Core-shell magnetoelectric nanorobot – A remotely controlled probe for targeted cell manipulation

Background: Magnetic Particle Imaging (MPI) is an emerging imaging modality for quantitative direct imaging of superparamagnetic iron oxide nanoparticles (SPION or SPIO). With different physics from MRI, MPI benefits from ideal image contrast with zero background tissue signal. This enables clear visualization of cancer with image characteristics similar to PET or SPECT, but using radiation-free magnetic nanoparticles instead, with infinite-duration reporter persistence in vivo. MPI for cancer imaging: demonstrated months of quantitative imaging of the cancer-related immune response with in situ SPION-labelling of immune cells (e.g., neutrophils, CAR T-cells). Because MPI suffers absolutely no susceptibility artifacts in the lung, immuno-MPI could soon provide completely noninvasive early-stage diagnosis and treatment monitoring of lung cancers. MPI for magnetic steering: MPI gradients are ~150 × stronger than MRI, enabling remote magnetic steering of magneto-aerosol, nanoparticles, and catheter tips, enhancing therapeutic delivery by magnetic means. MPI for precision therapy: gradients enable focusing of magnetic hyperthermia and magnetic-actuated drug release with up to 2 mm precision. The extent of drug release from the magnetic nanocarrier can be quantitatively monitored by MPI of SPION’s MPS spectral changes within the nanocarrier. Conclusion: MPI is a promising new magnetic modality spanning cancer imaging to guided-therapy.

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“…This can directly kill the cancer cells or increase their susceptibility to chemotherapeutics. [ 144 ].…”

Section: Magnetic Methods For Cancer Therapy In Context Of Magnetic Particle Imagingmentioning

confidence: 99%

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay

Chandrasekharan

Fellows

et al. 2021

Cancers

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“…These materials have been shown to be effective in different applications such as drug delivery, tissue engineering and targeted cell manipulation [228][229][230][231][232][233][234][235][236].…”

Section: Emerging Piezoelectric Materials and Strategiesmentioning

confidence: 99%

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

2018

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Electrical stimulation/electrical microenvironment are known effect the process of bone regeneration by altering the cellular response and are crucial in maintaining tissue functionality. Piezoelectric materials, owing to their capability of generating charges/potentials in response to mechanical deformations, have displayed great potential for fabricating smart stimulatory scaffolds for bone tissue engineering. The growing interest of the scientific community and compelling results of the published research articles has been the motivation of this review article. This article summarizes the significant progress in the field with a focus on the fabrication aspects of piezoelectric materials. The review of both material and cellular aspects on this topic ensures that this paper appeals to both material scientists and tissue engineers.

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“…Large magnetoelectric (ME) coefficients have been achieved in bulk multiferroic composites . Recent advances in thin‐film synthesis have enabled the fabrication of multiferroic thin films and nanocomposites for applications in microelectronic devices . Vertically aligned nanocomposite (VAN) thin films, consisting of two phases epitaxially grown on a substrate, have demonstrated a unique approach for controlling vertical interfacial area and vertical lattice strain .…”

mentioning

confidence: 99%

Competing Interface and Bulk Effect–Driven Magnetoelectric Coupling in Vertically Aligned Nanocomposites

et al. 2019

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Room‐temperature magnetoelectric (ME) coupling is developed in artificial multilayers and nanocomposites composed of magnetostrictive and electrostrictive materials. While the coupling mechanisms and strengths in multilayers are widely studied, they are largely unexplored in vertically aligned nanocomposites (VANs), even though theory has predicted that VANs exhibit much larger ME coupling coefficients than multilayer structures. Here, strong transverse and longitudinal ME coupling in epitaxial BaTiO3:CoFe2O4 VANs measured by both optical second harmonic generation and piezoresponse force microscopy under magnetic fields is reported. Phase field simulations have shown that the ME coupling strength strongly depends on the vertical interfacial area which is ultimately controlled by pillar size. The ME coupling in VANs is determined by the competition between the vertical interface coupling effect and the bulk volume conservation effect. The revealed mechanisms shed light on the physical insights of vertical interface coupling in VANs in general, which can be applied to a variety of nanocomposites with different functionalities beyond the studied ME coupling effect.

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Core-shell magnetoelectric nanorobot – A remotely controlled probe for targeted cell manipulation

Cited by 49 publications

References 31 publications

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

Competing Interface and Bulk Effect–Driven Magnetoelectric Coupling in Vertically Aligned Nanocomposites

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