Core‐Shell Nanocapsules Stabilized by Single‐Component Polymer and Nanoparticles for Magneto‐Chemotherapy/Hyperthermia with Multiple Drugs

Abstract

Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.

Controlled drug release from pharmaceutical nanocarriers

“…For example, hydrophilic compounds like nucleic acids and hydrophobic drugs such as PTX are difficult to deliver simultaneously in one type of carrier but rather require amphiphilic carriers. For instance, co-encapsulation of hydrophilic DOX and hydrophobic PTX was achieved in nanocapsules composed of a hydrophilic drug reservoir and a hydrophobic shell made of PVA and iron oxide (Hu et al, 2012). In the absence of external stimuli, DOX loaded in the hydrophilic core showed zero-order release kinetics with minimal initial burst release, whereas PTX in the shell showed initial burst release, both releasing <10% of the total drug in 4h.…”

“…In the absence of external stimuli, DOX loaded in the hydrophilic core showed zero-order release kinetics with minimal initial burst release, whereas PTX in the shell showed initial burst release, both releasing <10% of the total drug in 4h. The drug release was substantially enhanced (to 45–75% depending on the MW of PVA in 10h) with the application of magnetic field, which created local heating and polymer chain relaxation in the shell (Hu et al, 2012). Amphiphilic cationic micelles, made of PEI-grafted PCL, were developed for the co-delivery of DNA (luciferase reporter gene, pCMV-Luc) and anti-cancer drug DOX (Qiu and Bae, 2007).…”

Intravenous magnetic nanoparticle cancer hyperthermia

“…23 Hydrophobic and hydrophilic drugs have also been encapsulated, via emulsification, with MNPs in a polyvinyl alcohol polymer that demonstrated drug release when heated with an AMF and mouse tumor control over 30 days. 24 Oleic acid/Pluronic ® -coated MNPs were associatively loaded with daunorubicin and 5-bromotetrandrine and effectively treated tumors for 12 days after AMF heating -these were shown to decrease P-glycoprotein and Bcl-2 expression while increasing Bax and caspase-3 expression. which may assist in combating multidrug resistance.…”

Luminomagnetic Silica-Coated Heterodimers of Core/Shell FePt/Fe3O4 and CdSe Quantum Dots as Potential Biomedical Sensor

“…Among the different types of luminomagnetic nanomaterials, the heteronanostructures (HNS) show convenient response in biomedical applications, because its features provide properties related to two or more individual nanostructures in the unique nanomaterial [4][5][6]. Some applications of this theranostic platform include magnetic resonance imaging (MRI) [7], confocal and fluorescence imaging microscopies [4,8] acting as contrast agents, cell separation and drug delivery [9,10] as carriers, in both optic-and magnetohyperthermia [11,12], in which the nanoparticles are the source of heat transfer, and photodynamic therapy by singlet oxygen generation [13]. Among various kinds of theranostic nanomaterials, those based on magnetic nanoparticles can achieve both diagnosis and therapy of cancer due to their magnetic property [14].…”