Core-shell insulin-loaded nanofibrous scaffolds for repairing diabetic wounds

Lee, Chen‐Hung; Hung, Kuo‐Chun; Hsieh, Ming‐Jer; Chang, Shang‐Hung; Juang, Jyuhn‐Huarng; Wen, Ming‐Shien; Liu, Shih‐Jung

doi:10.1016/j.nano.2019.102123

Cited by 62 publications

(36 citation statements)

References 40 publications

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“…32 Lee et al (2019) reported core-shell insulin-loaded nanofibrous scaffolds accelerated diabetic wound repair through promoting epithelialization. 33 Additionally, Li et al (2019) reported human hair keratin-conjugated insulin promoted wound healing in rats with full-thickness wound by stimulating cellular migration. 34 Taken together, these studies indicate that insulin-loaded dressings can improve wound healing in a sustained release manner.…”

Section: Animal Studiesmentioning

confidence: 99%

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Wang

2020

DMSO

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Wound healing is a complex biological process that repairs damaged tissues and restores skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies. Although many studies have addressed the healing effect of systemic insulin on burn wound, only few have investigated the efficacy of topical insulin. Thus, this study aimed to review evidence of the effects of topical insulin on wound healing, including on diabetic and non-diabetic wounds. The presented animal and clinical studies support that topical insulin improves wound healing through several mechanisms without causing side effects. Additionally, various wound dressings accelerate the wound healing with controlled and sustained delivery of bioactive insulin. Therefore, topical insulin has been appreciated in field of wound healing, and further studies are needed to improve our understanding of the role of insulin in the healing of various wounds.

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Section: Animal Studiesmentioning

confidence: 99%

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Wang

2020

DMSO

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“…Lee et al developed core-shell nanofibrous bioactive insulin-loaded PLGA scaffolds through coaxial electrospinning for sustained release of the synthetic hormone in diabetic rats. The scaffolds exhibited a release of the molecule during four weeks, which promoted diabetic wound healing [236].…”

Section: Drug Delivery Applications Of Bioengineered Thermo-responsive Scaffolds In Wound Healingmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

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Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

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“…59 In addition, electrospun PLGA materials have also been applied in the field of drug delivery systems (DDS) to maintain the dose of the drug within therapeutic ranges over an extended period of time. 60,61 The loading of diabetes drugs, 62 antibiotics 58 and bone morphogenetic proteins 63 have been reported. Poly lactide-co-glycolic microspheres (PLGA-MS) was also used in DDS 64 to protect peptides (AMPs) or microbes (such as lysozyme) from rapid degradation.…”

Section: Pclmentioning

confidence: 99%

“…In addition, considering the close relationship between diabetes and periodontal disease, diabetes drugs such as vildagliptin 148 or insulin 62 loaded membranes might be effective in periodontal defects. Similarly, metformin was loaded on electrospun nanofibrous recently and fabricated functional GBR membranes successfully.…”

Section: Other Drugsmentioning

confidence: 99%

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

Ren

et al. 2020

J Biomater Appl

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Considering the specificity of periodontium and the unique advantages of electrospinning, this technology has been used to fabricate biodegradable tissue engineering materials for functional periodontal regeneration. For better biomedical quality, a continuous technological progress of electrospinning has been performed. Based on property of materials (natural, synthetic or composites) and additive novel methods (drug loading, surface modification, structure adjustment or 3 D technique), various novel membranes and scaffolds that could not only relief inflammation but also influence the biological behaviors of cells have been fabricated to achieve more effective periodontal regeneration. This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.

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Core-shell insulin-loaded nanofibrous scaffolds for repairing diabetic wounds

Cited by 62 publications

References 40 publications

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

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