Core–shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery

Tong, Chen; Zhao, Tong; Wei, Dongfeng; Wei, Yanxia; Li, Yuanyuan; Zhang, Haixia

doi:10.1016/j.carbpol.2012.10.022

Cited by 65 publications

(25 citation statements)

References 37 publications

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“…in the form of Au-ZnO nanocomposites, dispersed in the same medium as for the cell lines. It is important to note that ZnO itself has limited anticancer properties [52][53][54][55] and in addition it is nontoxic; in other words it does not affect normal cells, as elegantly pointed out in the work of Akhtar et al 52 We have already established the nature of the nanoparticles/ clusters, i.e. n% Au-ZnO where n varies from 0.0 to 5% of input gold.…”

Section: View Article Onlinementioning

confidence: 93%

Fuel mediated solution combustion synthesis of ZnO supported gold clusters and nanoparticles and their catalytic activity and in vitro cytotoxicity

Chanu

Thangavelu

Manoharan

2014

Phys. Chem. Chem. Phys.

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Nanocomposites of gold nanoparticles and semiconductor ZnO with wurtzite structure, made by solution combustion synthesis (SCS), as a function of the Zn/fuel ratio with polyethylene glycol (PEG) as fuel exhibit the presence of both nanoparticles and clusters. Atomic gold clusters present on the surface of ZnO nanorods which can be identified by XPS and SEM are easily monitored and characterized by positive ion MALDI experiments as mostly odd numbered clusters, Au3 to Au11 in decreasing amounts. Low concentrations of the fuel produce AuClO and nanoparticles (NPs), with no clusters. Au-ZnO nanocomposites at all [Au] exhibit single blue shifted plasmon absorption and corresponding photoluminescence (PL). Increasing particle size prefers surface plasmon resonance (SPR) scattering of metal that could lead to PL enhancement; however, available ZnO surface in the Au-ZnO composite becomes more important than the particle size of the composite with higher [Au]. The catalytic activity of these Au-ZnO nanocomposites tested on 4-nitrophenol clearly revealed the presence of an intermediate with both NPs and clusters playing different roles. An in vitro study of cytotoxicity on MCF-7 cell lines revealed that these gold nanostructures have turned out to be powerful nanoagents for destruction of cancer cells even with small amounts of gold particles/clusters. The nanorods of ZnO, known to be nontoxic to normal cells, play a lesser role in the anticancer activity of these Au-ZnO nanocomposites.

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Section: View Article Onlinementioning

confidence: 93%

Fuel mediated solution combustion synthesis of ZnO supported gold clusters and nanoparticles and their catalytic activity and in vitro cytotoxicity

Chanu

Thangavelu

Manoharan

2014

Phys. Chem. Chem. Phys.

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“…Among nanoparticles, NPs of ZnO have effective catalytic efficiency, chemical stability and strong adsorption ability and therefore are gaining more attention from researchers [10][11][12][13]. The antimicrobial potential of ZnO NPs has already been proved and utilized against a variety of bacterial and fungal strains [10][11][12][13][14]. The United States' Food and Drug Administration (US-FDA) has approved ZnO as a safe material having extensive applications in drug delivery, pharmaceuticals and food supplements etc.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of the ZnO NP–Ampicillin/Sulbactam Nanoantibiotic: Optimization of Formulation Variables Using RSM Coupled GA Method and Antibacterial Activities

et al. 2019

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Nanoparticles (NPs) possessing antibacterial activity represent an effective way of overcoming bacterial resistance. In the present work, we report a novel formulation of a nanoantibiotic formed using Ampicillin/sulbactam (Ams) and a zinc oxide nanoparticle (ZnO NP). 'ZnO NP-Ams' nanoantibiotic formulation is optimized using response surface methodology coupled genetic algorithm approach. The optimized formulation of nanoantibiotic (ZnO NP: 49.9 µg/mL; Ams: 33.6 µg/mL; incubation time: 27 h) demonstrated 15% enhanced activity compared to the unoptimized formulation against K. pneumoniae. The reactive oxygen species (ROS) generation was directly proportional to the interaction time of nanoantibiotic and K. pneumoniae after the initial lag phase of 18 h as evident from 2s'-7'-Dichlorodihydrofluorescein diacetate assay. A low minimum inhibitory concentration (6.25 µg/mL) of nanoantibiotic formulation reveals that even a low concentration of nanoantibiotic can prove to be effective against K. pneumoniae. The importance of nanoantibiotic formulation is also evident by the fact that the 100 µg/mL of Ams and 25 µg of ZnO NP was required individually to inhibit the growth of K. pneumonia, whereas only 6.25 µg/mL of optimized nanoantibiotic formulation (ZnO NP and Ams in the ratio of 49.9: 33.6 in µg/mL and conjugation time of 27 h) was needed for the same.

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“…Park and co-workers20 developed gold nanoparticles functionalized with near-infrared fluorescence dye-labeled HA and investigated their anticancer abilities in vitro and in vivo , demonstrating that the gold nanoparticles modified with HA could effectively identify metastatic tumors as well as diagnose and treat HA degrading diseases. However, it is noteworthy that, in the majority of studies, drug delivery systems have been utilized with only a single anticancer drug212223. Therefore, considerable effort should be directed toward devising and developing novel platforms for the loading and delivery of a variety of anticancer drugs.…”

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confidence: 99%

Polysaccharide-Gold Nanocluster Supramolecular Conjugates as a Versatile Platform for the Targeted Delivery of Anticancer Drugs

Chen

Zhang

et al. 2014

Sci Rep

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Through the high affinity of the β-cyclodextrin (β-CD) cavity for adamantane moieties, novel polysaccharide-gold nanocluster supramolecular conjugates (HACD-AuNPs) were successfully constructed from gold nanoparticles (AuNPs) bearing adamantane moieties and cyclodextrin-grafted hyaluronic acid (HACD). Due to their porous structure, the supramolecular conjugates could serve as a versatile and biocompatible platform for the loading and delivery of various anticancer drugs, such as doxorubicin hydrochloride (DOX), paclitaxel (PTX), camptothecin (CPT), irinotecan hydrochloride (CPT-11), and topotecan hydrochloride (TPT), by taking advantage of the controlled association/dissociation of drug molecules from the cavities formed by the HACD skeletons and AuNPs cores as well as by harnessing the efficient targeting of cancer cells by hyaluronic acid. Significantly, the release of anticancer drugs from the drug@HACD-AuNPs system was pH-responsive, with more efficient release occurring under a mildly acidic environment, such as that in a cancer cell. Taking the anticancer drug DOX as an example, cell viability experiments revealed that the DOX@HACD-AuNPs system exhibited similar tumor cell inhibition abilities but lower toxicity than free DOX due to the hyaluronic acid reporter-mediated endocytosis. Therefore, the HACD-AuNPs supramolecular conjugates may possess great potential for the targeted delivery of anticancer drugs.

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Core–shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery

Cited by 65 publications

References 37 publications

Fuel mediated solution combustion synthesis of ZnO supported gold clusters and nanoparticles and their catalytic activity and in vitro cytotoxicity

Fuel mediated solution combustion synthesis of ZnO supported gold clusters and nanoparticles and their catalytic activity and in vitro cytotoxicity

Preparation and Evaluation of the ZnO NP–Ampicillin/Sulbactam Nanoantibiotic: Optimization of Formulation Variables Using RSM Coupled GA Method and Antibacterial Activities

Polysaccharide-Gold Nanocluster Supramolecular Conjugates as a Versatile Platform for the Targeted Delivery of Anticancer Drugs

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