Effects of Electrospinning on the Viability of Ten Species of Lactic Acid Bacteria in Poly(Ethylene Oxide) Nanofibers

Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review

Core–Shell Fibers: Design, Roles, and Controllable Release Strategies in Tissue Engineering and Drug Delivery

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